Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,366 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2167
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia72
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke19
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,366 total
- NCT05108896Recruiting
Testing breathing and swallowing recovery after ICU breathing support
This study looks at aspiration (food or liquid going “the wrong way” into the airway) in people who survived a serious ICU breathing problem. It may help doctors better support safe swallowing and breathing recovery after being on a breathing machine.
Stanford, CaliforniaAges 18 years+ - NCT05119842Recruiting
Implant study for permanent voice weakness from vocal cord closure
This study tests a voice implant device in people with permanent vocal cord weakness (UVFP) who have trouble closing their vocal cords. It aims to improve voice strength and reduce voice-related burden, while checking safety over the study period.
Phoenix, ArizonaAges 18–80 - NCT05126160Recruiting
MRI-based imaging to guide treatment in nasopharyngeal cancer
This study uses special MRI images (and computer “radiomics” scores) to better understand nasopharyngeal cancer. The goal is to help doctors choose the most appropriate treatment for people with newly diagnosed cancer.
Wuhan, HubeiAges 18–70 - NCT05129748RecruitingPhase 2
Prevent hearing damage during cisplatin chemotherapy
This Phase 2 trial tests whether sodium thiosulfate and mannitol can reduce hearing damage (ototoxicity) in adults receiving cisplatin chemotherapy. It may help protect hearing while you get cancer treatment.
Toronto, OntarioAges 18 years+ - NCT05147844RecruitingPhase 2
Toripalimab plus radiation for limited-spread nose cancer
This Phase 2 trial studies whether adding toripalimab (an immune therapy) to radiation can control nasopharyngeal cancer that has spread only to a few places. It may help by boosting the immune system while the radiation treats the tumor sites.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT05150093Recruiting
Deep brain stimulation for voice tremor or dystonia
This trial studies deep brain stimulation (a surgically placed device that sends electrical signals) to reduce voice tremor or laryngeal dystonia. You may be considered if your symptoms are persistent despite medication and you can complete the study tasks and pre-surgery testing.
Boston, MassachusettsAges 18–80 - NCT05150106Recruiting
Study brain and voice patterns in laryngeal dystonia
This study looks at how the brain and voice system work in people with laryngeal dystonia or voice tremor, and compares them with healthy volunteers. The goal is to better describe different “types” (phenotypes) so future care can be more targeted.
Boston, MassachusettsAges 18–80 - NCT05157685RecruitingPhase 3
Azithromycin for chronic pus-filled sinus inflammation
This Phase 3 trial tests whether the antibiotic azithromycin can improve chronic sinus problems where there is persistent pus and swelling. It’s for adults who have not improved despite at least two prior antibiotics.
BordeauxAges 18–70 - NCT05187091RecruitingPhase 3
Radiation plan that tries to protect swallowing organs
This Phase 3 study compares a standard radiation approach versus a modified approach designed to spare key swallowing and aspiration (choking) related areas and one salivary gland. It may help reduce treatment side effects that affect swallowing and quality of life for certain head and neck cancer patients.
Jhajjar, HaryanaAges 18–70 - NCT05190718Recruiting
Pharyngeal electrical stimulation for swallowing trouble after brain injury
This trial tests a non-drug therapy that uses gentle electrical stimulation to help people swallow safely when swallowing is affected by certain brain or nerve conditions. If you qualify, you may receive this approach to improve swallowing and reduce choking risk.
Tulln, Low AustriaAges 18 years+ - NCT05203302Recruiting
Testing new computer coding ideas for cochlear implant users
This study is developing and testing new “coding strategies” for children who have cochlear implants and for people with normal hearing. It may help improve how hearing input is processed or used, and could lead to better support for cochlear implant users.
New York, New YorkAges 6–80 - NCT05216770RecruitingEarly Phase 1
Brain-scan study of voice dystonia and tremor
This early study uses brain and voice-related testing to better understand what is happening in the brain in people with laryngeal dystonia or voice tremor. The results may help scientists learn more about these conditions and how they differ from healthy voices.
Boston, MassachusettsAges 18–80 - NCT05220982Recruiting
Voice therapy help through a phone app and telepractice
This study tests a voice-therapy program delivered through live online sessions (telepractice) plus a smartphone or tablet app. It may help people improve their voice use safely and effectively, especially teachers who have voice complaints.
West Chester, PennsylvaniaAges 18 years+ - NCT05241262RecruitingPhase 1
N-acetylcysteine for people with m.3243A>G and low brain glutathione
This trial tests whether the supplement N-acetylcysteine (NAC) can help people who have the m.3243A>G mitochondrial genetic change and low levels of a brain chemical called glutathione. The study aims to see if raising glutathione in the brain is safe and potentially beneficial for these patients.
New York, New YorkAges 18–80 - NCT05260307Recruiting
Improving hearing of multiple voices and speech understanding
This study tests ways to improve how people perceive space in sound and understand speech when many voices are talking at once. It may help adults with normal hearing or hearing loss better follow conversations in noisy, “overlapping voices” situations.
Boston, MassachusettsAges 18–80 - NCT05281952Recruiting
Tested ways to treat severe nosebleeds after failed packing
This study looks at different management strategies for severe nosebleeds when the initial packing method has not worked for over 48 hours. It also measures the cost/benefit of these approaches to help improve care.
ToulouseAges 18 years+ - NCT05287022Recruiting
Nasal nitric oxide test to improve primary ciliary dyskinesia care
This study tests whether a breathing test called nasal nitric oxide can help improve care for people with primary ciliary dyskinesia (PCD) or related lung/sinus problems. The goal is to see if the test can better guide diagnosis and treatment planning.
Little Rock, ArkansasAges 2–99 - NCT05287841Recruiting
Battten graft during septum and turbinate surgery
This study tests whether adding a “batten graft” during septoplasty and turbinate reduction improves nasal breathing and nasal airflow. It aims to see if the graft helps when breathing blockage is mainly from the septum, enlarged turbinates, and the outside nasal valve collapsing.
Poplar Bluff, MissouriAges 18 years+ - NCT05290194RecruitingPhase 2
New metastatic nasopharyngeal cancer trial with radiotherapy and PD-1
This trial studies whether adding targeted radiotherapy (SBRT) to PD-1 immunotherapy plus capecitabine can improve outcomes for people with newly diagnosed metastatic nasopharyngeal cancer. You may be eligible if your cancer has responded at least to “stable disease” after an initial chemo-immunotherapy course.
Zhuhai, GuangdongAges 18–70 - NCT05305131RecruitingPhase 2
Testing chemotherapy with or without extra cancer medicines for nasopharyngeal cancer
This Phase 2 study compares standard chemotherapy (gemcitabine plus cisplatin) against the same chemotherapy plus pembrolizumab and bevacizumab. It aims to see which combination works better for EBV-positive nasopharyngeal cancer before any prior treatment.
SingaporeAges 1.8 years–99 years - NCT05307939RecruitingPhase 2
Using tumor DNA tests to time treatment for HPV throat cancer
This study checks a blood test that looks for HPV tumor DNA to help doctors decide when to start routine treatment after surgery. It may help some people avoid starting treatment too early or too late based on how the test changes after the operation.
Miami, FloridaAges 18 years+ - NCT05312983Recruiting
Testing new hearing tests to better diagnose age-related hearing loss
This study is developing a set of hearing tests to more precisely identify age-related hearing loss. It may help you (or the study team) better understand what type of hearing problem you have and how to guide next steps.
ParisAges 18 years+ - NCT05317390Recruiting
Tests an AI tool to diagnose isolated dystonia
This trial checks whether an AI (software) called DystoniaNet can accurately identify isolated dystonia using information from your evaluation, and compares its results to standard diagnosis. If you have focal, segmental, or generalized dystonia, this study may help improve faster and more accurate diagnosis in the future.
Boston, MassachusettsAges Any age - NCT05318417Recruiting
Cochlear implant study for one-sided deafness
This study checks whether cochlear implantation is safe and effective for people who have very poor hearing in one ear (single-sided deafness) while the other ear hears normally or nearly normally. You may be enrolled if you meet specific hearing test and health/surgery readiness requirements.
Palo Alto, CaliforniaAges 5 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,366 recruiting otolaryngology studies from the U.S. registry right now, out of 2,207 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.