Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT06943755RecruitingPhase 2/Phase 3
Zanzalintinib vs Everolimus for Neuroendocrine Tumors
This trial compares a new targeted therapy (zanzalintinib) with an existing drug (everolimus) for people with advanced neuroendocrine tumors (NETs). It aims to see which treatment works better and may offer a new option for patients whose cancer has grown despite previous treatments.
Birmingham, AlabamaAges 18 years+ - NCT07775287RecruitingPhase 3
Petosemtamab plus chemotherapy for advanced colorectal cancer
This study tests a new drug called petosemtamab combined with chemotherapy for people with advanced colorectal cancer that has not responded to one prior treatment. The trial aims to see if adding petosemtamab helps the cancer shrink or grow more slowly compared to adding a standard targeted therapy like cetuximab or bevacizumab.
ManatiAges 18 years+ - NCT07179575RecruitingPhase 1/Phase 2
Study of LW231 for people with chronic hepatitis B
This trial tests a new drug, LW231, in people with chronic hepatitis B. It aims to see if the drug can reduce the amount of virus and surface antigen in your blood, and if it is safe for you.
Hangzhou, ZhejiangAges 18–60 - NCT06893276Recruiting
Wellness program for pancreatic cancer
This study tests an online wellness program that helps people with pancreatic cancer manage stress and symptoms. The program is available in English and Spanish and is designed to improve your quality of life during treatment.
Miami, FloridaAges 18 years+ - NCT04157127RecruitingPhase 1
Pancreatic cancer vaccine with chemotherapy before/around surgery
This early-stage trial tests a personalized immune “vaccine” made from dendritic cells, given alongside standard chemotherapy for pancreatic cancer that may be removable by surgery (resectable or borderline resectable). If it works, it may help your immune system better recognize and attack the cancer around the time of treatment.
Houston, TexasAges 18 years+ - NCT05496491Recruiting
Before-surgery radiation and chemo for rectal cancer
This study tests a specific “before surgery” treatment (radiation plus chemotherapy), followed by more chemotherapy to improve outcomes in people with certain types of rectal cancer. You might be considered if your cancer is locally advanced but not spread to distant organs.
LarissaAges 18–80 - NCT06984484Recruiting
Afluxin for GERD: safety and performance study
This trial tests a new treatment called Afluxin for people with gastroesophageal reflux disease (GERD), which causes heartburn and regurgitation. It aims to see if Afluxin is safe and works better than a placebo (inactive control) to relieve symptoms.
GenovaAges 18–75 - NCT06962332RecruitingPhase 1
Study of Zanzalintinib in People with Moderate Liver Problems
This trial looks at how a drug called Zanzalintinib acts in people with moderate liver impairment compared to healthy volunteers. It aims to ensure the drug is safe and at the right dose for people with liver issues.
Orlando, FloridaAges 18–75 - NCT06865807Recruiting
Comparing stitches for emergency belly closure
This trial compares two different types of stitches used to close the belly after emergency abdominal surgery. The goal is to find out which stitch leads to better healing and fewer complications.
Santa Cruz de TenerifeAges 18 years+ - NCT06832189RecruitingPhase 1
Testing everolimus and epoetin for liver transplant tolerance
This trial is testing whether a combination of two drugs, everolimus and epoetin, can help liver transplant recipients gradually reduce their anti-rejection medicines. If successful, it may lead to long-term transplant tolerance with fewer side effects.
San Francisco, CaliforniaAges 18 years+ - NCT06781619Recruiting
Plant-based drink study for people at risk of malnutrition
This study tests a plant-based, high-energy, high-protein drink for people who are at medium or high risk of malnutrition. You would replace your current prescribed supplement with either a plant-based or dairy-based drink for 8 weeks to see how it affects your nutrition.
MechelenAges 18 years+ - NCT06769776Recruiting
Drain vs no drain after liver donation surgery
This study compares recovery in living liver donors who either get a surgical drain placed or do not. The goal is to see if skipping the drain leads to better outcomes.
Faridabad, HaryanaAges 18–55 - NCT06704867Enrolling by invitation
High flow nasal cannula vs standard oxygen for endoscopic ultrasound
This trial tests whether a special high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) helps people with a BMI of 35 or higher breathe better during an endoscopic ultrasound procedure compared to standard oxygen. This might reduce breathing complications during the procedure.
Rochester, MinnesotaAges 18 years+ - NCT06648759Recruiting
Vagal stimulator to reduce need for nasogastric tube
This trial tests if a device that stimulates the vagus nerve can help patients avoid needing a nasogastric tube after major abdominal surgery, specifically if they develop a slowdown in bowel function called postoperative ileus.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06302205Recruiting
Home exercise program after liver transplant
This study tests whether a home-based exercise program can help people who recently had a liver transplant. It compares different exercise intensities to see which works best for recovery.
Leuven, Vlaams-BrabantAges 18 years+ - NCT05268432Recruiting
Testing a surgical help system during camera-based operations
This trial tests new technology that helps surgeons during operations that use cameras, robots, or imaging. If you’re having a surgery with these tools and you can consent, you may be able to participate by supporting the in-the-room demonstration.
Dresden, SaxonyAges 18 years+ - NCT05128604Recruiting
Study of EUS-guided bypass for blocked stomach outlet
This nationwide registry follows people with a blocked stomach outlet (gastric outlet obstruction) to see how an endoscopic ultrasound-guided “bypass” procedure works in real life. It may help your care team understand which patients benefit and how safely the procedure can be done.
Badalona, Barcelona, CataloniaAges Any age - NCT04672863Recruiting
Mediterranean diet after a first liver transplant
This study tests whether eating a Mediterranean-style diet after a first liver transplant is safe and helpful for recovery or health. It targets adults who are able to follow a nutrition plan and do not have certain complications or conditions that could interfere with diet changes.
Rochester, MinnesotaAges 18 years+ - NCT06958328RecruitingPhase 3
Higher dose radiation for locally advanced pancreatic cancer
This trial tests whether giving a higher dose of radiation to the pancreas is safe and effective for people with locally advanced pancreatic cancer who have already had chemotherapy without progression.
Gilbert, ArizonaAges 18 years+ - NCT07389824Recruiting
Acupuncture plus mesalazine for ulcerative colitis
This study tests whether adding acupuncture (using small intradermal needles) to the standard medication mesalazine improves outcomes for people with mild-to-moderate ulcerative colitis. Participants receive 12 acupuncture sessions and undergo two colonoscopies to assess the treatment's effect.
Wuhan, HubeiAges 18–75 - NCT05483491RecruitingPhase 1
TCR cell therapy for select metastatic cancers
This Phase 1 trial tests a personalized immune-cell treatment (TCR-T cells) for certain metastatic cancers. It targets cancers that carry a specific marker and requires patients to have a specific immune-system match, aiming to improve cancer control when standard options were already tried.
New Brunswick, New JerseyAges 18 years+ - NCT07652294Enrolling by invitationPhase 2
Long-term safety of antibodies for IBD maintenance
This trial is testing long-lasting antibodies given alone or in combinations to keep IBD under control over the long term. It's for people who already did well in the initial study and want to continue treatment.
Lancaster, CaliforniaAges 18 years+ - NCT07200908RecruitingPhase 3
Comparing brelovitug and bulevirtide for hepatitis delta
This trial tests a new drug, brelovitug, against an existing one, bulevirtide, for people with chronic hepatitis delta. It aims to find a better treatment to lower the virus and protect the liver.
GrazAges 18–99 - NCT07454837RecruitingPhase 2/Phase 3
Switching to brelovitug for chronic hepatitis D patients on bulevirtide
This trial tests if switching from bulevirtide to brelovitug can help people with chronic hepatitis D (CHD). It is for adults who have been on bulevirtide for at least 6 months and still have detectable virus.
GrazAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.