Treatment
Dose Escalation clinical trials
We’re tracking 187 recruiting studies that include Dose Escalation, each written for real people, not researchers, below.
Recruiting studies
- NCT04808323RecruitingPhase 1
MRI-guided radiation to help preserve organs in rectal cancer
This Phase 1 study tests a radiation treatment approach guided by MRI scans to help keep nearby organs functioning while treating rectal cancer. It is designed to find a safe, effective way to target the tumor and adjust treatment during the course of therapy.
Milwaukee, WisconsinAges 18 years+ - NCT05348486Recruiting
Adaptive radiation planning using FMISO imaging for head and neck cancer
This trial tests a way to personalize radiation treatment using a special scan (FMISO) to improve targeting in certain head and neck cancers. It is designed for people who are newly diagnosed and ready for standard curative (definitive) chemoradiation or faster radiation schedules.
BrnoAges 18 years+ - NCT05871021RecruitingPhase 2
Bevacizumab plus careful dosing for glioblastoma after surgery
This Phase 2 study tests a protective approach using bevacizumab (a medicine that blocks VEGF) while doctors carefully increase the dose in people with glioblastoma. It’s meant to help control tumor growth and possibly reduce certain risks that can happen with blood-vessel–targeting treatments.
AugsburgAges 18–70 - NCT06185673RecruitingPhase 1/Phase 2
Gene therapy trial for OPMD with swallowing problems
This trial tests an experimental gene therapy (BB-301) for people with OPMD who have trouble swallowing. It involves a one-time injection into the throat muscles during a short surgery, and researchers will check if it is safe and improves swallowing.
New York, New YorkAges Up to 65 years - NCT06993844RecruitingPhase 1/Phase 2
Study of ETX-636 for advanced solid tumors with PIK3CA mutation
This trial tests an experimental drug called ETX-636 in people whose cancer has a specific gene change (PIK3CA mutation) and has not responded to at least one prior treatment. The goal is to see if the drug can shrink tumors or stop them from growing.
Newport Beach, CaliforniaAges 18 years+ - NCT07426094RecruitingPhase 2/Phase 3
Boosting radiation for prostate cancer in lymph nodes
This trial tests whether giving higher radiation doses to the prostate and pelvic lymph nodes is more effective than treating only the prostate. You may benefit if your prostate cancer has spread to nearby lymph nodes but not to bones or other organs, and you are getting hormone therapy.
Zamość, Lublin VoivodeshipAges 18 years+ - NCT06464055RecruitingPhase 1/Phase 2
A study of GQ1010 for advanced solid tumors
This trial tests a new drug called GQ1010 for people with advanced solid tumors that have stopped responding to standard treatments. The drug targets a protein called Trop-2 on cancer cells to try to shrink tumors or slow their growth.
BeijingAges 18 years+ - NCT06830356Recruiting
PET-guided radiation for high-risk meningiomas
This trial uses a special PET scan to find active tumor areas and then delivers a stronger dose of radiation to those spots. It is for people with aggressive or returning meningiomas who have not had brain radiation before.
Aviano, PordenoneAges 16 years+ - NCT05761223RecruitingPhase 1/Phase 2
Study of FB849 for adults with measurable cancer lesions
This early-stage trial tests whether FB849 is safe and tolerable, how the body handles it, and whether it shows any early signs of helping cancer. You may be able to join if you’re an adult with at least one measurable tumor spot and your health tests meet study requirements.
Cleveland, OhioAges 18 years+ - NCT07337876RecruitingPhase 2
Avoiding surgery for rectal cancer with precise radiation
This trial tests a new way to give high-dose radiation to rectal cancer tumors while avoiding the bladder and bowels. The goal is to cure the cancer without removing the rectum, so you may keep normal bowel function.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07391982Recruiting
Short course MRI-guided radiation for prostate cancer
This trial tests a shorter radiation plan using an MRI machine to guide treatment. The goal is to see if two high-dose sessions work just as well as longer treatment, with fewer side effects. It is for men with low or intermediate risk prostate cancer.
AmsterdamAges 18 years+ - NCT06484491Recruiting
Higher-dose proton therapy for stage III lung cancer
This trial tests whether giving a higher dose of a special, precise form of radiation (proton therapy) to the main tumor can improve outcomes for people with stage III lung cancer who are already scheduled for chemoradiation and immunotherapy. It may help by targeting the tumor more effectively while protecting nearby organs.
GroningenAges 18 years+ - NCT06854679Recruiting
MRI-guided radiation for rectal cancer
This trial tests a new way of giving radiation therapy for rectal cancer, using MRI scans to aim the radiation more precisely. It's for people who need chemotherapy and radiation before surgery, and it aims to make treatment more effective while reducing side effects.
Sutton, SurreyAges 18 years+ - NCT07325500RecruitingPhase 2
Low dose GLP-1 for heart health in HIV
This study tests a very low dose of a medication called a GLP-1 receptor agonist to see if it can improve heart and metabolic health in people with HIV who have excess weight.
Houston, TexasAges 18 years+ - NCT06863532Recruiting
Comparing two add-on treatments for type 2 diabetes
This trial compares adding a new pill (cofrogliptin) to increasing your current metformin dose, for people whose blood sugar is still too high despite taking an SGLT2 inhibitor and a low dose of metformin. The goal is to see which option works better and is safer.
Hangzhou, ZhejiangAges 18–74 - NCT04952480RecruitingPhase 2
Adaptive chest radiation for newly diagnosed small cell lung cancer
This study tests a customized (“adaptive”) way to give radiation to the chest for newly diagnosed small cell lung cancer. It aims to improve how well treatment targets the tumor while safely adjusting to tumor changes during therapy.
Edmonton, AlbertaAges 18 years+ - NCT05594368RecruitingPhase 1
Test targeted radiation to treat recurrent ventricular tachycardia
This trial studies a radiation approach (called stereotactic body radiation therapy, or SBRT) to treat ventricular tachycardia (a dangerous heart rhythm) that keeps coming back. It aims to reduce the rhythm episodes in people who have already tried catheter ablation (a procedure to cauterize rhythm sources) or cannot have it.
OstravaAges 18 years+ - NCT06078813RecruitingPhase 1/Phase 2
Higher dose spine radiation for limited spread cancers
This trial tests a higher dose of focused radiation (SABR) for people whose solid cancer has spread to the spine in a few spots. The goal is to control those tumors with fewer side effects.
CorkAges 18 years+ - NCT05780684Recruiting
Personalized 5-FU dosing for advanced gastrointestinal cancer
This study tests whether doctors can safely find the best dose of 5-FU, a chemotherapy medicine, for people with advanced gastrointestinal cancers. The goal is to reduce side effects while still treating the cancer effectively.
Lebanon, New HampshireAges 18 years+ - NCT06446713RecruitingPhase 1
Higher-dose proton therapy for advanced throat cancer
This trial is testing a higher, more precise dose of proton beam radiation for people with advanced throat cancer that is not connected to HPV. It aims to improve tumor control while protecting healthy tissue.
GroningenAges 18 years+ - NCT07189598Recruiting
High-dose radiation therapy for high-risk prostate cancer
This trial tests whether giving a higher dose of radiation therapy (called SBRT) can safely and effectively treat high-risk prostate cancer that hasn't spread. It's for men who have not yet been treated for their cancer.
RennesAges 18 years+ - NCT06792682RecruitingPhase 1
Cord blood cells for poor graft function after transplant
This study tests whether umbilical cord blood cells can help patients whose blood counts have dropped again after a stem cell transplant. It may be an option for people who have recovered initially but later develop low blood cell levels.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07188532Recruiting
Personalized high-dose radiation for Ewing sarcoma
This trial tests a personalized radiation therapy that adjusts the dose based on your tumor. It aims to improve treatment for Ewing sarcoma while limiting side effects.
Phoenix, ArizonaAges 2 years+ - NCT06254690RecruitingPhase 2
Pyrotinib dosing study for HER2-positive advanced breast cancer
This trial tests different doses of pyrotinib, a targeted therapy, for women with HER2-positive advanced breast cancer that has not yet been treated for recurrence. It aims to find the best dosing regimen to control the cancer.
Nanjing, JiangsuAges 18–70
What Dose Escalation is being studied for
Conditions with recruiting Dose Escalation studies.
Common questions
- Are there clinical trials studying Dose Escalation?
- Yes. Clin2 currently lists 187 recruiting studies that include Dose Escalation, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Dose Escalation trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Dose Escalation an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Dose Escalation or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.