Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT07491445RecruitingPhase 3
Daraxonrasib plus chemo for first-line metastatic pancreatic cancer
This trial tests a new targeted therapy (daraxonrasib) combined with standard chemotherapy as the first treatment for people whose pancreatic cancer has spread. The goal is to see if this combination can help shrink or control the cancer better than chemotherapy alone.
Scottsdale, ArizonaAges 18 years+ - NCT07630961RecruitingPhase 1
New PET Imaging Scans for Advanced Solid Tumors
This trial tests two new radioactive imaging scans (called PET scans) designed to better detect certain advanced cancers like pancreatic, lung, breast, colon, or soft-tissue tumors. The goal is to see if these scans help doctors find and track cancer more accurately than standard imaging.
Odense CAges 18 years+ - NCT02127398RecruitingPhase 2
Fecal transplants for hard-to-treat C. difficile infection
This Phase 2 study tests whether placing stool from a healthy donor into your gut can treat repeated, hard-to-control C. difficile colitis. It may help restore healthy gut bacteria and reduce future flare-ups.
Durham, North CarolinaAges 18 years+ - NCT07607769Recruiting
Tremelimumab and Durvalumab for Untreated Advanced Liver Cancer
This Italian study follows patients with advanced liver cancer (hepatocellular carcinoma) who receive a combination immunotherapy treatment called STRIDE for the first time. The trial tracks how well the treatment works, how it affects quality of life, and its safety in people with moderate to severe liver disease.
AnconaAges 18–100 - NCT07427927Enrolling by invitation
Hemorrhoid surgery patient groups study
This study looks at people who have had surgery for hemorrhoids to find common patterns or groups among them. It may help improve care by better understanding different types of hemorrhoid disease.
San Donato Milanese, MilanAges 18 years+ - NCT07501078RecruitingPhase 2
Aquamin supplement for preventing pouch inflammation after J-pouch surgery
This study tests whether a natural supplement called Aquamin (a red algae-derived mineral source) can help prevent inflammation in people who have had surgery for ulcerative colitis and now have a J-pouch. It aims to see if this supplement reduces pouch inflammation and related symptoms.
Ann Arbor, MichiganAges 18–80 - NCT06187961RecruitingPhase 2
Combination therapy for liver cancer that cannot be removed with surgery
This study tests a combination of three treatments (HAIC, lenvatinib, and cadonilimab) as a way to shrink liver tumors that cannot be removed with surgery. The goal is to make the tumors smaller so they might be removed later, and to see how safe and effective this combination is.
Wuhan, HubeiAges 18 years+ - NCT07788729Recruiting
Support program for cancer patients and their caregivers
This study tests a program that provides social support and short learning sessions to help cancer patients and their caregivers manage daily life. It aims to improve well-being and care for both patients and their support persons.
Augsburg, BavariaAges 18 years+ - NCT07786766RecruitingPhase 2
Pemigatinib plus immunotherapy for FGFR2-positive bile duct cancer
This study tests a combination of two drugs—pemigatinib (a targeted therapy) and a PD-1 inhibitor (an immunotherapy)—with or without chemotherapy, for people with advanced bile duct cancer that has an FGFR2 fusion or rearrangement. The goal is to see if this combination is more effective than standard treatment, and to find better ways to treat this type of cancer.
BeijingAges 18–80 - NCT07787052Recruiting
Studying gastric cancer after chemotherapy and surgery
This trial collects and studies tumor and lymph node samples from people with gastric cancer who have had chemotherapy and surgery. The goal is to understand how cancer responds to treatment and to improve future care.
LyonAges 18 years+ - NCT07786831Recruiting
Dietary study for liver health in young adults
This study tests a 12-week dietary program to see if it can improve liver health in young adults. Participants will be randomly assigned to a specific diet and will attend three check-ups to measure their liver and body changes.
Vienna, AustriaAges 20–30 - NCT06811116RecruitingPhase 1/Phase 2
Sapanisertib plus cabozantinib for advanced liver cancer
This trial studies a combination of two drugs for advanced liver cancer with a specific gene change. The goal is to see if adding sapanisertib to the usual cabozantinib treatment helps people live longer without their cancer growing.
Irvine, CaliforniaAges 18 years+ - NCT07788079Recruiting
Ostomy care education using the teach-back method
This study tests if a special way of teaching ostomy care, called the teach-back method, helps people with an ostomy feel more confident and less anxious about managing it. Participants will learn how to care for their ostomy and answer questions about their self-care and feelings.
Istanbul, ÜsküdarAges 18–84 - NCT07787312Recruiting
Ultrasound for swallowing and muscle loss in intensive care patients
This study uses ultrasound to check the muscles that help you swallow and move. It aims to see if measuring these muscles can predict swallowing problems and muscle loss after being on a breathing machine.
Madrid, MadridAges 18 years+ - NCT04239573Recruiting
Compare pancreatic cyst checkup programs and test markers
This study compares different ways to monitor pancreatic cysts and also measures blood or other test markers to see which approach is more helpful. It may help patients by finding the safest, most effective way to track certain cysts that could otherwise be hard to manage.
Birmingham, AlabamaAges 50–75 - NCT07654283RecruitingPhase 2
Study of AHB-137 for chronic hepatitis B
This trial tests a new drug, AHB-137, in people with chronic hepatitis B who are already on a stable antiviral treatment. It aims to see if AHB-137 can help lower the virus further or improve outcomes.
Palo Alto, CaliforniaAges 18–65 - NCT03853772Enrolling by invitation
Heartburn registry for long-term symptom and care follow-up
This registry enrolls people with GERD (chronic heartburn/reflux) to track symptoms and treatments over time for up to 5 years. It may help researchers understand what works best in everyday care, and you’ll be asked to complete check-in surveys.
Orange, CaliforniaAges 18 years+ - NCT07660848RecruitingPhase 2
A study of two new injections for fatty liver disease with MASH
This trial tests two new injections (HRS-4729 and HRS-9531) for people with MASH, a type of fatty liver disease. The study aims to see if these drugs can help reduce liver fat and improve liver health.
Beijing, Beijing MunicipalityAges 18–75 - NCT07709897RecruitingPhase 2
Preventing nausea & vomiting after surgery
This trial tests if adding HRS5580 to standard anti-nausea medicine works better to stop vomiting after surgery. You may qualify if you are at moderate-to-high risk for nausea after general anesthesia.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07700667RecruitingPhase 2
Testing a new drug combo for advanced esophageal cancer
This trial tests a new drug combination (SKB500 plus other treatments) for people with advanced esophageal squamous cell carcinoma. It aims to see if the combination is safe and effective for those who have had little or no prior treatment.
ChangchunAges 18–75 - NCT07378930Recruiting
ULTRA-SAFE: More frequent monitoring after advanced polyps
This trial compares a new, more frequent surveillance schedule (yearly stool tests and colonoscopies every 2 years) to the standard schedule for people who have had advanced polyps removed. It aims to see if the extra testing helps prevent future colon cancer.
Taipei, TaipeiAges 40–75 - NCT06885697RecruitingPhase 1
CAR T cells targeting mesothelin for solid tumors
This study tests a new treatment called CAR T cells that target a protein called mesothelin found on certain cancer cells. The CAR T cells are made from your own immune cells and may help shrink tumors that have not responded to other therapies.
Bethesda, MarylandAges 18–120 - NCT06995898Recruiting
Blood test study for early cancer detection
This study is testing a new blood test that may help find cancer early. You will give blood samples over a year, and researchers will check them for signs of cancer.
Pleasanton, CaliforniaAges 45–75 - NCT07786389Enrolling by invitationPhase 1/Phase 2
Seaweed supplement for ulcerative colitis inflammation
This study tests whether a supplement made from seaweed (fucoidan) can help reduce gut inflammation in people with mild to moderate ulcerative colitis. If you join, you'll take the supplement and have your symptoms and blood levels checked.
Lahore, Punjab ProvinceAges 18–64
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.