Clinical trials
Heart Failure NYHA Class III clinical trials
Below are recruiting heart failure nyha class iii clinical trials, each written for real people, not researchers. We’re tracking 130 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07209098Recruiting
Heart failure study testing CCM therapy
This study tests a therapy called Cardiac Contractility Modulation (CCM) for people with heart failure. It uses a device to help the heart pump more strongly, and researchers compare it to standard care using patient records.
Marlton, New JerseyAges 18 years+ - NCT07204834Enrolling by invitation
Physical activity program for heart failure
This study tests a home-based physical activity program for people with heart failure. The program is designed to be safe and easy to follow, using a smartphone app to guide you, and may help you feel stronger and more active.
GranadaAges 18 years+ - NCT06831825RecruitingPhase 1
Gene therapy for heart failure recovery trial
This trial tests a gene therapy injected into the heart to help it recover after a previous heart attack. It may be an option for people with stable heart failure who are not eligible for standard procedures like stents or bypass surgery.
Houston, TexasAges 18–79 - NCT03180320Recruiting
Exercise program for chronic heart failure with confidence building
This trial studies whether a specific gentle exercise routine (Baduanjin, “eight-silken-movement”) plus skills to build self-confidence can help people with chronic heart failure. It’s meant for people who are stable and can do prescribed exercise testing and sessions.
Guangzhou, GuangdongAges 18 years+ - NCT07064525Enrolling by invitationPhase 2
Testing a new drug for high blood pressure
This trial tests a new medicine called SPC1001 Low to see if it can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). If you are between 19 and 75 years old and have mild to moderate high blood pressure, this study might be an option.
SeoulAges 19–75 - NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT07023536Recruiting
Heart rehab program from home for chronic heart failure
This trial tests a cardiac telerehabilitation program for people with chronic heart failure. It is designed to see if doing rehab at home using digital tools helps improve health and quality of life.
SalernoAges 18 years+ - NCT06989580Recruiting
Heart failure monitoring with a wireless implant
This trial is testing a special monitor (BIOMONITOR) that tracks your heart function and sends data wirelessly to your doctor. It aims to help manage heart failure by catching early signs of trouble so you can get treatment sooner.
GenkAges 18 years+ - NCT06961929Recruiting
Heat and Heart Failure Study
This study looks at how heat affects the body in people with stable heart failure compared to healthy volunteers. It may help researchers understand how to better manage heart failure in daily life.
Dallas, TexasAges 45 years+ - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT06455878Recruiting
Mobile app for weight loss in heart failure patients
This trial tests a mobile app that helps you track your diet to manage your weight. It is designed for people with heart failure who are overweight and have recently been in the hospital for their condition.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06783335Recruiting
Cordella sensor for chronic heart failure
This trial studies a small sensor placed in the lung artery to help manage chronic heart failure. It compares patients who get the sensor to those who receive standard care, to see if the sensor improves outcomes.
Naperville, IllinoisAges 18 years+ - NCT06791850Recruiting
Home heart failure support for rural patients and caregivers
This trial tests a home-based palliative care program for people with advanced heart failure living in rural areas and their caregivers. It aims to improve quality of life and reduce symptoms.
Morgantown, West VirginiaAges 45–80 - NCT06661876Recruiting
Heart radiation therapy for heart failure
This trial tests if a low dose of radiation to the heart can help people with advanced heart failure feel better and improve heart function. It is for patients whose heart failure is stable but severe, and who are already on the best medications.
LeuvenAges 18 years+ - NCT06306573Enrolling by invitation
CardioMEMS heart pressure monitor study in Medicare patients
This study looks at how well the CardioMEMS heart pressure monitor works for people with heart failure who are on Medicare. It gathers real-world information to see if the sensor helps improve health outcomes.
Atlanta, GeorgiaAges 18 years+ - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Birmingham, AlabamaAges 18–100 - NCT06299176Enrolling by invitationPhase 1
Whole-heart radiation therapy for advanced heart failure
This trial tests if a low dose of radiation to the whole heart can help people with very advanced heart failure. It is for people who have severe symptoms despite maximum medications and are not candidates for a heart pump or transplant.
Montreal, QuebecAges 65 years+ - NCT06258447Recruiting
CardiAMP bone marrow cell therapy for heart failure
This trial tests a new treatment using your own bone marrow cells to help your heart pump better. It's for people with heart failure after a heart attack whose heart function is moderately reduced.
Clearwater, FloridaAges 21–90 - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05873634Recruiting
Using health records and testing to study heart failure types
This study combines electronic health record data and detailed heart testing to better understand different heart failure types and what treatments may work best for each. It mainly enrolls people with known heart failure, and also some people without heart failure for comparison.
Sacramento, CaliforniaAges 30 years+ - NCT04970888Recruiting
Exercise program to improve thinking and brain blood flow in heart failure
This trial tests whether doing a combined mental (cognitive) and physical exercise program can improve thinking and how well blood flows to the brain in people with chronic heart failure. It may help by strengthening both brain function and physical capacity while your heart condition stays stable.
Montreal, QuebecAges 50 years+ - NCT05650541Recruiting
Testing a home device to help chronic heart failure
This study tests whether a CardioPulmonary Management (CPM) system device used at home is safe and can improve outcomes for people with chronic heart failure. It may help manage symptoms and reduce complications, especially for higher-risk patients.
Palm Springs, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for heart failure nyha class iii?
- Yes. Clin2 currently lists 130 recruiting heart failure nyha class iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.