Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07542262Enrolling by invitationPhase 2
Low-dose immunotherapy for advanced colorectal and stomach cancer
This study tests a lower dose of immunotherapy in patients with colorectal or stomach cancer that has spread or cannot be removed by surgery. The cancer must have a specific genetic feature (MSI/dMMR). The goal is to see if this approach works well with fewer side effects.
MoscowAges 18 years+ - NCT07537673RecruitingPhase 2
Ear Stimulation Plus Steroid for Chemo Nausea Relief
This trial tests whether stimulating specific points on your ear combined with a steroid medication can reduce nausea and vomiting caused by trastuzumab deruxtecan, a breast cancer drug. The goal is to help you feel better during treatment.
HangzhouAges 18–85 - NCT07538882Recruiting
AI-Assisted Staging and Treatment Planning for Liver Cancer
This trial uses artificial intelligence to help doctors better stage (classify the severity of) and plan treatment for hepatocellular carcinoma, a type of primary liver cancer. Researchers will collect your clinical information and imaging to see if AI can improve decision-making about your care.
Beijing, ChangpingAges 18 years+ - NCT07534800Recruiting
Bougie Cap device for treating swallowing problems from benign esophageal strictures
This study tests a device called Bougie Cap that helps open up benign (non-cancerous) narrowings in the esophagus (food pipe) to relieve swallowing difficulties. If you have a confirmed benign stricture causing trouble swallowing and haven't had endoscopic treatment yet, this study may be right for you.
LyonAges 18 years+ - NCT07537491Recruiting
AI tool to predict surgery outcomes in colorectal cancer
This study uses artificial intelligence to analyze tissue samples from your colorectal cancer surgery to help predict how you'll recover and what your long-term outlook might be. Researchers will examine your tumor tissue under a microscope to build a computer model that could help doctors personalize your care plan.
Brandenburg an der HavelAges 18 years+ - NCT07539727Recruiting
Intestinal ultrasound to predict Crohn's disease flare-ups
This study tests whether a special ultrasound of the intestines can predict when Crohn's disease will flare up again in patients whose disease is currently well-controlled. If successful, doctors could catch flare-ups earlier and adjust treatment before symptoms worsen.
Guangzhou, GuangdongAges 18–70 - NCT07541924Recruiting
Image-Guided Colonoscopy: Patient Experience and Doctor Efficiency
This study tests whether using CT scan images to guide doctors during colonoscopy (a camera exam of your colon) improves how well the procedure goes and reduces doctor stress. You'll answer questions about your experience before and after the procedure.
Beijing, Beijing MunicipalityAges 18–80 - NCT07542171Recruiting
Outcomes after incomplete early colon cancer removal
This study follows patients who had early colon cancer removed by endoscopy (a camera procedure) but the removal was incomplete. Researchers will track what happens when patients either have surgery afterward or are closely watched instead, to understand the best next steps.
Guangzhou, GuangdongAges 18–75 - NCT07535021Recruiting
Mandala Art Therapy to Help With Cancer Surgery Recovery
This study tests whether creating mandala art (decorative circular patterns) helps colorectal cancer patients cope better after surgery. Researchers want to see if art therapy reduces stress, builds emotional strength, and improves your ability to handle the surgery and recovery.
SivasAges 18–74 - NCT07542652Recruiting
Microplastics and stomach cancer risk study
This research examines whether tiny plastic particles in the body are linked to stomach cancer development. Researchers will compare microplastic exposure in people with different stages of stomach issues—from inflammation to early changes to cancer—to understand if plastics play a role.
Xi'an, ShaanxiAges 18–75 - NCT07540637Recruiting
Study of how well patients take hepatitis B medication with app support
This study tests whether a smartphone app called HBVCare helps patients with chronic hepatitis B stick to their treatment plans. Researchers will track how well the app helps patients take their medicines on time and understand what makes treatment adherence easier or harder.
HanoiAges 18 years+ - NCT07537348RecruitingPhase 2
Leucine-restricted diet with chemotherapy for advanced stomach cancer
This study tests whether a special diet low in leucine (an amino acid) combined with chemotherapy and immunotherapy can safely treat advanced stomach cancer that has spread. Researchers want to see if this dietary approach helps the treatment work better and reduces side effects.
Jinan, ShandongAges 18–70 - NCT07540026Recruiting
Comparing Two Treatments for Bleeding Stomach Tumors
This trial tests two medications—tranexamic acid and sucralfate—applied during an endoscopy (a camera procedure) to stop bleeding caused by tumors in the upper digestive tract. The goal is to see which treatment works better at controlling the bleeding.
Tainan, Not Required For This CountryAges 18 years+ - NCT07536841Recruiting
Testing New Criteria for Autoimmune Pancreas Inflammation
This study validates a new diagnostic tool (Odesa Criteria 2026) to help doctors accurately identify autoimmune pancreatitis—a rare condition where the body attacks the pancreas. If you're being evaluated for possible pancreas inflammation, this trial may help confirm whether you have this specific type.
OdesaAges 18 years+ - NCT07537205Enrolling by invitation
Nurse-led preparation program for liver cancer surgery
This study tests whether a personalized preparation program led by nurses before liver cancer surgery helps patients recover better and have fewer complications. The program is designed specifically for people scheduled to have part of their liver removed.
Shanghai, XuhuiAges 18–84 - NCT07537660RecruitingPhase 2
Ear Stimulation and Steroids for Chemotherapy Nausea
This trial tests whether stimulating specific points on your ear, combined with a steroid medication, can reduce nausea and vomiting caused by two chemotherapy drugs (gemcitabine and paclitaxel) used to treat pancreatic cancer. The goal is to help you tolerate chemotherapy better.
HangzhouAges 18–85 - NCT07537699RecruitingPhase 2
Ear Stimulation and Steroid for Chemo-Related Nausea
This trial tests whether stimulating specific points on your ear, combined with a steroid medication, can reduce nausea and vomiting caused by chemotherapy drugs (docetaxel and cyclophosphamide) given after breast cancer surgery. Many patients experience these side effects, and the study wants to see if this non-drug approach helps.
HangzhouAges 18–85 - NCT07534241Recruiting
Reishi Mushroom for Fatty Liver Disease
This study tests whether reishi mushroom (a type of fungus) can improve liver health in people with metabolic dysfunction-associated fatty liver disease—a condition where fat builds up in the liver. Researchers want to see if this natural supplement can reduce liver inflammation and improve blood sugar and cholesterol levels.
LahoreAges 35–65 - NCT07536191Recruiting
Gallbladder Drainage Methods for Acute Cholecystitis
This trial compares two ways to drain an inflamed gallbladder in patients who cannot safely have surgery: one approach goes through the stomach wall using ultrasound guidance, and the other goes through a bile duct opening. The goal is to find which method works better and causes fewer problems.
AichiAges 18 years+ - NCT07537998RecruitingPhase 2/Phase 3
Intestinal Fluid Recycling to Reduce Bowel Problems After Rectal Cancer Surgery
This trial tests a surgical technique that recycles intestinal fluids during rectal cancer surgery to help prevent bowel dysfunction and frequent bowel movements after surgery. If you've had mid-to-low rectal cancer removed and created a temporary opening (stoma), this study may help improve your quality of life.
Guangzhou, GuangdongAges 18–75 - NCT07537361RecruitingPhase 2
Leucine-Restricted Diet With Chemotherapy for Gastric Cancer
This trial tests whether a special diet low in leucine (an amino acid) combined with chemotherapy and immunotherapy drugs can help treat locally advanced gastric cancer before surgery. The goal is to see if this combination is safe and more effective than standard treatment alone.
Jinan, ShandongAges 18–70 - NCT07539155RecruitingPhase 1/Phase 2
MMR Vaccine Injection for Advanced Pancreatic Cancer
This trial tests whether injecting an MMR (measles, mumps, rubella) vaccine directly into a pancreatic tumor can help your immune system fight the cancer. You're eligible if your pancreatic cancer cannot be surgically removed after standard chemotherapy and radiation treatment.
Little Rock, ArkansasAges 18 years+ - NCT06748352Recruiting
Robot-assisted scope removal for early stomach cancer
This study tests a new robot-assisted tool to remove early-stage stomach cancer or precancerous cells through a scope (endoscope) without open surgery. The goal is to see if it is safe and effective at removing the abnormal tissue completely.
Jinan, ShandongAges 18–80 - NCT06749990Recruiting
Alcohol relapse risk after liver transplant
This study looks at why some people with alcohol-related liver disease start drinking again after a liver transplant. It aims to find factors that increase or decrease that risk.
BolognaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.