Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,366 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2167
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia72
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke19
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,366 total
- NCT05719207Recruiting
Balloon treatment for long-lasting clogged ear tube symptoms
This trial tests whether balloon dilation of the Eustachian tube can improve symptoms like ear pressure, muffled hearing, pain, ringing, and popping. It’s for people whose symptoms have lasted for months (or are triggered by pressure changes) and haven’t improved with usual non-surgical treatments.
Calgary, AlbertaAges 18 years+ - NCT05460689Recruiting
Phone app support for families before pediatric ear-nose-throat surgery
This trial tests whether a mobile phone app can better support caregivers of children going into tonsil and/or adenoid surgery (sometimes with ear tube placement) around the time of the operation. It may help families feel more informed and prepared before and after surgery.
TriesteAges 2–10 - NCT05547152Recruiting
Virtual Reality for Facial Paralysis Recovery
This trial tests whether a virtual reality self-rehabilitation program can help people recover movement and reduce unwanted muscle contractions after recent facial paralysis. You would practice facial exercises using VR technology at home to retrain your facial muscles.
Amiens, PicardieAges 18 years+ - NCT05482022Recruiting
Test speaking valve effects for people with tracheostomy and brain injury
This study checks whether a speaking valve changes breathing, swallowing, and voice in people who have a tracheostomy after a brain injury. It may help doctors find safer ways to improve communication and function for people who are in a minimal conscious or unresponsive state.
RaananaAges 18 years+ - NCT05554133Recruiting
Optical guidance study for oral biopsy planning
This study tests a “precision optical” method to help guide an oral biopsy in people with abnormal or potentially cancerous mouth spots. It may help clinicians target the right area to sample, making diagnosis more accurate.
Houston, TexasAges 18 years+ - NCT05626621RecruitingPhase 4
Nasal rinse with allergy sprays vs regular nasal sprays
This study compares two types of allergy-related nasal treatment: a rinse with azelastine and mometasone versus standard nasal sprays. It aims to see which approach works better for people with long-term (chronic) rhinitis over 6 months.
Evanston, IllinoisAges 18 years+ - NCT05547633Recruiting
Study to monitor and treat sinus problems in wet AMD
This study looks at whether sinus infections or inflammation affect people who have “wet” age-related macular degeneration and are already receiving regular eye injections. It may help them find better ways to detect and manage sinusitis while continuing AMD care.
ParisAges 18 years+ - NCT05549167RecruitingPhase 3
Sirolimus for children with juvenile nasal blood tumors
This trial tests whether sirolimus can shrink or control juvenile nasopharyngeal angiofibroma in children and teens, and checks its safety. It may help families who cannot rely only on surgery, especially for larger or hard-to-treat tumors.
MoscowAges 7–18 - NCT05495490Recruiting
Bone-building vs sinus lift for delayed dental implants
This trial compares two surgical methods to help place dental implants in the upper back jaw when there isn’t enough bone height. It may help you and your dentist choose the safest approach to create enough support for the implant.
AsyutAges 18–40 - NCT05350540RecruitingPhase 2
ICG dye to lower leakage after salvage laryngectomy surgery
This study tests whether using a special fluorescent dye (ICG) during salvage laryngectomy can reduce the chance of a surgical “leak” (a fistula) in the throat area. If you’re having salvage surgery after prior radiation, it may help surgeons better see where to place tissue coverage to prevent complications.
Toronto, OntarioAges 18 years+ - NCT05360212Recruiting
Fitting a new cochlear implant sound processor using CT anatomy
This study tests a way to set up (fit) a new cochlear implant sound processor using CT scan anatomy. It may help people hear better by tailoring how electrodes are mapped to their inner ear shape.
Madrid, MadridAges 18 years+ - NCT05285566RecruitingPhase 4
Pain control during rib cartilage nose surgery
This trial studies a way to better control pain for people who need nasal surgery that uses rib cartilage. It may help reduce discomfort during the procedure and recovery.
Rochester, MinnesotaAges 18 years+ - NCT05578560Recruiting
Virtual reality rehab after vestibular schwannoma surgery
This trial studies whether virtual reality (VR) exercises can help people recover movement and balance after surgery for a vestibular schwannoma. If you’re eligible, you may be asked to use VR as part of your rehabilitation program.
PragueAges 18 years+ - NCT04940000Recruiting
Remote video speech therapy check-ins for head and neck cancer
This trial tests whether video call speech therapy consultations can work well for people with head and neck (ORL) cancer who need speech/voice support during treatment. It may help you get care closer to home while still being guided by speech therapists.
ToulouseAges 18 years+ - NCT04755855Recruiting
Study of treatment outcomes in sinonasal cancer patients
This study follows people who have sinonasal cancer and are being treated at Mayo Clinic. It looks at how patients do over time, which may help improve care for future patients.
Rochester, MinnesotaAges 4 weeks–99 years - NCT05246267Recruiting
Dupilumab study for chronic sinus disease with nasal polyps
This study looks at how dupilumab (an injection medicine) helps people with chronic rhinosinusitis with nasal polyps, including how well it works across different ethnic backgrounds. You may be able to join if you’ve been diagnosed and you can get dupilumab through insurance or a patient assistance program.
The Bronx, New YorkAges 18–99 - NCT05000892RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for salivary cancer
This trial studies giving an immunotherapy drug (sintilimab) plus two chemotherapy medicines before surgery to shrink salivary gland cancer. The goal is to improve how well the cancer responds and is controlled, while still aiming for a cure through surgery.
Guangzhou, GuangdongAges 18–80 - NCT04853173Recruiting
Testing pain-relief methods for adult tonsillectomy
This trial looks at how best to control pain for adults having tonsil removal (tonsillectomy) on an outpatient basis. It may help find a pain plan that works well and is safe for people like you.
BesançonAges 18 years+ - NCT04997577Recruiting
Study of speech listening with high mental effort
This study tests how well you can understand speech when the task is mentally demanding. It may help researchers understand hearing and brain processing in older adults.
College Park, MarylandAges 65–85 - NCT04743362Recruiting
Noninvasive scans for skin and mouth lesions
This trial tests noninvasive imaging methods to look at skin and mouth (mucosal) conditions. It may help doctors better see changes in these areas without taking tissue samples.
New York, New YorkAges Any age - NCT04807660Recruiting
Testing germs in children with ear drainage
This study checks what germs are causing ear drainage (“otorrhea”) in children. The results may help doctors choose the right treatment.
CréteilAges 3 months–15 years - NCT04670172Recruiting
Chronic sinusitis patient registry using a phone app
This study builds a real-world record of symptoms and outcomes in people with chronic sinusitis. You may help by using a smartphone app to report your symptoms over time.
GrazAges 18 years+ - NCT04966481RecruitingPhase 3
Palbociclib plus cetuximab versus cetuximab alone
This trial studies whether adding palbociclib to cetuximab works better than cetuximab by itself for head and neck cancer that is growing again after an anti–PD-1/PD-L1 treatment. It is for people whose tumor has a specific gene change (CDKN2A loss) and who have not had too many prior treatments.
Worthington, MinnesotaAges 18 years+ - NCT04365036RecruitingPhase 3
Check if PD-1 plus chemo-radiation helps early nasal lymphoma
This trial studies whether adding toripalimab (an immune therapy that targets PD-1) to standard chemo-radiation works better for newly diagnosed early-stage nasal natural killer/T-cell lymphoma. It’s designed to see if the combined treatment can improve outcomes while staying safe.
Guangzhou, GuangdongAges 18–75
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,366 recruiting otolaryngology studies from the U.S. registry right now, out of 2,207 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.