Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07501585Recruiting
Hyaluronic acid gel for infected back tooth surgery
This trial tests whether putting hyaluronic acid (a natural gel-like substance) into the bone during root-end surgery helps heal infections in first molars (back teeth) that didn't get better after a root canal. It may be a good option if you have a small, stubborn infection and your gums are healthy.
MoscowAges 18 years+ - NCT07499869Recruiting
4D virtual simulator for jaw joint diagnosis
This trial tests a new 4D virtual simulator to help diagnose disc displacement in the jaw joint. If you have been referred for an MRI of your jaw joints, this study may help improve how these problems are detected.
NiceAges 18 years+ - NCT07499596Recruiting
Black Mulberry Mouthwash for Gum Inflammation
This trial tests whether a mouthwash made from black mulberry (Morus nigra) can help treat gingivitis (gum inflammation). If you have gum disease but not advanced gum disease, you may be able to join for about 2 weeks of using the mouthwash along with regular brushing.
Battalgazi, MalatyaAges 18–65 - NCT07506018Recruiting
MucoLock for mouth pain caused by stomatitis
This study tests a new mouth rinse, MucoLock, to see if it can help people with severe mouth pain (stomatitis). If you have burning or painful mouth sores that rate very high on a pain scale, this trial may offer a new treatment option.
Miami, FloridaAges 18 years+ - NCT07504614Enrolling by invitation
Comparing two types of tooth sealants for kids with MIH
This study tests whether a new pre-etched bioactive sealant works better than a standard resin-based one to protect permanent molars affected by molar incisor hypomineralization (MIH), a condition that makes teeth softer and more prone to cavities. It aims to find a more effective way to prevent decay in these vulnerable teeth.
IrbidAges 6–12 - NCT07505485Recruiting
AI for diagnosing jawbone lesions
This trial uses artificial intelligence to better analyze bone lesions or cysts in the jaw. It aims to see if a computer can help dentists make more accurate diagnoses and treatment plans.
BariAges 18–80 - NCT07502651Enrolling by invitationEarly Phase 1
Comparing two sedatives for jaw fracture surgery
This trial tests two medications given as a nasal spray to help you relax during surgery for a broken jaw. The goal is to see which one works better and is safer.
Rohtak, HaryanaAges 18–50 - NCT06762821Recruiting
Single vs multiple visit root canal for immature teeth
This study compares doing root canal treatment in one visit versus multiple visits for children with an immature front tooth that has died (the nerve is damaged). It aims to see which approach helps the tooth heal better over 24 months.
MinyaAges 7–13 - NCT06657690RecruitingPhase 2
New drug combo for advanced nasopharyngeal cancer after immunotherapy
This trial tests a combination of two drugs, irinotecan liposome and S-1, for people with a type of nose and throat cancer that has spread or come back after treatment with immunotherapy (PD-1/L1 inhibitors). The goal is to see if this new combination can help when standard treatments have stopped working.
Zhuhai, GuangzhouAges 18–70 - NCT07491536Recruiting
Ozone therapy for mouth sores from cancer treatment
This trial tests if adding ozone therapy to a special mouthwash routine can help heal painful mouth sores caused by chemotherapy or radiation. It is for cancer patients with mild to moderate oral mucositis.
Pavia, LombardyAges 18 years+ - NCT07492576Recruiting
Magnesium shield vs. standard graft for implants
This trial compares two methods for placing dental implants right after removing a failing tooth in the upper front area. It tests whether a magnesium shield helps preserve the bone and gum better than the usual grafting technique.
CairoAges 18–60 - NCT07493941Enrolling by invitation
Bleaching teeth with different light methods
This study compares different ways of activating a teeth-whitening gel to see which works best, feels best, and causes the least tooth pain. If you want whiter teeth and are in good oral health, this may be for you.
Tanta, TantaAges 20–35 - NCT07491809Recruiting
Aesthetic dental veneers study with adhesive cementation
This trial tests different materials and methods for cementing veneers. It may help if you have healthy gums and need at least 4 veneers.
RigaAges Any age - NCT07497568Recruiting
Metformin gel for dental implant stability
This study tests whether applying a metformin gel to the implant site can help the implant stay stable and improve bone density around it. It may be a good option if you need a dental implant and have healthy enough jawbone.
Baghdad, Baghdad GovernorateAges 18–70 - NCT07491848Recruiting
Mouth health study for hepatitis B and D patients
This study looks at mouth health in people with hepatitis B and D, including those taking a medicine called bulevirtide and those not taking it. It may help understand how these infections affect the mouth and gums.
CraiovaAges 18 years+ - NCT07491627Enrolling by invitation
Nicotine's effect on gum disease treatment in smokers and non-smokers
This study looks at how smoking and nicotine affect the success of gum disease treatment. It compares results between smokers and non-smokers who have gum disease.
Liège, LiegeAges 18 years+ - NCT07498361Recruiting
Comparing absorbable stitches in wisdom tooth removal
This trial compares two types of dissolving stitches (sutures) used after wisdom tooth surgery to see which works better. It may help your mouth heal faster with fewer problems.
Padua, PaduaAges 18 years+ - NCT07496164Recruiting
Testing three new denture adhesives against no adhesive
This study tests whether three new denture adhesives help people who have a full upper denture (false teeth on the top) and some natural or false teeth on the bottom. You will try each adhesive and also a period with no adhesive to see how well your denture stays in place.
Indianapolis, IndianaAges 18 years+ - NCT07494747Recruiting
Toothpaste for sensitive gums
This trial tests a toothpaste for people with sensitive, inflamed gums (gingivitis). It looks at how well the toothpaste reduces gum bleeding and plaque.
Castelldefels, BarcelonaAges 18–65 - NCT06381713Recruiting
Speech therapy for children with cleft palate
This study compares two types of speech therapy for children with cleft palate. It looks at how well each type works and how much it costs, to help find the best way to improve your child's speech.
GhentAges 4–12 - NCT06472713RecruitingPhase 2
Liposomal mitoxantrone with immunotherapy for advanced nasopharyngeal cancer
This trial tests a combination of a chemotherapy drug (mitoxantrone liposome) with an immunotherapy (PD-1 blocker) for people whose nasopharyngeal cancer has come back or spread and hasn't responded to previous treatments. The goal is to see if this combination can shrink tumors or slow cancer growth.
Zhuhai, GuangdongAges 18–70 - NCT06505759RecruitingPhase 1
Bromelain gel vs. chlorhexidine for gum disease treatment
This trial tests if a gel made from bromelain (a pineapple enzyme) works as well as a standard antibiotic gel to treat gum pockets caused by periodontitis. It may offer a gentler option for patients with moderate gum disease.
Bengaluru, KarnatakaAges 30–50 - NCT06772051Recruiting
Testing a shorter etching time for cavities
This study is testing if a shorter acid etching time works just as well for filling cavities in children's or adults' back teeth. It may help make the filling process quicker and more comfortable.
Al Mansurah, DakahliyaAges 35–50 - NCT06349889RecruitingPhase 2
Adebrelimab with chemo and radiation for high-risk nasopharyngeal cancer
This trial tests adding the immunotherapy drug adebrelimab to standard chemotherapy and radiation for people with a high-risk type of nasopharyngeal cancer (stage IVA). The goal is to see if this combination helps control the cancer better.
Xiamen, FujianAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.