Clinical trials
Ischemia Limb clinical trials
Below are recruiting ischemia limb clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT07270562Recruiting
Orbital atherectomy for severe leg circulation problems
This trial tests a special tool (orbital atherectomy) to remove hard calcium buildup from leg arteries in people with severe leg circulation problems. It may help restore blood flow and prevent amputation.
HullAges 18 years+ - NCT07270575Recruiting
Resorbable stents for leg artery disease with limb threat
This trial tests a special scaffold that slowly releases medicine to open blocked arteries below the knee. It is for people whose leg pain or wounds are severe enough to threaten the limb.
HullAges 18 years+ - NCT06066268Recruiting
miRNAs in Critical Limb Ischemia Study
This study looks at small molecules called miRNAs in the blood of people with severe leg artery disease (critical limb ischemia) or belly aortic aneurysm. The goal is to find patterns that may help doctors better understand and treat these conditions.
San Donato Milanese, MilanAges 40–85 - NCT05830721Recruiting
Monitoring leg pressure in adults on life-support
This trial tests a device that continuously measures pressure in an arm or leg to help detect compartment syndrome in people on a heart-lung machine (VA-ECMO). It may help clinicians act sooner if pressure becomes dangerous, potentially reducing complications.
Baltimore, MarylandAges 18 years+ - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT07832578RecruitingEarly Phase 1
Aspirin with or without rivaroxaban for severe leg artery disease
This trial compares two ways to prevent blood clots in people with severe leg blockage (chronic limb-threatening ischemia) who are not having surgery. It tests aspirin alone versus a newer blood thinner (rivaroxaban) plus aspirin, to see which works better in preventing complications.
Lahore, Punjab ProvinceAges 40–70 - NCT06238050Recruiting
Oxygen therapy for severe leg artery disease
This trial tests whether breathing pure oxygen at normal pressure can help people with severe, long-lasting lack of blood flow in their legs. It may offer a way to improve oxygen delivery to the leg and possibly avoid amputation.
AngersAges 18 years+ - NCT03529019RecruitingEarly Phase 1
Nutrition study for poor blood flow to a limb
This early-phase study looks at how nutrition affects people who have very poor blood flow to a limb (critical limb ischemia). It’s exploring whether nutrition changes health outcomes and safety for this condition.
Boston, MassachusettsAges 18–99 - NCT06544135Recruiting
Thermal camera study for blood flow in PAD with tissue loss
This study uses a special camera that detects heat to see blood flow in your leg before and after a procedure to open blocked arteries.
Beachwood, OhioAges 18–99 - NCT07068789Recruiting
Leg Artery Bypass: One vs. Multiple Vessels for Severe Limb Threat
This trial compares opening up one versus multiple blood vessels below the knee to improve blood flow in people with severe leg pain or wounds. It aims to find the best approach to save the limb and improve quality of life.
Sohag, Sohag GovernorateAges 40 years+ - NCT04312451Recruiting
Study of severe leg blood-flow problems after a procedure
This study follows adults with very poor blood flow to the foot or leg (with wounds or severe pain) who are having a revascularization procedure to improve circulation. It may help doctors understand outcomes after treatment and improve care for people with critical limb ischemia.
ParisAges 18 years+ - NCT07335341Recruiting
Liberant thrombectomy system case survey
This survey collects feedback from doctors who used the Liberant system to remove blood clots. The results help understand how well the device works in real-life procedures.
Washington D.C., District of ColumbiaAges 22 years+ - NCT07536373RecruitingPhase 3
Colchicine to prevent amputation after leg artery treatment
This study tests whether a medication called colchicine can help prevent amputation in people with severe leg blood flow problems who just had surgery or a catheter procedure to restore blood flow. Colchicine is an anti-inflammatory drug that may help protect the leg tissue after treatment.
Taipei, TaipeiAges 18 years+ - NCT07387653Recruiting
Leg circulation monitoring during pelvic surgery
This trial tests a new way to check blood flow and oxygen levels in your legs during pelvic surgery when you're in the lithotomy (legs-up) position. It aims to catch any circulation problems early, which could help prevent leg injuries.
Houston, TexasAges Any age - NCT05854615RecruitingPhase 4
Stem cell treatment for painful poor blood flow in limbs
This trial tests whether a stem cell product (Stempeucel®) is safe and effective for people with Buerger’s disease causing critical limb ischemia and foot ulcers. It may help improve healing and blood flow when other options may be limited.
Kuala LumpurAges 18–65 - NCT05854641RecruitingPhase 4
Stem cell treatment for poor blood flow in the leg ulcers
This trial tests whether a stem cell product (Stempeucel®) can improve healing and safety for people with critical limb ischemia caused by peripheral artery disease. It is for patients who cannot have (or have already tried) procedures to reopen blocked leg arteries and who have a leg ulcer and low blood-flow measurements.
Kuala LumpurAges 18–65 - NCT06277362Recruiting
New Leg-Saving Treatment for Critical Limb Ischemia
This study tests a new way to restore blood flow to the leg in people who have wounds or dead tissue on their foot and have run out of other treatment options. It's for those who have already tried angioplasty twice without success or have severely hardened small arteries.
Ancona, AnconaAges 18 years+ - NCT07352800RecruitingPhase 2
Study of APAC for peripheral artery disease and severe leg ischemia
This trial tests a new drug called APAC to see if it safely prevents blood clots and improves blood flow in people with narrowed leg arteries. It may help those with severe symptoms like pain at rest or non-healing wounds, or those with claudication (leg pain when walking).
HelsinkiAges Up to 85 years - NCT06747117Recruiting
Removing blood clots in leg arteries with the Indigo system
This study tests a device that vacuums out blood clots from blocked leg arteries, potentially restoring blood flow without open surgery.
Scottsdale, ArizonaAges 18 years+ - NCT07023965Enrolling by invitation
Long-term follow-up study for gene therapy in critical limb ischemia
This study follows up with people who previously took part in a clinical trial testing an experimental gene therapy for critical limb ischemia (severe leg pain or sores due to blocked arteries). It aims to see how well the treatment works over time. If you were in that earlier trial and received at least one dose, joining this follow-up could help researchers learn more about the therapy's lasting effects.
Beijing, Beijing MunicipalityAges 20–85 - NCT06226844Recruiting
Can a vibration device help people with leg artery disease walk further?
This study tests a device called BeatMove to see if it can improve walking distance for people with blocked leg arteries that cause pain when walking. It may help if you have this condition and already take medicines for it.
NîmesAges 18 years+ - NCT06979284Recruiting
Ultrasound-guided angioplasty for severe leg pain or wounds
This study tests whether using a special ultrasound probe inside the artery during a leg procedure helps doctors open blockages more safely and effectively. It aims to improve blood flow and save the leg for people with severe peripheral artery disease who have pain, wounds, or gangrene.
Montreal, QuebecAges 18 years+ - NCT06473740RecruitingPhase 4
Gene therapy plus angioplasty for severe leg blockages
This study tests if adding gene therapy to a standard leg artery-opening procedure (angioplasty or stenting) helps people with severe leg pain or non-healing wounds due to blocked arteries. It may improve blood flow and save the leg from amputation.
Blagoveshchensk, Amur OblastAges 18 years+
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Common questions
- Are there clinical trials for ischemia limb?
- Yes. Clin2 currently lists 55 recruiting ischemia limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ischemia limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ischemia limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.