Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT05901519RecruitingPhase 2
Prednisone to protect the liver during focused radiation for liver cancer
This trial tests whether prednisone (an anti-inflammatory steroid) can help protect the liver in people with hepatocellular carcinoma who are getting stereotactic body radiation therapy. It may reduce liver stress from radiation and help you tolerate treatment safely.
Ann Arbor, MichiganAges 18 years+ - NCT07585890Recruiting
Liver Transplant Outcomes With Machine Preservation in Europe
This study collects information about how livers do after transplantation when they've been preserved using machine perfusion—a technique that keeps donor livers in better condition before surgery. Researchers want to understand which preservation methods work best to improve transplant success across Europe.
InnsbruckAges 18 years+ - NCT06215716RecruitingPhase 3
Efruxifermin for NASH/MASH with liver scarring
This study tests a new medicine, efruxifermin, for people with NASH/MASH (fatty liver disease) and moderate liver scarring. It aims to see if the drug can help improve the liver's condition.
Birmingham, AlabamaAges 18–80 - NCT02504853Recruiting
Study food allergy patterns and genetics over time
This study follows people with food allergy and some closely related or healthy people to learn how food allergy (and related conditions) develops over time. It may help researchers find causes and better ways to predict and treat food allergy.
Bethesda, MarylandAges 1 day–99 years - NCT07721181Recruiting
STEP-UP: Higher radiation for recurrent rectal cancer
This trial tests giving a higher dose of radiation to people whose rectal cancer has come back in the pelvis after surgery and cannot be removed. It aims to see if more radiation can help control the tumor when surgery is not an option.
Maastricht, LimburgAges 18 years+ - NCT00575133Recruiting
Study of people with fatty liver disease
This study follows people who have been confirmed to have fatty liver disease seen on a liver sample. It aims to understand the condition over time and how different causes and health factors may affect it.
Zurich, Canton of ZurichAges 18 years+ - NCT02869477Recruiting
Cardia cancer database study
This study collects and stores medical information from people with cardia cancer. The goal is to better understand care and outcomes over time, which may help improve future treatment planning.
Marseille, Bouches-du RhôneAges 18–95 - NCT02518542Recruiting
POEM and stretching treatment for achalasia
This trial looks at a procedure called POEM, followed by prolonged stretching, to treat swallowing problems caused by specific esophagus muscle disorders. If you have the right diagnosis and can safely have an endoscopy, this may help improve how well food moves through your esophagus.
ViennaAges 18 years+ - NCT02038517Recruiting
Liver transplant waitlist study for people without diabetes
This study is for people with end-stage cirrhosis who are on the liver transplant waitlist at this hospital. It aims to understand how getting a liver transplant may affect people with and without diabetes-related issues.
Milan, MIAges 18–65 - NCT02869581Recruiting
Pancreatic tumor patient registry
This study builds a database of people diagnosed with pancreatic tumors. It may help researchers better understand these cancers by collecting medical information over time.
Marseille, Bouches du RhoneAges 18 years+ - NCT02871336Recruiting
Pancreatic cancer surgery patient database study
This study collects information from adults who have surgery for pancreatic cancer. It may help researchers better understand outcomes and improve future care.
Marseille, Bouches du RhoneAges 18 years+ - NCT02869503Recruiting
Colorectal cancer registry study
This study builds a database of people with colorectal cancer. It may help doctors learn from real-world information to improve future care.
Marseille, Bouches du RhoneAges 18–95 - NCT03097952Recruiting
Study of people with long-term hepatitis B in real life
This “real-life” study follows people with chronic hepatitis B to better understand their health over time. It may help researchers learn which factors affect outcomes in everyday care.
Changzhou, JiangsuAges Any age - NCT02422238Recruiting
Study of fatty liver in adults, using MRI and stored samples
This study follows people with nonalcoholic fatty liver disease to better understand the condition. It uses an MRI scan and collects body samples to help researchers study changes over time.
Maastricht, LimburgAges 18–65 - NCT03131427Recruiting
Registry for inherited liver and metabolism-related conditions
This is a study that collects health information and samples (if applicable) from people with certain genetic or metabolic liver diseases. It may help doctors better understand these conditions and improve future care.
Beijing, Beijing MunicipalityAges Any age - NCT02137668RecruitingPhase 1
Testing vancomycin for certain pediatric bile duct conditions
This early-phase study tests whether the antibiotic vancomycin can help children with primary sclerosing cholangitis or biliary atresia, and related gut/bile duct problems. It may work by changing gut bacteria, but you would need to avoid certain medicines beforehand.
Sacramento, CaliforniaAges 2 weeks–40 years - NCT03125980RecruitingPhase 3
Chemo timing before vs after colon cancer surgery
This Phase 3 study compares two schedules of a colon cancer chemo combination: starting before surgery or starting after surgery. It aims to see which timing helps people live longer and lowers cancer coming back.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT03253536Recruiting
Quality of life study after precise liver radiation
This study follows people with liver cancer (hepatocellular carcinoma) to see how their quality of life changes after a focused form of radiation called stereotactic ablative radiation therapy. It does not appear to test a new drug—rather, it measures patient-reported well-being after treatment.
Munich, BavariaAges 18 years+ - NCT03303833Recruiting
Lynch syndrome study following people over time
This study follows adults with Lynch syndrome (an inherited gene change) using regular questionnaires and tracking health over time. It may help researchers understand how the condition progresses and improve care for people with these gene mutations.
WageningenAges 18–80 - NCT03368651RecruitingPhase 3
Testing a pre-surgery infusion to improve liver cancer outcomes
This trial tests whether giving medicine directly into the liver blood vessels before surgery can improve survival for people with liver cancer that has a blockage (tumor in the portal vein). It compares this approach plus surgery versus surgery alone in a randomized study.
Guangzhou, GuangdongAges 18–75 - NCT03250091Recruiting
Stomach precancer check-up study after scope
This study follows people who have had an upper endoscopy (a camera test through the mouth to look at the stomach) to monitor precancerous stomach changes. It may help doctors learn the best way to watch these spots over time and catch problems early.
RigaAges 18 years+ - NCT03463668Recruiting
Testing a specific duodenal stent for duodenal narrowing
This trial is looking back at people with symptoms from narrowing of the duodenum (the first part of the small intestine) who had a specific type of stent placed between 2010 and 2017. It may help doctors understand how well these “uncovered” duodenal stents work over time, and who benefits.
Marseille, Bouches Du RhoneAges 18 years+ - NCT03467581Recruiting
Five-year follow-up after laparoscopic stomach sleeve surgery
This study looks at how people do over the next five years after getting laparoscopic (keyhole) gastric sleeve surgery for obesity. It may help doctors understand long-term outcomes and benefits for future patients.
TartuAges 18–65 - NCT03712774Recruiting
Study of how chemoradiation affects quality of life
This observational study follows people with esophageal cancer to see how their quality of life changes after chemoradiation. It does not change your treatment, but it may help doctors better understand what to expect during and after therapy.
Munich, BavariaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.