Clinical trials · Florida
Depression clinical trials in Florida
We’re tracking 74 recruiting depression studies with a site in Florida — including Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Florida
- NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Clermont, FloridaAges 18–65 - NCT05877885Recruiting
Digital treatment for low motivation in older adults with depression
This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.
Orlando, FloridaAges 60 years+ - NCT06132581Recruiting
Brain stimulation for pleasure loss in depression
This study tests a new type of brain stimulation to see if it can help people with depression who have lost the ability to feel pleasure. It uses MRI scans to guide the treatment and may help improve motivation and goal-setting.
Tallahassee, FloridaAges 18–65 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Doral, FloridaAges 18–65 - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Tampa, FloridaAges 22–70 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Tampa, FloridaAges 18–65 - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Jacksonville, FloridaAges 18–64 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Brandon, FloridaAges 18–74 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Brandon, FloridaAges 18–65 - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Fort Myers, FloridaAges 10–17 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Hollywood, FloridaAges 18 years+ - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Tampa, FloridaAges 18–65 - NCT06967259RecruitingPhase 1
Testing ENA-001 for Opioid-Related Breathing Problems
This study tests a new medicine (ENA-001) that helps restore normal breathing when it has slowed down too much due to opioid painkillers. Healthy volunteers will receive the drug to see how safe it is and how the body handles it.
Miami, FloridaAges 18–55 - NCT07032363Recruiting
Depression and HIV treatment support study
This study tests a program that helps people with HIV manage depression and stick to their treatment. It's for adults in Cape Town, South Africa, who have a detectable HIV viral load or may have one, and who show signs of depression.
Miami, FloridaAges 18 years+ - NCT07112001Recruiting
Mobile app for anxiety and depression in HIV
This study tests a mobile health program to help people with HIV manage symptoms of anxiety and depression. It is designed to offer support through your phone and may improve your mood and overall health.
Gainesville, FloridaAges 18–90 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Jacksonville, FloridaAges 18–64 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Miami, FloridaAges 18–65 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Miami, FloridaAges 18–75 - NCT07349706Recruiting
Breathing exercise for dementia risk reduction
This trial tests a simple breathing exercise done for about 5–10 minutes each day for 8 weeks. It aims to see if this exercise can reduce your risk of dementia. If you are between 60 and 80 years old and have at least one risk factor for dementia, this study may be a fit for you.
Tallahassee, FloridaAges 60–80 - NCT07413705Recruiting
Devices for depression and sexual health in menopause
This study tests two devices (BTL-699-2 and HPM-6000UF) to see if they can improve depression symptoms and sexual function in women going through menopause or perimenopause. It may help with mood and intimacy during this life stage.
Winter Garden, FloridaAges 40 years+ - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Saint Augustine, FloridaAges 18–75 - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Coral Gables, FloridaAges 18–75 - NCT05426057Recruiting
Mental health support for Hispanic teens with caregiver involvement
This study looks at improving mental health in primary care by involving both a teen and an adult caregiver. It may help families who are struggling with communication, depression or anxiety symptoms, or past suicidal thoughts or behaviors.
Miami, FloridaAges 12–16 - NCT06057337Recruiting
Families with pride for Hispanic LGBTQ+ teens
This study helps Hispanic LGBTQ+ teens and their families build stronger bonds and pride. It includes family activities and conversations to support your identity and well-being.
Coral Gables, FloridaAges 13–19
Depression trials by city in Florida
Where these studies are running in Florida
Institutions with a site for the recruiting depression studies listed above.
- Clinical Neuroscience Solutions, Inc. · 5 studies
- Premier Clinical Research Institute, Inc. · 3 studies
- Advanced Research Institute of Miami · 2 studies
- Aqualane Clinical Research · 2 studies
- CenExel · 2 studies
- Equipath Health and Research Tampa Bay · 2 studies
- Florida State University · 2 studies
- Health Synergy Clinical Research · 2 studies
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Florida?
- Yes. We're currently tracking 74 recruiting depression studies with a site in Florida, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Florida?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Florida to take part?
- Not necessarily. These studies have a site in Florida, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Florida regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.