Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT07101744RecruitingPhase 2
Drug combination study for advanced nasopharyngeal cancer
This trial tests a combination of three drugs for people with nasopharyngeal cancer that has come back or spread and stopped responding to first-line chemotherapy. It aims to see if this new combination can help when standard treatment no longer works.
GuangdongAges 18–70 - NCT07100704RecruitingPhase 2
Nivolumab for recurrent olfactory neuroblastoma
This trial tests the drug nivolumab for people with a rare nasal tumor (olfactory neuroblastoma) that has come back or spread and cannot be treated with surgery or radiation. You must have already tried chemotherapy and it stopped working. The goal is to see if nivolumab can shrink the tumor or slow its growth.
Kashiwa, ChibaAges 18 years+ - NCT07098767Recruiting
Swallowing Ultrasound Study for People with Swallowing Difficulty
This trial tests whether an ultrasound can reliably evaluate swallowing problems. It aims to find a non-invasive way to assess your swallowing, which could help guide your care.
TaipeiAges 18 years+ - NCT06069531Recruiting
Probiotic or White Pomegranate for Vaginal Health
This study tests whether taking a probiotic (Lactobacillus Johnsonii) or a white pomegranate extract can improve vaginal health in women with an imbalance in vaginal bacteria. It aims to find a natural way to support a healthy vaginal environment.
TaichungAges 20–45 - NCT06674356Recruiting
Chin tuck exercise for swallowing after stroke
This trial tests a simple neck exercise (chin tuck against resistance) to help people who have trouble swallowing after a recent stroke. The goal is to see if this exercise improves swallowing safety and strength.
TaipeiAges 18–100 - NCT06456255RecruitingPhase 2/Phase 3
Numbing injection study for first-time sinus surgery
This study tests a numbing medication (bupivacaine with epinephrine) injected during your first sinus surgery to see if it helps reduce pain after the procedure. It may be an option if you have not had sinus surgery before and are generally healthy.
Vancouver, British ColumbiaAges 19 years+ - NCT06750302RecruitingPhase 1/Phase 2
Penthrox vs placebo for sinus surgery pain
This trial tests if a pain reliever called Penthrox (methoxyflurane) works better than a placebo for pain during minor sinus procedures. If you are having a simple sinus surgery or coblation procedure, you may be able to join.
Vancouver, British ColumbiaAges 19 years+ - NCT07094685RecruitingPhase 2
Ivonescimab before surgery for head and neck cancer
This study tests a new immunotherapy drug called ivonescimab given before surgery for people with advanced head and neck cancer. The goal is to see if it helps shrink the tumor and improve outcomes.
Ann Arbor, MichiganAges 18 years+ - NCT07085988RecruitingPhase 2
Nutrition help for nasopharyngeal cancer patients on chemoradiation
This trial tests if special nutritional management during concurrent chemoradiotherapy can improve outcomes for people with nasopharyngeal cancer. If you are getting both chemotherapy and radiation as your main treatment, this study may help you maintain better nutrition.
Nanchang, JiangxiAges 18 years+ - NCT07093749Recruiting
Antibiotics and symptom tracking in children
This study looks at how children with common infections feel while taking antibiotics. The goal is to better understand symptom patterns during treatment.
Melbourne, VictoriaAges 4–17 - NCT06660082Recruiting
Early rehab after inner ear tumor surgery
This trial tests if early rehabilitation using a head movement test can help people recover balance after surgery for an inner ear tumor called a vestibular schwannoma.
BronAges 18–65 - NCT07079488Enrolling by invitation
Vestibular function and motor development in young children
This study looks at how the balance system (vestibular function) develops in young children and how it relates to their motor skills. It may help understand typical and atypical development.
StockholmAges 5 months–3 years - NCT07080996Enrolling by invitationPhase 3
Biofeedback tongue strengthening for better swallowing
This trial tests whether a biofeedback tongue strengthening program can improve tongue pressure and swallowing ability in older adults. It may help if you have weak tongue muscles but no other conditions affecting your tongue.
Salaya, Changwat Nakhon PathomAges 60 years+ - NCT07076524Recruiting
Muscle wasting and swallowing in critically ill patients
This study looks at muscle loss and swallowing problems in very ill patients on breathing machines in the intensive care unit. It aims to understand these issues better, which could help improve care for future patients.
LondonAges 18 years+ - NCT07081399RecruitingEarly Phase 1
Care plan to prevent complications after tube removal
This trial tests a special care plan for adults who are on a breathing machine (ventilator) for the first time. The goal is to see if this plan helps prevent problems after the breathing tube is removed.
Damanhūr, EgyptAges 18–60 - NCT07085234RecruitingPhase 2
New drug combo before radiation for advanced nasopharyngeal cancer
This trial tests a new immunotherapy drug (QL1706) combined with chemotherapy before standard radiation for advanced nasopharyngeal cancer. It aims to shrink tumors and improve outcomes.
Xiamen, FujianAges 18–65 - NCT06897501Recruiting
Comparing breathing tubes for voice box protection during esophagectomy
This trial compares two types of breathing tubes used during robot-assisted esophageal cancer surgery. One tube blocks one lung (double-lumen tube) and the other tube uses a smaller blocker (bronchial blocker); researchers want to see which causes fewer voice box nerve injuries after surgery.
SeoulAges 19 years+ - NCT06981494Recruiting
Study of two medicines for relaxing blood pressure during ear and nose surgery
This trial tests if adding a second medicine, ketamine, to dexmedetomidine helps control blood pressure better during ear or nose surgery. It may lead to safer and smoother anesthesia for patients needing controlled low blood pressure.
SohagAges 18–60 - NCT06499805Recruiting
Barriers and helpers to using OTC hearing aids
This study looks at what helps or makes it harder for adults to successfully use over-the-counter hearing aids. It focuses on people who have mild to moderate hearing loss in both ears and have never tried a hearing aid.
Iowa City, IowaAges 18–89 - NCT06912711RecruitingPhase 2
Chemo before and after surgery for recurrent nasal cancer
This trial tests giving chemotherapy before and after surgery for people whose nasal cancer has come back. The goal is to see if this approach helps remove the cancer more effectively and prevents it from returning again.
Guangzhou, GuangdongAges 18–65 - NCT07071298Recruiting
AERA pediatrics registry study
This registry tracks children who have a procedure called endoscopic transforaminal balloon dilation (ETBD) using the AERA device. The goal is to learn more about how this treatment works for young patients.
Palo Alto, CaliforniaAges Up to 18 years - NCT07070089Recruiting
Stent implant for severe heartbeat-synchronized ear ringing
This trial tests whether placing a small mesh tube (stent) in a narrowed brain vein can stop severe, pulse-synchronous tinnitus—a whooshing sound that matches your heartbeat. It is for people whose tinnitus is very bothersome and has not improved with other treatments.
Ottawa, CanadaAges 18–80 - NCT07071480Recruiting
Noninvasive sound therapy for chronic tinnitus
This trial tests a noninvasive device to reduce the loudness and burden of chronic tinnitus. It may help people who have constant tinnitus and are not currently using other treatments.
Miami, FloridaAges 18 years+ - NCT07067268RecruitingPhase 2
Tislelizumab and capecitabine for nasopharyngeal cancer with remaining EBV DNA
This trial tests a combination of two drugs, tislelizumab and capecitabine, for people with nasopharyngeal cancer who still have detectable EBV DNA in their blood after finishing radiation therapy. The goal is to see if this treatment can help clear the virus and improve outcomes.
Shanghai, ChinaAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.