Treatment
Dose Escalation clinical trials
We’re tracking 186 recruiting studies that include Dose Escalation, each written for real people, not researchers, below.
Recruiting studies
- NCT06732232RecruitingEarly Phase 1
CAR-T therapy for multiple myeloma that returned or didn't respond
This early trial tests a new CAR-T cell treatment targeting three proteins (CD19, CD22, and BCMA) on myeloma cells. It's for people whose myeloma came back or didn't respond to at least three prior treatments.
ShanghaiAges 18–75 - NCT06765876RecruitingEarly Phase 1
CAR T-cell therapy for CD123+ blood cancers
This trial tests a new type of immunotherapy called CAR T-cells that target a protein called CD123 on cancer cells. It is for people with certain blood cancers (AML, MDS-IB2, BPDCN, or ALL) that have come back or not responded to other treatments.
PragueAges 18–70 - NCT06769490RecruitingPhase 1
Ziftomenib and Quizartinib combination for AML
This trial tests two targeted drugs, ziftomenib and quizartinib, together for people with a certain type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The goal is to find the best dose and see if the combination helps.
Houston, TexasAges 18 years+ - NCT06770764RecruitingPhase 1
Testing ODC-IL2 for advanced solid tumors
This trial tests a new drug called ODC-IL2 for people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to help your immune system fight cancer. The study starts with small doses to find the best dose, then expands to see how well it works.
Scottsdale, ArizonaAges 18 years+ - NCT06794125Recruiting
Higher radiation dose for chest tumors
This trial tests if giving a higher dose of radiation to tumors in the chest (lungs or nearby areas) can better control symptoms or prevent them from getting worse. It is for people who need palliative radiation—treatment aimed at easing discomfort or slowing tumor growth, not curing the cancer.
Kelowna, British ColumbiaAges 18 years+ - NCT06835803RecruitingPhase 2
Intensified radiation for older adults with glioblastoma
This trial tests whether a more focused, stronger dose of radiation can improve outcomes for people 65 and older with newly diagnosed glioblastoma. It compares this approach to standard radiation to see if it's safe and effective.
Boston, MassachusettsAges 65 years+ - NCT06846905Recruiting
Cost and effects of raising the dose of myeloma drugs at home vs. hospital
This study compares whether raising the dose of your current bispecific antibody is more cost-effective when done as an outpatient (day hospital) or as an inpatient. It aims to find the best way to manage your treatment safely.
ToulouseAges 18 years+ - NCT06980025RecruitingPhase 3
Aspirin dose trial to prevent preterm birth
This study tests if a higher dose of aspirin can help prevent another early delivery in women who have had a preterm birth before. If you qualify, you would take either a standard or escalated dose of aspirin during your current pregnancy.
Birmingham, AlabamaAges 14 years+ - NCT07015892RecruitingPhase 3
Higher radiation dose for limited-stage small cell lung cancer
This trial tests a higher dose of radiation therapy for people with limited-stage small cell lung cancer (cancer that hasn't spread beyond the chest). It aims to see if the higher dose works better than the standard dose at controlling the cancer.
Salamanca, SalamancaAges 18 years+ - NCT07021846Recruiting
Higher-dose radiation for early breast cancer in young women
This study tests a higher-dose, faster radiation treatment for young women with early breast cancer who have certain risk factors. The goal is to reduce the chance of cancer coming back while keeping side effects low.
RomaAges 18–50 - NCT07051629RecruitingPhase 1
Testing a new epilepsy medicine for safety in healthy people and patients
This study tests a new medicine called SIF001 for safety. It first gives the medicine to healthy volunteers, and then to people with epilepsy who have seizures even while on their current medicines. The goal is to find a safe dose.
Tucson, ArizonaAges 18–70 - NCT07118085RecruitingPhase 1
Testing the safety of IMC-003 in healthy postmenopausal women
This study tests the safety of a new medicine called IMC-003. It is for healthy women who have gone through menopause. You may be able to join if you are between 45 and 75 years old and meet certain health criteria.
Chengdu, SichuanAges 45–75 - NCT07173972RecruitingPhase 2
Proton radiation for inoperable soft tissue sarcoma
This trial studies a high-dose, shortened course of proton beam radiation for people with soft tissue sarcoma that cannot be removed by surgery. It aims to improve tumor control while reducing side effects.
BergenAges 18 years+ - NCT07205926RecruitingPhase 1
Testing a new Shigella vaccine in healthy adults
This trial tests a new Shigella vaccine in healthy adults to see if it is safe and creates a good immune response. It is a first-in-human study, meaning this is the first time the vaccine is given to people.
Cincinnati, OhioAges 18–49 - NCT02390518RecruitingPhase 1
Tested different radiation doses for brain metastases
This Phase 1 study tests how to safely give focused radiation (SRS) at different doses to people with brain metastases. It aims to find a dose level that works well while limiting side effects.
Salt Lake City, UtahAges 18 years+ - NCT07342114RecruitingPhase 1
Safety study of new drug RO7875913 in healthy adults
This early-phase trial tests a new drug called RO7875913 in healthy volunteers to find the safest dose. It helps researchers understand how the drug works in the body before moving to studies in people with the disease.
Christchurch, CanterburyAges 18–65 - NCT07359417RecruitingPhase 1
MR-guided radiation boost for esophageal cancer
This trial tests whether giving a higher dose of radiation to the main tumor, guided by MRI scans, can improve treatment for a type of esophageal cancer called squamous cell carcinoma. You would first receive standard chemoradiation followed by surgery.
Utrecht, UtrechtAges 18 years+ - NCT01853631RecruitingPhase 1
CAR T-cell therapy for CD19-positive B-cell blood cancers
This Phase 1 study tests a personalized form of immune therapy called CAR T cells that are designed to recognize CD19, a marker on certain B-cell cancers. It may help people with difficult-to-treat (recurrent or relapsed) B-cell lymphoma or leukemia (ALL/CLL).
Houston, TexasAges Up to 75 years - NCT02870244RecruitingPhase 1
Engineered T-cell therapy for advanced melanoma patients
This Phase 1 study tests a lab-made immune cell treatment for advanced melanoma. It aims to see if engineered T-cells can recognize the patient’s tumor and help control the cancer, especially in specific melanoma tissue markers.
Maywood, IllinoisAges 18–89 - NCT07425821RecruitingPhase 1
Marburg Virus Vaccine Safety Trial
This trial tests a new vaccine to protect against Marburg virus, a rare but serious infection. The vaccine uses a weakened virus to teach your body to fight the Marburg virus, and researchers are checking if it is safe and how well it works.
Washington D.C., District of ColumbiaAges 18–50 - NCT07437105RecruitingPhase 1
Healthy volunteer study of VX-272 safety
This study tests a new investigational medicine called VX-272 in healthy volunteers. Researchers want to check its safety and how it moves through the body, so you would not have the condition the medicine is being developed for.
Tempe, ArizonaAges 18–55 - NCT07439887RecruitingPhase 1/Phase 2
Study of an injection for Stargardt disease
This trial tests a single injection of a new medicine, RTx-021, into the eye for people with Stargardt disease. The goal is to see if it is safe and to find the right dose.
Bakersfield, CaliforniaAges 16 years+ - NCT07458347RecruitingPhase 1
A new oral drug for KRAS-mutated advanced cancer
This trial tests a new oral drug, KST-6051, for people with advanced solid tumors (like lung, pancreatic, colon, or other cancers) that have a specific KRAS gene mutation. The goal is to find the best dose and see if it's safe.
Los Angeles, CaliforniaAges 18 years+ - NCT07563452Recruiting
How Exercise Affects Muscles in People Taking Cholesterol Medicine
This study compares how muscles recover after exercise in people who take statin medications (cholesterol-lowering drugs) versus those who don't. Researchers want to understand if statins affect how well muscles bounce back from physical activity.
Innsbruck, TyrolAges 30–65
Common questions
- Are there clinical trials studying Dose Escalation?
- Yes. Clin2 currently lists 186 recruiting studies that include Dose Escalation, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Dose Escalation trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Dose Escalation an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Dose Escalation or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.