Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,069 recruiting studies in this area right now.
By phase
- Not applicable3,003
- Phase 21,060
- Phase 1795
- Phase 1/Phase 2443
- Phase 3437
- Phase 4232
- Phase 2/Phase 399
Top conditions
- Multiple Sclerosis331
- Multiple Myeloma329
- Asthma194
- Lymphoma179
- Type 1 Diabetes132
- Rheumatoid Arthritis131
- Atopic Dermatitis121
- Systemic Lupus Erythematosus120
- Acute Lymphoblastic Leukemia118
- HIV Infections105
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases79
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Hodgkin Lymphoma64
- Diabetes Mellitus, Type 163
- Leukemia63
- Mantle Cell Lymphoma63
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- City of Hope Medical Center50
- Mayo Clinic50
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California498
- Maryland198
- Alabama178
- Florida152
- Arizona150
- Massachusetts116
- New York115
- Texas112
- Illinois86
- Colorado81
Recruiting studies6,069 total
- NCT00923442Enrolling by invitation
Study of blood cancers’ biology using stored or new tissue
This trial studies how different blood cancers and early (pre-cancer) blood conditions work, using tumor/blood tissue samples. It may help researchers learn more about disease biology for future treatments, with little to no extra risk if samples come from routine care.
Bethesda, MarylandAges 1–120 - NCT00789009Recruiting
Monitoring people with known or suspected HIV infection
This study tests how well researchers can track HIV-related health and immune changes over time by collecting blood and other samples. It may help you and your care team by creating detailed monitoring, even if your HIV diagnosis is new or still being evaluated.
Bethesda, MarylandAges 18 years+ - NCT00867269Recruiting
Study of causes and progression of low CD4 blood cells
This study looks for what causes and how idiopathic low CD4 cells happen over time, using blood and tissue samples. It may help doctors learn why this occurs and how to better track people with it.
Bethesda, MarylandAges 18 years+ - NCT00001244Recruiting
Studying Immune System Disorders and Family Genetics
This research study examines how the immune system malfunctions in patients with common variable immunodeficiency (CVID)—a condition where the body doesn't make enough antibodies to fight infections. Researchers want to understand the genetics and immune patterns to help develop better treatments. Family members may also be asked to participate to help identify genetic causes.
Bethesda, MarylandAges 2–120 - NCT00794352Recruiting
Studying immune brain and nerve conditions with tests and samples
This study looks at how immune-related brain or spinal cord illness shows up using exams, MRI scans, and sometimes a spinal fluid test (lumbar puncture), plus collected blood and other samples. It may help researchers better understand these conditions and improve future diagnosis or treatments.
Bethesda, MarylandAges 1 month–99 years - NCT00039689Recruiting
Blood collection study for newly diagnosed HIV research
This research study collects blood cells from people recently diagnosed with HIV who haven't started HIV medicines yet. Researchers use these samples to understand how HIV affects the immune system and develop better treatments.
Bethesda, MarylandAges 18–120 - NCT00106925Recruiting
Long-term follow-up for people after stem cell transplant
This study follows people who are at least 3 years out from their first stem cell transplant to learn how they are doing long term. It may help improve future transplant care by tracking outcomes over time.
Bethesda, MarylandAges 7–80 - NCT00895271Enrolling by invitation
Making lab cell lines from skin biopsies in immune disorders
This study creates special lab cell lines from skin (or nasal) samples from people with immune system disorders and certain family members. It’s meant to help researchers build tools to better study these conditions using patient cells.
Bethesda, MarylandAges 2–85 - NCT01276470Recruiting
Study of environmental triggers in anti-synthetase syndrome
This study looks for environmental risk factors that may be linked to anti-synthetase syndrome, a type of inflammatory muscle disease. It compares people with the condition to carefully matched people without it, using questionnaires, blood samples, and lung imaging when needed.
Miami, FloridaAges 2–100 - NCT00092235Recruiting
Understanding chronic graft-versus-host disease outcomes
This study follows patients who have had a stem cell transplant and developed chronic graft-versus-host disease (a condition where transplanted cells attack the body). Researchers will track your symptoms and collect blood samples to understand what affects how well patients do over time.
Bethesda, MarylandAges 1–120 - NCT01186913Enrolling by invitation
Natural history study for severe combined immune deficiency (SCID)
This study follows children and adults with SCID and related immune disorders to understand how the illness behaves over time. It also helps researchers learn which testing results and genetic types of SCID match different treatment plans.
Birmingham, AlabamaAges Any age - NCT00128973Recruiting
Study immune system problems in people with unusual infections
This study looks at how the immune system works in people who have abnormal immune function, often shown by unusual or repeated infections or long-lasting inflammation. It may involve tests using blood samples and storage of blood for future research.
Bethesda, MarylandAges Any age - NCT00001532Recruiting
How Genes Affect Lung Disease Development
This research study examines how genetic factors contribute to various lung diseases, including alpha-1 antitrypsin deficiency, cystic fibrosis, and chronic obstructive pulmonary disease. Researchers want to understand why some people develop lung disease and how genetics plays a role, which may help improve treatment in the future.
Bethesda, MarylandAges 2–90 - NCT01087333Recruiting
Share blood samples to help study blood cancers and treatments
This study collects human samples (like blood or other specimens) to learn more about hairy cell leukemia and other leukemias. It also helps researchers develop new lab-made immune-based medicines for cancer treatment.
Bethesda, MarylandAges 18 years+ - NCT01212055Recruiting
Apheresis for certain immune system gene problems
This trial studies whether an apheresis procedure (removing blood cells through a machine) can help people with specific inherited immune system conditions. Participants will also receive filgrastim to help move certain blood-forming cells for collection.
Bethesda, MarylandAges 18–40 - NCT01143480Recruiting
Testing how the body responds to endotoxin
This study checks how your immune system (your body’s defense system) reacts to a controlled substance that triggers inflammation. It may help researchers understand why some people have stronger or weaker inflammatory responses.
Research Triangle Park, North CarolinaAges 18–100 - NCT01222741Recruiting
Study of people with higher risk of fungal infections
This study looks at immune system differences that can make some people get unusual or frequent fungal (fungus) infections. It may help researchers better understand these conditions, and you may be asked to store blood for future research.
Bethesda, MarylandAges 18–85 - NCT00001529Recruiting
Bone marrow cell selection method study for transplants
This study tests improved ways to select and collect bone marrow cells from healthy donors for use in transplants. Researchers are looking for healthy volunteers to donate cells that may help people who need bone marrow transplants.
Bethesda, MarylandAges 18–60 - NCT00001406Recruiting
Understanding eosinophil behavior in rare blood and tissue conditions
This research study examines how eosinophils (a type of white blood cell) behave and function when they become abnormally high in the blood or tissues. Researchers want to understand these conditions better to potentially improve treatment options.
Bethesda, MarylandAges 1–100 - NCT00032513Recruiting
Genetic study of chronic active Epstein-Barr virus disease
This research study looks for genetic factors that may explain why some people develop severe, long-lasting Epstein-Barr virus (EBV) infection. Researchers will study blood and tissue samples from patients with this rare condition, their healthy relatives, and unrelated volunteers to understand the disease better.
Bethesda, MarylandAges 1–120 - NCT00246857Recruiting
Screening study for inherited immune system conditions
This study screens people who may have an inherited immune system condition (like problems with immune cell growth or death) and their blood relatives. The goal is to understand the condition better by collecting blood samples for testing.
Bethesda, MarylandAges 1 month–100 years - NCT00404560Recruiting
Blood tests to study infection risk and immune problems
This study looks at how the immune system works in people who have—or might have—an increased risk of infections. It also enrolls their healthy blood relatives so researchers can compare immune features; results may help doctors understand who is at higher risk and why.
Bethesda, MarylandAges 1 month–100 years - NCT00001281Recruiting
Understanding how HIV affects blood cells and body fluids
This research study examines how HIV works in the blood and body fluids of people with and without HIV. By studying blood samples, researchers hope to better understand HIV infection and develop better treatments.
Washington D.C., District of ColumbiaAges 18–120 - NCT00605878Recruiting
Skin microbiome study in healthy people and eczema patients
This study looks at the types of germs on the skin (skin microbiome) in healthy people and people with skin conditions, including atopic dermatitis (eczema). Researchers collect skin samples to understand how skin germs differ and how that may relate to skin health.
Bethesda, MarylandAges 2–100
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,069 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,273 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.