Clinical trials
Heart Failure NYHA Class III clinical trials
Below are recruiting heart failure nyha class iii clinical trials, each written for real people, not researchers. We’re tracking 134 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07272902Recruiting
Atrial fibrillation treatment: Ablation vs. medication
This trial compares two ways to treat atrial fibrillation in people with heart failure where the heart's pumping strength is still normal. You'll either get a procedure called ablation to restore normal rhythm or medication to control your heart rate. The goal is to see which approach works better for people like you.
Halifax, Nova ScotiaAges 18 years+ - NCT02537769Recruiting
Surgery to fix a leaky tricuspid valve in LVAD patients
This study looks at whether fixing a mildly leaky tricuspid valve during LVAD surgery improves outcomes for people with advanced heart failure. It’s mainly aimed at patients who are already scheduled to receive an implantable LVAD.
Seattle, WashingtonAges 18 years+ - NCT03180320Recruiting
Exercise program for chronic heart failure with confidence building
This trial studies whether a specific gentle exercise routine (Baduanjin, “eight-silken-movement”) plus skills to build self-confidence can help people with chronic heart failure. It’s meant for people who are stable and can do prescribed exercise testing and sessions.
Guangzhou, GuangdongAges 18 years+ - NCT07442903Recruiting
Tricuspid valve repair with remote pressure monitoring
This trial tests a new way to closely monitor heart function during tricuspid valve repair or replacement. A tiny sensor is placed in your lung artery to track pressure, helping doctors adjust your care remotely.
MunichAges 18 years+ - NCT07496372RecruitingPhase 3
Stem cell injection for advanced heart failure
This trial tests a treatment made from stem cells that are turned into heart muscle cells and injected directly into the heart. It is for people with advanced heart failure who are already on the best available medicines and who are scheduled to have bypass surgery.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07649148Recruiting
Tracking What You Eat to Help Your Heart
This study asks people with moderate heart failure to use a food-tracking app and work with a coach to eat fewer ultra-processed foods. Researchers want to see if changing your diet this way can improve how you feel and how well your heart works.
Cleveland, OhioAges 18 years+ - NCT07204834Enrolling by invitation
Physical activity program for heart failure
This study tests a home-based physical activity program for people with heart failure. The program is designed to be safe and easy to follow, using a smartphone app to guide you, and may help you feel stronger and more active.
GranadaAges 18 years+ - NCT07064525Enrolling by invitationPhase 2
Testing a new drug for high blood pressure
This trial tests a new medicine called SPC1001 Low to see if it can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). If you are between 19 and 75 years old and have mild to moderate high blood pressure, this study might be an option.
SeoulAges 19–75 - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06299176Enrolling by invitationPhase 1
Whole-heart radiation therapy for advanced heart failure
This trial tests if a low dose of radiation to the whole heart can help people with very advanced heart failure. It is for people who have severe symptoms despite maximum medications and are not candidates for a heart pump or transplant.
Montreal, QuebecAges 65 years+ - NCT07335510Recruiting
Baroreflex therapy for heart failure patients
This trial tests a device that stimulates a nerve in your neck to help your heart pump better. It is for people with heart failure and a weak heart pump who still have symptoms despite taking medications.
San Francisco, CaliforniaAges 18 years+ - NCT06036615Recruiting
Exercise training for frailty and fall risk in heart failure
This trial tests whether a supervised exercise program can reduce frailty and fall risk in people with chronic heart failure, and what happens when training stops. It may help you feel stronger and more stable.
Thessaloniki, ThermiAges 18–100 - NCT07695090RecruitingPhase 2
Lumacaftor for improved brain blood flow in heart failure
This trial tests if lumacaftor, a medication used in cystic fibrosis, can improve blood flow to the brain in people with stable heart failure. It might help if you have heart failure with reduced pumping function and low brain blood flow.
Toronto, OntarioAges 18 years+ - NCT06350695Recruiting
Compression stockings for heart failure with leg swelling
This trial tests whether wearing compression stockings can help people with heart failure who have leg swelling. Researchers want to see if stockings reduce fluid buildup and improve daily life.
Dallas, TexasAges 18 years+ - NCT06425848Recruiting
Heart failure monitoring study
This study looks at how a small monitor inside the blood vessel to the lungs helps manage heart failure. It aims to improve care for people with advanced heart failure.
La Jolla, CaliforniaAges 18–100 - NCT07402239Recruiting
Heart failure therapy and monitoring device study
This trial tests a device that treats and monitors heart failure. It may help people with chronic heart failure and reduced heart function who still have symptoms despite standard treatments.
Fuzhou, FujianAges 18 years+ - NCT07166965Enrolling by invitation
Supplement for Heart Failure: Ketones and Hawthorn
This trial tests whether adding a supplement containing ketones and hawthorn extract can help people with heart failure feel better and improve their heart function. You will take the supplement daily and have imaging scans and exercise tests to monitor your progress.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06927440Enrolling by invitation
Registry for children with severe heart failure in China
This study is creating a registry to learn more about children with advanced heart failure. It will help doctors understand who can benefit from treatments like medicine, devices, or transplants.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT07689760Enrolling by invitation
AI to Predict Hospital Readmission in Heart Failure
This study uses artificial intelligence (AI) to predict when people with heart failure might need to go back to the hospital. It's designed for patients who are already in a telemonitoring program and use an iPhone to track their health.
EnschedeAges 18 years+ - NCT04707261RecruitingPhase 4
Testing how dapagliflozin affects anemia in heart failure
This trial studies whether dapagliflozin (a heart-failure medicine) can improve anemia in people with heart failure. It may help explain why some patients feel better and how anemia changes when this medicine is used.
Xiangtan, HunanAges 18–100 - NCT05562167RecruitingPhase 2
Inorganic nitrate plus exercise for heart failure performance
This Phase 2 study tests whether taking inorganic nitrate can improve exercise ability and heart-function symptoms in people with heart failure with reduced pumping. It also checks whether the treatment is safe when combined with an exercise program.
St Louis, MissouriAges 19–79 - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT06427343RecruitingPhase 4
IV iron: low dose vs high dose for heart failure with low iron
This study compares two different doses of IV iron (low vs high) to see which works better for people with heart failure and low iron levels. It may help you feel less tired and breathe easier.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06578078RecruitingPhase 3
Best heart failure care for older patients with kidney disease
This study tests the best way to manage heart failure in older adults who also have kidney problems and high potassium levels. It compares different treatment strategies to see which one is safest and most effective.
Alcorcón, MadridAges 70 years+
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Common questions
- Are there clinical trials for heart failure nyha class iii?
- Yes. Clin2 currently lists 134 recruiting heart failure nyha class iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.