Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,015 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05700721RecruitingPhase 2
Niraparib and dostarlimab for cancer with growing brain spots
This trial studies whether the medicines niraparib and dostarlimab can slow advanced cancers that have active, growing brain metastases. It is meant for people whose brain tumors can be measured on MRI and who have had at least one previous treatment.
Houston, TexasAges 18 years+ - NCT05647044RecruitingPhase 1
Brain stimulation to reduce impulsivity and suicidal thoughts after mild TBI
This early-stage study tests whether a noninvasive brain stimulation treatment (called iTBS) can reduce impulsivity and suicidal thoughts in Veterans who have had a mild traumatic brain injury (mTBI) and recent suicidal thinking. If you qualify, you may be offered a monitored treatment plan and assessments for safety and symptom changes.
Hines, IllinoisAges 22–65 - NCT05658731Recruiting
Radiation planning study to protect thinking in children
This study compares how radiation is planned to see whether it better protects thinking and memory in children and young adults. It may help future patients by learning which planning approach leads to better cognitive (thinking) outcomes.
Washington D.C., District of ColumbiaAges 1–26 - NCT05673928RecruitingPhase 2
Tucatinib and T-DM1 for HER2-positive brain-metastasis tumors
This Phase 2 study tests tucatinib plus T-DM1 (ado-trastuzumab emtansine) in people with HER2-positive metastatic solid tumors that have spread to the brain. It aims to shrink brain and body tumors and help control cancer that is progressing in the brain.
Houston, TexasAges 18 years+ - NCT05609123Recruiting
Study of blood-surface damage in brain-dead organ donors
This study looks at damage to a protective layer on blood vessels in people who have been declared brain dead. The goal is to better understand what happens in brain-dead donors, which could help improve organ donation care and outcomes.
Hradec KrálovéAges 18 years+ - NCT05616910Enrolling by invitationPhase 2
Inhaled nitric oxide for microvascular problems after brain injury
This Phase 2 study tests whether inhaled nitric oxide can improve tiny blood-flow problems in the brain after traumatic brain injury. If you qualify, you may receive inhaled nitric oxide and be monitored for safety and recovery.
Philadelphia, PennsylvaniaAges 18–75 - NCT02793999Recruiting
Near-infrared monitoring to guide cooling in newborns
This study tests a special, non-invasive sensor (near-infrared light) to help doctors choose the best cooling treatment for some newborns after brain injury. It may improve how well cooling works and how safely it’s managed in the first week of life.
Boston, MassachusettsAges Up to 2 years - NCT05553899Recruiting
PET-MRI scans for monitoring children’s brain tumor return
This study checks whether a special scan called PET-MRI can better tell if a child’s brain tumor has come back after treatment. It may help doctors decide faster and more accurately when changes seen on regular MRI are true tumor recurrence.
Sheffield, South YorkshireAges 8–18 - NCT05571579Recruiting
Collecting blood and tissue samples from confirmed brain tumors
This study collects biological samples from adults with a confirmed brain tumor. Samples may help researchers better understand brain tumors and improve future treatments.
Bron, RhôneAges 18 years+ - NCT05588453RecruitingPhase 1/Phase 2
Immunotherapy and temozolomide for melanoma brain metastases
This early-phase study tests an immune cell treatment (natural killer cells) plus temozolomide to treat melanoma that has spread to the brain. It’s for people whose brain spots are getting worse and who are not good candidates for certain types of brain radiation.
Columbus, OhioAges 18 years+ - NCT05557864Recruiting
Brain scan study for Parkinson’s patients with deep brain stimulators
This study looks at how the location of a deep brain stimulator in Parkinson’s disease affects movement problems. It mainly uses advanced 7T brain imaging to compare brain activity and motor symptoms.
Minneapolis, MinnesotaAges 21–89 - NCT05521984RecruitingPhase 1
Dapagliflozin trial for children with hard-to-treat brain tumors
This Phase 1 trial tests whether dapagliflozin (an SGLT2 medicine) can help shrink or control certain pediatric brain tumors or other solid tumors that have come back or won’t respond. It’s designed mainly to check safety and early signs of effect in children and young adults who have limited treatment options.
St Louis, MissouriAges 6–21 - NCT05506085Recruiting
Brain stimulator study for voice spasms with tremor
This trial studies a brain stimulation approach for a specific voice disorder that can include tremor. It aims to better understand how well the treatment works and how to use it more effectively while carefully checking safety with awake procedures.
Indianapolis, IndianaAges 18–70 - NCT05277558Recruiting
MRI and brain testing in teens at risk for type 2 diabetes
This study looks at brain health in teens with normal weight, overweight, or obesity who are at risk for type 2 diabetes. It may help researchers understand how weight and diabetes risk affect the brain, using MRI scans and learning/memory tests.
St Louis, MissouriAges 12–17 - NCT05380050Recruiting
Comparing online and in-person memory training for veterans with mild brain injury and PTSD
This study compares two ways of delivering a memory and thinking skills program to veterans with both mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). The goal is to see if doing the training online is as effective as doing it in person, which could make it easier for more veterans to get help.
Gainesville, FloridaAges 30–55 - NCT05376878RecruitingPhase 4
PET/MRI scan to guide treatment in HER2+ brain metastatic breast cancer
This trial tests a special PET/MRI imaging scan using a labeled drug to help doctors evaluate HER2+ breast cancer that has spread to the brain. It focuses on patients who plan to receive fam-trastuzumab deruxtecan, a targeted cancer medicine, and aims to see how well the scan can support treatment decisions.
Duarte, CaliforniaAges 18 years+ - NCT05402761Recruiting
Nurse-guided sleep program for insomnia after brain injury
This trial studies whether nurse-guided behavioral sleep therapy can improve insomnia in people recovering after a traumatic brain injury (TBI). It may help you sleep better by targeting sleep habits and insomnia symptoms.
TaipeiAges 20–65 - NCT05342454Recruiting
Brain tumor surgery patients using brain scan and mapping software
This study checks a new computer software tool that helps doctors map important brain networks and how blood flow responds during brain scans. It may help improve planning and safety for people having brain tumor surgery.
Houston, TexasAges 18 years+ - NCT05331521RecruitingPhase 3
Study to improve brain function in newly diagnosed glioma patients
This Phase 3 study tests a treatment plan after surgery to improve brain function and quality of life in adults with newly diagnosed, specific types of brain tumors (gliomas). It may help you keep thinking clearly and living better while your tumor is treated with standard medicines.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT05327829RecruitingEarly Phase 1
Testing a brain-stimulation approach after concussion recovery
This early study tests whether a brain-stimulation method can help after recovery from a mild to moderate traumatic brain injury (TBI), sometimes called concussion. It also may include healthy volunteers to compare safety and computer-based brain measures.
Minneapolis, MinnesotaAges 18 years+ - NCT05303649Recruiting
Theta burst brain stimulation for language problems after stroke
This study tests whether a type of brain stimulation guided by a brain scan (MRI) can improve speech and language (“aphasia”) after a stroke. It may help people who have trouble producing speech but can still understand others’ words.
Warsaw, Masovian VoivodeshipAges 18–75 - NCT05205174Recruiting
Check a scalp sensor to detect brain swelling after injury
This study tests whether a sensor on the scalp can detect a wave of abnormal electrical activity in the brain after a traumatic brain injury (TBI). The goal is to help clinicians monitor and possibly treat dangerous pressure build-up in the brain.
Minneapolis, MinnesotaAges Any age - NCT05222620RecruitingPhase 2
SRS methods for untreated brain metastases under 4 cm
This trial compares two stereotactic radiation strategies for patients who have intact (not previously radiated) brain metastases that are limited in size. It aims to see which approach works best in controlling the cancer while reducing side effects.
Scottsdale, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,015 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.