Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT07256561Recruiting
Testing simvastatin gel inside root canals for infection and pain
This study tests whether a gel containing simvastatin, a medicine usually used for cholesterol, can help fight infection and reduce inflammation inside a tooth's root canal. It might be a treatment option for people who have a failed root canal and still have a small infection at the tip of the tooth root.
CairoAges 20–40 - NCT07251543Enrolling by invitation
Salivary gland massage for dry mouth in older adults
This study tests whether a simple salivary gland massage program can help older adults with dry mouth improve chewing, swallowing, and overall oral health. It's designed for people aged 65 and older who can follow instructions and participate in activities.
Chiayi City, TaiwanAges 65 years+ - NCT07239024Enrolling by invitationPhase 1
Comparing two ways to speed up canine tooth movement
This study compares two methods to speed up moving your canine teeth into their correct position after removing the premolars: a small surgical procedure (piezocision) or a natural blood concentrate treatment (injectable platelet-rich fibrin). The goal is to see which method works better for faster, safer tooth movement.
CairoAges 14–22 - NCT07234552Recruiting
Effect of implant screw tightness on bone loss
This trial looks at how tightly the screw that holds a dental implant crown is tightened and whether that affects bone loss around the implant over time. It may help find the best way to tighten screws to keep your implant healthy.
Valencia, ValenciaAges 18 years+ - NCT07104370Recruiting
Comparing freeze-dried donor bone vs. your own bone for jaw grafting
This trial compares two types of bone graft materials for rebuilding the jawbone so you can later get dental implants. One is a freeze-dried bone from a donor (allograft), and the other is a small piece of your own bone (autograft).
Budapest, HungaryAges 18 years+ - NCT07141459Recruiting
Laser disinfection for failed root canal treatment
This trial tests if using a special laser (810 nm diode) to disinfect the tooth after a second root canal treatment can reduce pain and inflammation. It aims to help patients whose previous root canal failed and who have a small infection around the tooth root.
CairoAges 20–40 - NCT07156695Recruiting
Deep filling study for tooth decay and gum health
This trial tests a technique called deep marginal elevation for fixing deep cavities near the gumline. It aims to see if this method affects your gum health compared to a healthy tooth on the other side.
Tanta, El-GharbiaAges 18–60 - NCT07179510Recruiting
Study of a new dental bone filler for surgery patients
This study follows patients who receive a new injectable bone filler called Neocement® Inject P during dental reconstructive surgery. The goal is to see if it is safe and works well to help heal bone defects.
LisbonAges 18 years+ - NCT07177495Recruiting
Bone graft mix for sinus lift in upper jaw
This trial tests a bone graft made of your own bone mixed with cow bone (Deproteinized Bovine Bone) to rebuild the upper jaw in the sinus area. It compares this mixed bone graft to using only cow bone for a sinus lift, helping you get implants when there is not enough bone height.
Cairo, Giza GovernorateAges 30 years+ - NCT07153861Recruiting
Mouth tissue vs lip tissue for female urethral repair
This trial compares using a graft from the mouth or lip to treat a narrowed urethra in women. It aims to find which approach works better for improving urinary flow.
Tanta, El-GharbiaAges 18 years+ - NCT07124416Recruiting
Do gums around dental implants affect health and comfort?
This study looks at how the amount of firm, attached gum (called keratinized mucosa) around a dental implant affects gum health and how you feel about it. It may help you understand if your implant site needs more gum tissue for better long-term results.
Hangzhou, ZhejiangAges 18–90 - NCT07179497Recruiting
Study of Neobone in dental bone surgery
This study looks at how safe and effective Neobone is for repairing bone in dental surgery. If you need a bone graft for your jaw or teeth, this could be relevant.
LisbonAges 18 years+ - NCT07078890Recruiting
Bone graft with implant removal for better reimplant success
This study tests whether adding a bone graft at the same time a failed dental implant is removed helps the new implant placed later in the same spot heal better. It may be a good option if you need a failed implant replaced and want to improve bone support for the new one.
Wuhan, HubeiAges 18–90 - NCT07063836Recruiting
Managing multiple adjacent tooth sockets
This trial tests a way to place dental implants right after removing several failing teeth at once in the front of the mouth. It may help if you need to replace two or more teeth that cannot be saved.
CairoAges 18–70 - NCT07051057Enrolling by invitation
Oral health and diet of Sinai U students
This study looks at the oral hygiene and eating habits of physical therapy and pharmacy students at Sinai University. It aims to understand how these habits affect their health, which may help improve student wellness programs.
Ismailia, EgyptAges 16–25 - NCT06254911RecruitingPhase 2
Immunotherapy before surgery for HPV-related throat cancer
This trial tests whether giving the drug atezolizumab before surgery can help shrink HPV-related throat cancer and improve outcomes. Atezolizumab helps your immune system fight cancer cells.
Atlanta, GeorgiaAges 18 years+ - NCT06892496Recruiting
Healing after palate graft: comparing protection methods
This trial compares different ways to protect the roof of your mouth after a small tissue graft is taken to cover exposed roots or gum recession. It aims to find which method reduces pain and helps healing.
Richmond, VirginiaAges 18 years+ - NCT05720065RecruitingPhase 2
Testing botulinum toxin A for jaw muscle pain
This trial studies whether botulinum toxin A (a type of muscle-relaxing medicine) can reduce jaw muscle pain and help explain why it happens. It focuses on people with specific jaw muscle pain patterns and tests outcomes after injection/biopsy.
Huddinge, Stockholm CountyAges 20–45 - NCT07156227RecruitingPhase 1
Testing camonsertib with radiation for returning head and neck cancer
This study tests whether adding the drug camonsertib to radiation therapy can help people whose head and neck cancer has come back in a spot that was already treated with radiation. Camonsertib is an experimental drug that may help radiation work better.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07717307Recruiting
Comparing two neck surgeries for oral cancer spread
This trial tests whether a smaller neck surgery works as well as a larger one for people with oral cancer that has spread to one lymph node. The goal is to see if less extensive surgery can reduce side effects while still controlling the cancer.
Kolhāpur, MaharashtraAges 21–75 - NCT07738185Recruiting
Massage after tongue-tie surgery in babies
This trial tests whether gentle mouth massages after tongue-tie surgery (frenotomy) can help prevent the tongue from re-attaching and improve feeding in babies under 1 year old.
Boynton Beach, FloridaAges Up to 1 year - NCT07740447Recruiting
Non-surgical gum treatment and its effect on body chemistry
This study looks at whether a standard non-surgical gum disease treatment changes certain chemicals in your blood or saliva. It may help show how treating gum disease can improve your overall health.
Catania, ItalyAges 18–70 - NCT07739732Recruiting
Gum disease mouth fluid study
This study compares the chemicals in the fluid around teeth between people with gum disease and healthy people. The goal is to find changes that could help understand or detect gum disease.
Catania, ItalyAges 18–70 - NCT06982105RecruitingPhase 4
Comparing two antibiotics for children with MRSA bone or head infections
This study compares two oral antibiotics, TMP-SMX and clindamycin, to see which works better for children with MRSA infections in bones, joints, or head/neck areas. It aims to find the best treatment after initial IV therapy.
Indianapolis, IndianaAges 2 months–18 years
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.