Clinical trials
Degenerative Disease clinical trials
Below are recruiting degenerative disease clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04601363Recruiting
Personalized spine registry for people with spinal hardware
This registry follows people who recently had spinal surgery where custom (patient-specific) spine hardware (like rods) was placed. It collects consent and health questionnaires to learn how these implants affect patients over time.
Aurora, ColoradoAges 10–85 - NCT04631133Recruiting
Study of outcomes after surgery using the LISA implant
This study follows adults who get back surgery using the LISA implant to see how well they do afterward and how outcomes change over time. It focuses on people whose long-term, non-surgical care did not relieve low-back pain from specific age-related disc changes.
SilkeborgAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT05329129Recruiting
Spine surgery registry to track recovery with bone graft
This study follows people who are having spinal fusion surgery using an OssDsign bone graft. It collects health and scan information over time to better understand recovery and outcomes after surgery.
Fresno, CaliforniaAges 21 years+ - NCT05357378Recruiting
Hip replacement study using a reverse hip implant
This trial looks at how safe and well a specific “reverse” hip implant works in people who need their first total hip replacement. It may help by improving pain and hip function, while closely tracking safety during and after surgery.
Miami, FloridaAges 50–75 - NCT05701059Recruiting
Tests different artificial discs for neck nerve and spinal cord problems
This trial compares two types of artificial disc implants used for certain neck problems. It may help people who have tried non-surgical treatments but still have ongoing nerve symptoms or spinal cord issues from a damaged disc in the neck.
Los Angeles, CaliforniaAges 18–60 - NCT05997121Recruiting
Testing a new spinal implant for degenerative disc disease
This trial studies a new spinal implant system (Hexanium TLIF) for people with degenerative disc disease. It aims to see if the implant is safe and works well to help with back pain and stability.
BrugesAges 18 years+ - NCT06108934Recruiting
Study of the Insignia Hip Stem for First Hip Replacement
This study tests a new cementless hip stem (Insignia) for people having their first total hip replacement. It aims to see how long the implant lasts and how well your hip works after surgery.
Subiaco, Western AustraliaAges 18 years+ - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT06383949Recruiting
Real-world study of Synergy Disc implant
This study follows people who receive a Synergy Disc implant to treat neck pain or nerve problems. It collects real-world information on how well the disc works and how safe it is over time.
DublinAges 21 years+ - NCT06490887Recruiting
Spine unit modeling with high-throughput analysis (SUIT)
This study looks at cells from people with degenerated discs or from donated fat or placenta tissue. It aims to understand how these cells work and might help develop new treatments for back pain.
Milan, MIAges 18–60 - NCT06704919Recruiting
Spinal fusion using conduit cages and bone graft putty
This trial tests a new combination of a cage and bone graft putty for spinal fusion surgery. It is for people with degenerative disc disease or a herniated disc in the neck or lower back that needs surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05037968Recruiting
Test bone graft materials for multi-level back fusion surgery
This trial compares two bone-graft materials to help bones heal after back fusion surgery using a rod/screw system. It may help people who have ongoing back or leg pain despite at least 3 months of non-surgical treatments.
Hartford, ConnecticutAges 18 years+ - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT07125833Recruiting
Cold therapy for shoulder replacement pain
This trial tests if freezing a nerve near the shoulder before surgery can reduce pain after a reverse total shoulder replacement. It may help you recover with less discomfort.
Rockwall, TexasAges 30–85 - NCT07168603RecruitingPhase 1/Phase 2
Testing own disc cells for low back pain from a herniated disc
This trial tests whether your own disc cells (nucleus pulposus cells) can help heal a herniated disc and reduce pain. It is for people who have had low back pain for more than six weeks and are scheduled for disc surgery.
TaipeiAges 20 years+ - NCT07267793Recruiting
Long-term study of CartiPRO for knee pain
This trial tests a treatment called CartiPRO for knee pain caused by osteoarthritis or cartilage damage. It looks at how well the treatment works over a long period and is for people who have a certain type of knee pain that hasn't improved with other treatments.
Seongnam-si, Bundang-guAges 19 years+ - NCT07533188Recruiting
Robotic Knee Replacement Surgery Alignment Techniques Study
This study compares two different ways surgeons can align and position a robotic knee replacement to see which gives better results. You'll be randomly assigned to one approach and tracked over time to measure pain, function, and satisfaction.
SingaporeAges 18 years+ - NCT07615491Recruiting
Safety and effectiveness study of spinal implants and bone materials
This study tracks how well spinal implants (Titania systems) and bone-filling materials (BONEGRAFT) work after surgery and whether patients experience any problems. Researchers will follow patients after cervical or lower spine surgery to confirm these devices are safe and effective in real-world use.
IzmirAges 18 years+ - NCT06971835Enrolling by invitation
NanoParticle Matrix spine surgery registry
This study follows people who receive a special bone graft material called NanoParticle Matrix (NPM) during spine surgery. Researchers want to track outcomes over two years to see how well it works.
Baton Rouge, LouisianaAges 18 years+ - NCT06686017Enrolling by invitation
New bone graft for lower back fusion surgery
This trial studies a new bone graft material called Virtuos for use in lower back spinal fusion surgery. It may help patients needing a one or two-level lumbar fusion by providing a safe and effective option for bone healing.
South Bend, IndianaAges 18 years+ - NCT06415136Enrolling by invitation
Comparing two ways to fuse neck bones after prior surgery
This study tests two methods for adding a new fusion to the level next to a previous neck surgery. It compares using a special plate system versus removing the old plate and putting in a new one.
Southfield, MichiganAges 18 years+
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Common questions
- Are there clinical trials for degenerative disease?
- Yes. Clin2 currently lists 117 recruiting degenerative disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.