Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07522671Recruiting
3D-Printed Crowns and Bridges for Dental Implants
This trial compares two types of artificial tooth restorations (made from resin or zirconia) placed on dental implants that have already fused with your jawbone. The study tests how well these 3D-printed restorations work and last over time.
Shibīn al KawmAges 18–60 - NCT07524569Recruiting
Digital vs. manual anesthesia in children's dental care
This study compares two ways of numbing teeth (digital intraosseous and manual intraligamentary anesthesia) in children who need fillings on back molars. It aims to see which method works better and causes less discomfort.
Izmir, CigliAges 6–12 - NCT07523815RecruitingPhase 4
AI-Assisted versus Standard Planning for Dental Implants
This study compares using artificial intelligence computer planning versus standard planning methods for placing a single dental implant in your back teeth. The goal is to see if AI planning makes the implant placement faster, easier, and more precise.
Cairo, ManialAges 18–50 - NCT07522684Recruiting
Gel treatment for deep gum bone loss around teeth
This trial tests a special gel made with growth-promoting compounds and animal-derived material to help repair deep bone loss in the gums around teeth. It may help restore bone that periodontitis (advanced gum disease) has damaged.
Ribeirão Preto, São PauloAges 18 years+ - NCT07508839Recruiting
Probiotic lozenge study for healthy adults
This trial tests a probiotic lozenge (a dissolvable tablet) to see if it's safe and works well. It's for healthy adults who don't smoke and are between 18 and 70 years old.
Hamilton, OntarioAges 18–70 - NCT06759896Recruiting
Facemask vs braces for underbite in growing children
This trial compares a facemask device with upper braces to correct underbite in children ages 7–10. It aims to find which treatment works better to align the jaw and teeth.
Kuala Lumpur, Kuala LumpurAges 7–10 - NCT07514208Enrolling by invitation
Headache Sensitivity and Pain Testing Study
This study examines how sensitive the skin and tissues around the head are in people with migraines or tension headaches. Researchers will perform gentle touch and pressure tests to understand pain patterns, which may help improve headache treatment in the future.
Barcelona, BarcelonaAges 18 years+ - NCT07514585Enrolling by invitation
Testing new dental implant impression tools
This study tests a new type of dental tool (called a bionic healing abutment) used when taking impressions for dental implants. Researchers want to see if this tool makes the implant process easier and more accurate for patients with missing teeth.
Fuzhou, FujianAges 18–65 - NCT07509281Recruiting
How implant parts affect healing and gum health
This trial compares different shapes and heights of the abutment (the connector piece between the implant and crown) to see how they affect gum and bone healing. It is for people who need a single or few back teeth replaced with a dental implant.
Valencia, ValenciaAges 18 years+ - NCT07507864Recruiting
Testing a Turkish Oral Health Assessment Tool
This study tests a Turkish-language tool that helps nurses check the mouth health of older adults. It aims to see if the tool works well for people aged 60 and older who can understand Turkish.
Konya, KonyaAges 60 years+ - NCT07515937Recruiting
3D-Printed Bite Splint for Broken Jaws in Children
This study tests a custom 3D-printed bite splint to help heal straightforward jaw fractures in children aged 6–12. Instead of surgery, the splint guides the broken pieces back together while your child heals naturally.
Cairo, Cairo GovernorateAges 6–12 - NCT07507734Recruiting
Splint and exercise therapy for jaw joint pain
This trial tests whether a custom mouth splint combined with jaw exercises can reduce pain in the jaw joint (TMJ). It may help people who have had jaw joint pain for at least 3 months.
Istanbul, TuzlaAges 18–65 - NCT07511959Enrolling by invitation
Blood-derived treatment for chronic jaw pain
This trial tests whether a treatment made from your own blood (platelet-rich plasma exosomes) can help relieve long-term jaw joint pain and improve function. If you qualify, you would receive injections directly into your jaw area.
WroclawAges 18 years+ - NCT07509476Recruiting
Bone changes after immediate front tooth implant
This study looks at how the bone on the front of your upper jaw changes when a dental implant is placed right after removing a tooth that can't be saved. It may help people who need a front tooth replacement and have enough bone thickness.
CairoAges 21 years+ - NCT07507474Recruiting
New treatment for gum disease (Bioperio protocol)
This trial tests a treatment called Bioperio for people with gum disease (periodontitis) who have not been treated before. It looks at how well the treatment works over time.
Pisa, None SelectedAges 18 years+ - NCT07513727Recruiting
Vitamin C Treatment for Dark Gum Pigmentation
This study tests whether vitamin C can safely lighten dark spots or patches on your gums that are caused by natural pigmentation. If you're bothered by how these dark areas look, this trial may help improve your smile's appearance.
Cairo, Cario GovernorateAges 20–40 - NCT07508033RecruitingPhase 1/Phase 2
Stem cell exosomes vs platelet-rich fibrin for socket healing
This trial tests whether stem cell exosomes (tiny healing particles from stem cells) work better than platelet-rich fibrin (a blood-derived clot) to help a tooth socket heal after extraction. It may help if you need a single front or premolar tooth removed and are generally healthy.
Tanta, Gharbia GovernorateAges 20–45 - NCT07513792Recruiting
3D imaging to prevent gum shrinkage during clear aligner treatment
This study tests whether a special 3D imaging tool helps protect your gums from pulling back (receding) while straightening your teeth with clear aligners. Gum recession can expose tooth roots and cause sensitivity, so the trial is exploring whether better visualization during treatment planning prevents this problem.
Liège, LiegeAges 18 years+ - NCT07509619Recruiting
AI physiotherapy evaluation for oral cancer patients
This study is testing a new AI-based system that helps evaluate mouth and jaw movement (range of motion) in oral cancer patients. It enrolls healthy volunteers without any head or neck problems to gather normal movement data.
TaipeiAges 20–70 - NCT06760884Recruiting
Pregnancy and jaw function study
This study looks at jaw joint function, oral habits, and pain in pregnant and non-pregnant women. It aims to understand how pregnancy might affect these issues.
TrabzonAges 18–45 - NCT07501455Recruiting
Studying toothpaste and mouth rinse effects on gum inflammation
This study tests whether using a certain toothpaste and mouth rinse can reduce gum inflammation (gingivitis) better than brushing alone. It is for people with mild to moderate gum disease who have not used tobacco or certain medications recently.
Somerville, MassachusettsAges 18–60 - NCT06643663Recruiting
Gum surgery for teeth with gum disease and failed root canal
This study tests a gum surgery technique (guided tissue regeneration) to help heal teeth that have both gum disease and a failed root canal. It looks at how well the tooth heals and how it affects your daily life.
HaryānaAges 16 years+ - NCT06763419Recruiting
Light therapy for jaw joint pain
This trial tests if a non-invasive light therapy (photobiomodulation) can reduce pain and clicking in the jaw joint. It may help people with jaw pain caused by muscle tension or joint issues.
AlexandriaAges 20–40 - NCT07505485Recruiting
AI for diagnosing jawbone lesions
This trial uses artificial intelligence to better analyze bone lesions or cysts in the jaw. It aims to see if a computer can help dentists make more accurate diagnoses and treatment plans.
BariAges 18–80
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.