Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT03731442RecruitingPhase 3
Radiation plus chemotherapy for esophageal cancer that came back
This Phase 3 trial studies giving combined chemotherapy and radiation to treat esophageal cancer that has returned after earlier surgery and/or prior treatments. It may help control the cancer in the area where it comes back, especially when the surgical margins were not fully clear or the cancer is outside the original radiation field.
Beijing, Beijing MunicipalityAges 16–70 - NCT03792854Recruiting
Quality-of-life study after standard treatment for anal cancer
This observational study follows people with anal cancer to understand how their quality of life changes after they receive standard chemoradiation therapy. It may help doctors better support patients with symptoms, recovery, and daily functioning over time.
Munich, BavariaAges 18 years+ - NCT03498326RecruitingPhase 2
Gemcitabine plus celecoxib after pancreatic surgery
This trial tests whether adding celecoxib to gemcitabine chemotherapy after complete (R0) pancreatic tumor removal can lower the chance the cancer comes back. It may help people who have had successful surgery but still need anti-cancer treatment.
Hangzhou, ZhejiangAges 18–90 - NCT03064646Recruiting
Preserving tissue in near-complete rectal cancer response
This trial studies whether it’s safe to preserve the rectum (instead of removing it right away) for people with locally advanced rectal cancer who respond very well after pre-treatment radiation and/or chemotherapy. It may help some patients avoid major surgery, but eligibility depends on response seen on exam, scope, and MRI, and on having no spread to distant organs.
Elche, AlicanteAges 18 years+ - NCT03686709Recruiting
Extra scan and blood testing with Y90 radioembolization
This study looks at how well Y90 “radioembolization” treatment delivers radiation and how much radiation reaches your body. If you can safely get extra PET/CT scans and blood tests around your treatment, you may be invited to participate.
Knoxville, TennesseeAges 18 years+ - NCT03686137Recruiting
Liver surgery database study for liver tumors
This study collects information from people having liver surgery for a non-cancerous tumor or for liver cancer (primary or cancer that spread to the liver). It doesn’t usually add treatment—your care is documented to help doctors learn and improve future decisions.
Marseille, Bouches Du RhoneAges 18 years+ - NCT03731130Recruiting
Study on quality of life after rectal cancer treatment and surgery
This observational study follows people with rectal cancer who get radiation (with or without chemotherapy) before surgery. It aims to understand how these treatments affect quality of life after surgery.
Munich, BavariaAges 18 years+ - NCT03770936RecruitingPhase 3
Drugs to reduce liver scarring in chronic hepatitis C
This Phase 3 study tests medicines to see whether they can reduce liver scarring (fibrosis) in people with long-term hepatitis C. If you qualify, you may receive the study treatment and be monitored over time to see how your liver is affected.
TantaAges 20 years+ - NCT03804931RecruitingPhase 2/Phase 3
Stool transplant for moderate to severe ulcerative colitis
This trial tests whether transplanting stool bacteria into the colon (fecal microbiota transplantation) can improve ulcerative colitis symptoms in people with active, moderate to severe disease. If you qualify, the study team will also check that it’s safe for you and that you can safely undergo a scope exam.
Guangzhou, GuangdongAges 18–65 - NCT03807687Recruiting
Registry for people with pancreatic diseases
This is a registry that collects information from people who have a pancreatic disease. It may help doctors better understand different pancreatic conditions and improve future care.
VeronaAges 18 years+ - NCT03671252RecruitingPhase 3
Chemotherapy before surgery for rectal cancer vs chemo with radiation
This Phase 3 trial compares two treatment plans given before rectal surgery. It tests whether stronger chemotherapy alone works better than chemotherapy pills plus long-term radiation to improve outcomes for locally advanced rectal cancer.
Guangzhou, GuangdongAges 18–75 - NCT03385018Recruiting
Laparoscopic total stomach surgery trial for stomach cancer
This trial studies whether a minimally invasive (laparoscopic) removal of the entire stomach, along with lymph node removal, can be done safely and effectively for certain stomach cancers. It may be an option if your cancer is in the stomach, has limited spread to nearby lymph nodes, and can be fully removed.
SeoulAges 20–80 - NCT03919461RecruitingPhase 2
Preventing colon and rectal cancer spread after surgery
This Phase 2 study tests medicines given around the time of colon or rectal cancer surgery to help lower the chance the cancer will later spread to other parts of the body. If you are planned for curative (potentially curable) surgery and have no signs of spread yet, the trial may help prevent future metastases.
AfulaAges 20–80 - NCT03267069Recruiting
Study of alcohol use in alcoholic liver disease
This study looks at alcohol use behaviors in people who have alcoholic liver disease. It may help researchers better understand patterns of alcohol use and how to support safer health decisions.
New York, New YorkAges 18–80 - NCT02037867Recruiting
Study your liver blood markers if you’re at risk
This study looks at how certain blood tests (liver biomarkers) change in people with higher risk for liver disease. It may help doctors understand who is developing liver problems earlier and what patterns in blood tests matter most.
Nottingham, NottsAges 18 years+ - NCT02471443Recruiting
Laparoscopic surgery for severe endometriosis involving bowel
This trial studies how well a minimally invasive (laparoscopic) surgery works for people with severe endometriosis that affects the bowel. It may help improve symptoms and quality of life, and it focuses on planned surgery for this specific type of endometriosis.
Guildford, SurreyAges Any age - NCT02332785Recruiting
Study for people with serrated colon polyps
This study follows people who have serrated polyps in the colon to learn more about these growths. It may help doctors better understand what they are and how to manage them.
Houston, TexasAges Any age - NCT03925662RecruitingPhase 3
Mebendazole added to stage 4 colon cancer care
This trial studies whether adding mebendazole (an existing anti-parasite medicine) to standard treatment can improve outcomes for people with stage 4 colon cancer. You might qualify if you have stage 4 colorectal cancer and none of the key safety concerns.
CairoAges 18 years+ - NCT03925701RecruitingPhase 3
Vildagliptin, with or without metformin, for fatty liver and diabetes
This trial studies how vildagliptin compares to vildagliptin plus metformin in people who have fatty liver disease along with type 2 diabetes. It may help find the safest and most effective way to improve liver health and diabetes control.
TantaAges 18 years+ - NCT03913962Recruiting
Exercise study for children with chronic or autoimmune conditions
This study looks at how physical activity affects muscle, metabolism (how your body uses energy), and body composition in children with certain chronic or autoimmune conditions. It may help doctors understand what types of exercise and monitoring are most beneficial and safe.
Clermont-FerrandAges 6–18 - NCT03961373RecruitingPhase 3
Standard vs longer lymph node surgery after chemo for stomach cancer
This study compares two surgical approaches to remove lymph nodes after you’ve already had chemotherapy for stomach cancer. It aims to see whether removing lymph nodes in a more extended way improves outcomes without causing unacceptable side effects.
SienaAges 18–80 - NCT03941561RecruitingPhase 3
Shorter versus longer chemotherapy for stage II stomach cancer
This trial compares two lengths of an oral chemotherapy medicine (9 months vs 1 year) after surgery for stage II stomach cancer. It aims to see which schedule works better and is easier to complete, while checking safety for people without major health problems.
AnqingAges 18–75 - NCT02423395RecruitingPhase 3
Orphenadrine for muscle cramps in people with cirrhosis
This trial tests whether orphenadrine (a medication used to reduce muscle cramping) can lessen muscle cramps in people who have cirrhosis of the liver. It may help if your cramps happen often, but you must avoid certain medication conflicts and health situations.
TantaAges Any age - NCT04074538Recruiting
Colorectal cancer study to help researchers learn patterns
This study is collecting information from people with newly diagnosed colon or rectal cancer, to better understand the disease and support future research. It may help you and others by improving how colorectal cancer is studied and potentially treated over time.
Hangzhou, ZhejiangAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.