Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,067 recruiting studies in this area right now.
By phase
- Not applicable3,005
- Phase 21,060
- Phase 1794
- Phase 1/Phase 2441
- Phase 3435
- Phase 4233
- Phase 2/Phase 399
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma328
- Asthma194
- Lymphoma179
- Type 1 Diabetes132
- Rheumatoid Arthritis131
- Atopic Dermatitis122
- Systemic Lupus Erythematosus121
- Acute Lymphoblastic Leukemia118
- HIV Infections105
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases79
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Hodgkin Lymphoma64
- Diabetes Mellitus, Type 163
- Leukemia63
- Type 1 Diabetes Mellitus63
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca64
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic50
- City of Hope Medical Center49
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California498
- Maryland198
- Alabama178
- Florida151
- Arizona150
- Massachusetts118
- New York114
- Texas112
- Illinois84
- Colorado81
Recruiting studies6,067 total
- NCT03918421Recruiting
IgM-MAG neuropathy study using immunoglobulin M treatment
This study looks at a treatment made from immune proteins (immunoglobulin M) to treat neuropathy caused by anti-MAG antibodies. It may help improve nerve symptoms in people with this specific type of nerve condition.
BronAges 18 years+ - NCT04239703Recruiting
Kidney transplant biopsy study using blood test clues
This study looks at kidney transplant patients who are getting a kidney biopsy for usual clinical reasons. It tests whether special blood test results (from a sample taken as part of the study) can help spot transplant kidney problems earlier or more accurately.
Tampa, FloridaAges Any age - NCT04182984Recruiting
Compare immunosuppressant medicines for eye-only myasthenia gravis
This real-world study looks at how different immunosuppressant medicines work for people with non-thymoma ocular myasthenia gravis (eye symptoms due to MG). It may help doctors understand which treatments control symptoms best in everyday care.
Xi'an, ShaanxiAges 18–75 - NCT04195633RecruitingPhase 2
Haploidentical donor stem cell transplant to treat blood cancers
This Phase 2 trial tests whether a specific stem cell transplant method (from a related “half-matched” donor) plus conditioning chemo and radiation can improve outcomes for several blood cancers. It may help people whose cancer is in remission but still considered high risk, or those who have had limited response after prior treatment.
Seattle, WashingtonAges 6 months+ - NCT04195347RecruitingPhase 1/Phase 2
CM4620 to lessen pancreatitis after asparaginase
This study tests CM4620 to reduce how severe pancreatitis becomes in children and young people with leukemia/lymphoma who develop pancreatitis after receiving a drug called asparaginase. It aims to improve outcomes by calming the inflammation of the pancreas.
Charlotte, North CarolinaAges Up to 21 years - NCT04223765RecruitingPhase 1
Testing a new CAR T-cell treatment for kappa cancers
This Phase 1 trial studies a lab-made immune therapy (CAR T cells) that targets “kappa” markers on certain lymphomas and CLL/SLL. It’s for people whose cancer has come back or didn’t respond to standard treatments, aiming to improve control of the disease.
Chapel Hill, North CarolinaAges 18 years+ - NCT04198740Recruiting
Test tear fluid and eye chemistry patterns in eye surface diseases
This study looks at tiny chemical patterns in tear fluid to better understand different causes of eye surface problems. Your participation may help researchers compare healthy eyes with conditions like dry eye, infections, or allergies.
Montreal, QuebecAges 18 years+ - NCT04211259RecruitingEarly Phase 1
Loratadine to reduce bone pain during stem cell collection
This early trial studies whether loratadine (an allergy medicine) can reduce bone pain caused by G-CSF, which is used to help your body collect stem cells. If you have multiple myeloma and are preparing for stem cell mobilization, this may make treatment-related bone pain more tolerable.
New Brunswick, New JerseyAges 18 years+ - NCT04210791Enrolling by invitation
Stem cell transplant using your own cells for AL amyloidosis
This trial tests whether an autologous stem cell transplant (using your own stem cells) can help people with newly diagnosed AL amyloidosis. It may be offered to help your body reset abnormal disease-producing cells, based on your health and test results.
Nanjing, JiangsuAges 18–75 - NCT04157361Recruiting
Non-invasive lung testing in asthma and cystic fibrosis
This trial studies how well a non-invasive lung test can show lung involvement in people with asthma (especially IgE-related asthma) and people with cystic fibrosis. You might benefit by getting extra lung assessments without invasive procedures.
OlomoucAges Any age - NCT04197596RecruitingPhase 1/Phase 2
BK infection immune-cell treatment after transplant or weak immunity
This Phase 1/2 study tests lab-made immune cells that specifically target BK virus in people whose BK infection keeps coming back or doesn’t improve. It may help by boosting the body’s ability to clear the virus, especially when standard antiviral treatments don’t work or can’t be tolerated.
San Francisco, CaliforniaAges 1 month–79 years - NCT04160910RecruitingPhase 2
Studying 5HTP to manage asthma symptoms in kids
This Phase 2 study tests whether 5HTP can help regulate asthma in children and teens who have mild to moderate asthma linked to allergies. It may be an option if your symptoms are allergy-related and you can follow study visits and questionnaires.
Indianapolis, IndianaAges 8–18 - NCT04170244Recruiting
Skin microbiome study in atopic dermatitis and psoriasis
This study looks at the skin’s germs (“microbiome”) in people with atopic dermatitis (eczema) or psoriasis. It may help researchers better understand what’s going on on the skin and how that might relate to disease severity.
Rochester, New YorkAges 13 years+ - NCT04240522Recruiting
Long-term study of eczema and related allergies
This observational study follows people with eczema (atopic dermatitis) and sometimes related allergies over time, even if they keep their usual medical treatments. It may help researchers better understand how these conditions change and what factors relate to symptoms.
Zurich, Canton of ZurichAges 1–85 - NCT04242095Recruiting
Immunotherapy side effects research study
This study collects blood, stool, and tissue samples from people who have had side effects from immunotherapy (a type of cancer treatment that helps your immune system fight cancer). It aims to learn more about these side effects, so doctors can better manage them in the future.
Anchorage, AlaskaAges Any age - NCT04186520RecruitingPhase 1/Phase 2
CAR T-cell treatment for hard-to-treat B-cell lymphomas
This trial studies a type of lab-made immune cell therapy (CAR T) using cells called CAR-20/19-T. It is for adults with relapsed or refractory B-cell cancers, aiming to reduce or eliminate lymphoma in people whose disease has come back or not responded to standard treatments.
Milwaukee, WisconsinAges 18–80 - NCT04240054RecruitingPhase 2
Study drugs before transplant for myeloma with kidney problems
This Phase 2 trial tests whether a combination of anti-myeloma medicines given before stem cell transplant works well and is safe for people with multiple myeloma who also have kidney problems. It may help control the myeloma and prepare you for the transplant.
Milwaukee, WisconsinAges 18 years+ - NCT04169737RecruitingPhase 2
Acalabrutinib and venetoclax for high-risk CLL or SLL
This trial tests whether acalabrutinib and venetoclax (with or without early obinutuzumab) can control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is mainly for people whose disease is high-risk, has come back, or did not respond to earlier treatment.
Houston, TexasAges 18 years+ - NCT04237623RecruitingPhase 2
GM-CSF after transplant using a matched related donor
This Phase 2 study tests whether giving a medicine called GM-CSF after an allogeneic transplant (using a matched related donor) can improve outcomes. Participants must meet health and donor-matching requirements and be eligible to safely receive the treatment and consent to the study.
Atlanta, GeorgiaAges 18–78 - NCT04234048RecruitingPhase 1
ST-001 trial for stubborn T-cell lymphoma that came back
This Phase 1 trial tests ST-001, an experimental treatment, for T-cell lymphomas that have returned or did not respond to prior therapy. It aims to find a safe dose and see whether it can shrink or control the lymphoma.
Scottsdale, ArizonaAges 18 years+ - NCT04145401Enrolling by invitation
Long-term follow-up for a specific knee revision implant
This study tracks how well a particular knee revision implant performs over many years. It may help you by closely monitoring your knee after revision surgery and adding to long-term safety and performance data.
Englewood, ColoradoAges 21 years+ - NCT04202341Recruiting
Registry for people with generalized myasthenia gravis on Alexion treatment
This study is a registry, meaning it collects health and disease information from people with generalized myasthenia gravis (gMG) who are receiving Alexion C5 “inhibition” therapies. Your data can help researchers better understand real-world outcomes and disease patterns over time.
Birmingham, AlabamaAges 18 years+ - NCT04097561RecruitingPhase 1
Belimumab safety study for low CD4 counts and autoantibodies
This Phase 1 study tests how safe belimumab is for people with idiopathic CD4 lymphopenia (low protective white blood cells) and signs of autoantibodies. It aims to learn whether the treatment is tolerable and could be a future option for people with this immune condition.
Bethesda, MarylandAges 18–70 - NCT04052022Recruiting
Study of TB flare-ups in people without HIV
This study looks at why some people with tuberculosis (TB) get worse or develop new inflammation after they initially start improving on treatment—called a “paradoxical reaction.” It collects blood and tissue samples to better understand these flare-ups and guide future care.
Bethesda, MarylandAges 18–99
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,067 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,241 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.