Clinical trials
Chronic Obstructive Pulmonary Disease Severe clinical trials
Below are recruiting chronic obstructive pulmonary disease severe clinical trials, each written for real people, not researchers. We’re tracking 212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05279742Enrolling by invitationPhase 1/Phase 2
Study drug to boost a hormone system in HFpEF
This early-phase trial tests a treatment that aims to improve the “natriuretic peptide” hormone system in people with HFpEF (heart failure with preserved pumping strength). It may help reduce symptoms and improve heart and fluid pressure behavior, especially in certain related conditions like kidney disease.
Rochester, MinnesotaAges 18 years+ - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT07191860Recruiting
Coated balloon for non-cancerous airway narrowing
This trial tests a special balloon coated with a medicine (paclitaxel) to open narrowed windpipes. It is for people whose windpipe is blocked by scar tissue from a ventilator, transplant, or other non-cancer causes, not from cancer.
Baltimore, MarylandAges 22 years+ - NCT06377449Recruiting
Lung ultrasound for better outcomes after heart surgery
This study tests whether using ultrasound to look at the lungs during and after heart surgery helps improve recovery. You may be eligible if you are having open-heart surgery with a heart-lung machine and meet certain health criteria.
Saint Petersburg, Sankt-PeterburgAges 18 years+ - NCT04750564Recruiting
BreEStim to help arm movement after long-term stroke
This pilot study tests a type of nerve stimulation (BreEStim) to improve arm and finger movement in people with chronic stroke-related stiffness. It may help if you have persistent, measurable muscle tightness and are medically stable.
Houston, TexasAges 18–75 - NCT06578234RecruitingPhase 4
Comparing Adenosine Doses for Heart MRI
This study will compare different doses of adenosine during a heart MRI to find the best dose for measuring blood flow to the heart muscle. It is for people with known or possible coronary artery disease or heart failure, as well as healthy volunteers.
LundAges 40 years+ - NCT07723144Recruiting
Identifying sleep apnea biomarkers
This study compares blood samples from people with moderate-to-severe sleep apnea and those without sleep apnea to find markers that could help diagnose or treat the condition. Half of those with sleep apnea will start CPAP therapy right away, while others wait before starting.
Bialystok, Podlaskie VoivodeshipAges 18–65 - NCT06732674Recruiting
Home-based care for lung disease in rheumatic conditions
This trial tests whether people with lung disease caused by a rheumatic condition can safely manage their care at home using a smartphone or tablet. It aims to see if home monitoring is as effective as in-person visits for keeping your lungs healthy.
OsloAges 18 years+ - NCT06069115Recruiting
How radiation affects lung function in breast cancer patients
This study looks at how radiation therapy for breast cancer may affect your lungs over time. Researchers will measure lung function and see if problems develop, so they can better understand and protect patients.
Novosibirsk, Novosibirsk OblastAges 18 years+ - NCT02630121RecruitingPhase 4
Nasal spray treatment to reduce mild sleep apnea congestion
This study tests whether using oxymetazoline with fluticasone nasal spray can improve mild obstructive sleep apnea by lowering nasal congestion. If your nose stays blocked most days despite current spray use, this may help your breathing during sleep.
Tampa, FloridaAges 18–65 - NCT07245680RecruitingPhase 3
Testing two pills vs one for pulmonary hypertension with heart or metabolism issues
This trial compares starting with two oral medications versus one for people newly diagnosed with pulmonary arterial hypertension (PAH) who also have conditions like high blood pressure, diabetes, obesity, or heart disease. The goal is to see if a two-drug approach works better for patients with these additional health issues.
Le Kremlin-BicêtreAges 18 years+ - NCT07048808RecruitingPhase 2
Gene therapy for chronic chest pain
This trial tests a new gene therapy (XC001) delivered through a thin tube into your heart's blood vessels. It aims to grow new blood vessels to relieve chest pain in people with chronic angina who have no other treatment options.
Birmingham, AlabamaAges 18–85 - NCT07709754Recruiting
Lung stimulation for hard-to-control asthma
This trial tests a device that stimulates the lung to help people whose asthma is not controlled by standard treatments. It may offer a new option for those who still have symptoms despite using inhalers or biologic medicines.
Denver, ColoradoAges 18–75 - NCT07090395Recruiting
Expanding use of EVO oral appliance for severe sleep apnea
This trial tests whether an EVO oral appliance can treat severe obstructive sleep apnea in people who haven't used other treatments recently. It aims to see if the device works for a wider group of patients.
New York, New YorkAges 18–80 - NCT05655897Recruiting
Clips for leaky mitral valve in high-surgery-risk heart patients
This trial studies whether a device called GeminiOne can safely and effectively repair a leaky mitral valve using a catheter-based “clip” technique. It may help patients who have moderate-to-severe or severe valve leakage but are considered too high-risk for open surgery.
Suzhou, JiangsuAges 18 years+ - NCT05738720Recruiting
Home breathing rehab to reduce COPD flare-ups and hospital visits
This trial tests whether a breathing and exercise program done at home can lower COPD flare-ups and the chance of needing hospital care. It may help people with more severe COPD manage breathlessness and stay stable.
IstanbulAges 18–75 - NCT05009758Recruiting
Asthma and nasal polyps study to match immune patterns
This study looks at different “immune inflammation patterns” in people with asthma and/or nasal polyps. It may help researchers better tailor future treatments by figuring out which patterns go with which symptoms.
ViennaAges 18–99 - NCT06575426RecruitingPhase 1/Phase 2
Pig pancreatic cell transplant for type 1 diabetes
This trial tests a new treatment made from pig pancreatic cells (called OPF-310) that are placed under the skin to help control blood sugar in people with type 1 diabetes. It is for those whose diabetes is difficult to manage and who have dangerous low blood sugar episodes.
Chicago, IllinoisAges 35–70 - NCT06851767Enrolling by invitationPhase 1/Phase 2
Gene therapy for X-linked severe combined immunodeficiency
This study tests a gene therapy to treat X-linked severe combined immunodeficiency (X-SCID) without a stem cell transplant from a matched sibling. It aims to improve immune function and reduce infections using your own stem cells modified to carry the correct gene.
Bethesda, MarylandAges 3–99 - NCT01306019RecruitingPhase 1/Phase 2
Gene therapy for children with severe immune deficiency (XSCID)
This trial tests a one-time gene therapy approach to help children with X-linked SCID (a serious inherited immune disorder) make better immune cells. It’s for people who don’t have a fully matched sibling donor and need long-term follow-up after treatment.
Bethesda, MarylandAges 2–50
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Common questions
- Are there clinical trials for chronic obstructive pulmonary disease severe?
- Yes. Clin2 currently lists 212 recruiting chronic obstructive pulmonary disease severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic obstructive pulmonary disease severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic obstructive pulmonary disease severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.