Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 949 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06979362RecruitingPhase 2
Testing a new medicine for heart failure with thickened heart muscle
This study tests an experimental medicine, CDR132L, to see if it can improve heart structure and function in people with a type of heart failure where the heart muscle is thickened. If you have heart failure with normal pumping function and thickened heart walls, this trial may offer access to a new potential treatment.
Birmingham, AlabamaAges 40–84 - NCT06445231Recruiting
Heart ultrasound study for nursing home residents
This study uses a simple heart ultrasound (echocardiography) to check the heart health of nursing home residents. It may help doctors understand common heart changes in older adults and plan better care.
Nantes, Loire-AtlantiqueAges 65 years+ - NCT06426173Recruiting
Strength training for people waiting for a heart transplant
This study tests whether resistance training (strength exercises) can help people waiting for a heart transplant. It is for patients who have been on the transplant list for less than a month and are stable enough to exercise safely.
São Paulo, São PauloAges 18–70 - NCT06128980RecruitingPhase 2/Phase 3
Stopping heart meds after recovery from fast heartbeat damage
This trial tests if patients whose heart function returned to normal after treating a fast heartbeat can safely stop their heart failure medications. It aims to see if treatment can be withdrawn without the heart problems coming back.
CopenhagenAges 18 years+ - NCT06979375RecruitingPhase 2
Study of CDR132L for heart failure with reduced pumping ability and thickened heart muscle
This trial tests a new medicine called CDR132L to see if it improves heart structure and function in people with heart failure who have a thickened heart muscle and reduced pumping ability. Participants will be randomly assigned to receive either the study drug or a placebo.
Concord, New South WalesAges 40–84 - NCT07112391Recruiting
Pressure volume loop study for valve disease
This trial uses a special heart test called pressure volume loop assessment to better understand how well your heart pumps when you have severe valve disease. It aims to find patterns that may help doctors treat you more effectively. You may join if you have certain types of severe heart valve problems.
Nantes, Loire AtlantiqueAges 18 years+ - NCT07515508Recruiting
Understanding heart failure patterns in hospitalized patients
This study investigates different types of acute heart failure in hospitalized patients to better understand their condition and improve treatment. Researchers will use multiple imaging and testing methods to create a detailed picture of each patient's heart failure.
Bad KrozingenAges 18 years+ - NCT05553886RecruitingPhase 3
Tablets for chronic heart failure with low pumping strength
This Phase 3 study tests whether S086 tablets can improve treatment for people with chronic heart failure where the heart pumps weakly. You may be eligible if your heart failure symptoms are moderate to severe and your condition is stable on current medicines, but not if you’ve recently had certain heart events or can’t take related blood-pressure/heart drugs.
Shenzhen, GuangdongAges 18 years+ - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Fairhope, AlabamaAges 18 years+ - NCT07693049Recruiting
Exercise training for heart failure with preserved pumping ability
This trial tests whether high-intensity interval training can improve heart function and fitness in people with a type of heart failure where the heart pumps normally but doesn't fill properly. You will do supervised exercise sessions to see if it helps you feel better and be more active.
BeijingAges 35–70 - NCT07592494Recruiting
Arm Exercise Training for Heart Failure With Device
This study compares different types of arm exercises for people with heart failure who have a pacemaker or defibrillator implanted. The goal is to see which exercise approach best improves how well your arms function and help you stay active.
ÇorumAges 18 years+ - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT07420088Recruiting
Seasonal activity in heart failure with a heart device
This trial studies how physical activity changes with the seasons in people with heart failure who have a pacemaker or defibrillator. It aims to help doctors understand how to better support your activity levels throughout the year.
ÇorumAges 18 years+ - NCT07365501Enrolling by invitation
Blood pressure cuff therapy for heart failure patients
This trial tests if a simple, non-invasive blood pressure cuff procedure can improve blood vessel health in people with possible heart failure. It is an early, single-session study to see how the body responds.
Cuenca, CuencaAges 18 years+ - NCT07281040Recruiting
Online discussion about heart failure treatment experiences
This study brings together people who have recently been in the hospital for heart failure and their caregivers to talk in small online groups about their experiences. The goal is to help doctors learn what matters most to patients and to plan better research on heart failure treatments.
Hull, YorkshireAges 18 years+ - NCT06461962Recruiting
Peer support for meth-related heart screening
This study tests whether a peer support program can help people who use methamphetamine get screened for early heart damage. It aims to connect you with care if screening shows possible heart strain.
Portland, OregonAges 18 years+ - NCT07234565Recruiting
Improving social frailty through interactive learning
This trial tests a social program delivered over WeChat to help older adults with heart failure who feel socially frail. It aims to improve social connections and reduce frailty through interactive learning.
ShanghaiAges 60 years+ - NCT06560762RecruitingPhase 1
Study of a new drug for heart failure with preserved pumping ability
This trial tests an investigational drug for people with a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug can improve symptoms and quality of life.
Chicago, IllinoisAges 18 years+ - NCT07202000RecruitingPhase 2
Exercise and a drug to reduce inflammation for heart failure with preserved ejection fraction
This trial tests whether combining exercise with a medication that blocks a protein called activin can reduce inflammation, improve heart function, and help with thinking in people with heart failure with preserved ejection fraction (HFpEF).
Boston, MassachusettsAges 40 years+ - NCT07164911Recruiting
Heart failure rehab: who benefits most?
This study looks at what helps people with heart failure get the most out of a cardiac rehab program. It aims to find out which patients improve the most after completing phase II cardiac rehab.
CorbieAges 40–75 - NCT06670001Recruiting
Increasing daily steps in heart failure with preserved ejection fraction
This study tests if simple rewards and reminders on a smartphone can help people with a certain type of heart failure (HFpEF) become more physically active. The goal is to see if increasing daily steps improves their health and well-being.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06055452RecruitingPhase 4
SGLT2 Inhibitors for Pre-Heart Failure with Hypertension
This trial tests if a medicine (SGLT2 inhibitor) given to people with high blood pressure and early signs of heart stress can help prevent heart failure. You may join if your blood pressure is controlled but tests show your heart is beginning to struggle.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05996328Recruiting
Healthy meals for veterans with heart failure
This study tests whether providing healthy meals to veterans recently hospitalized for heart failure can improve their health and reduce the chance of going back to the hospital. Participants will receive meals at home for a period of time.
Birmingham, AlabamaAges 60 years+ - NCT04982419RecruitingPhase 2/Phase 3
Remote arm treatment to protect heart and kidneys in heart failure
This trial tests whether a simple “arm cuff” treatment done before a heart artery procedure can help protect the kidneys and the heart in people with congestive heart failure. If it works, it may lower the chance of kidney injury around the time of the scan/stent procedure.
Pittsburgh, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 949 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.