Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 949 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06517186Recruiting
Heart failure study with preserved pumping function
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
Chicago, IllinoisAges 30 years+ - NCT06526988Recruiting
Heart failure medication optimization study for clinicians and patients
This study tests tools to help doctors and patients work together to start or adjust heart failure medicines. You may qualify if your heart's pumping strength is low and you are missing certain recommended medications.
Walnut Creek, CaliforniaAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT05029570Recruiting
Heart rate control for permanent atrial fibrillation and heart failure
This trial studies whether a strategy to regularize (control) heart rate can improve outcomes in people who have permanent atrial fibrillation and heart failure. It focuses on people with recent heart-failure hospitalization and checks several heart, kidney, and health-condition limits to keep the study safe.
Madrid, MadridAges 18 years+ - NCT06469814Enrolling by invitation
Heart failure snapshot study
This study is a snapshot of patients with heart failure and aims to better understand how heart failure is managed in different settings, from outpatient care to emergency treatment.
YerevanAges 18 years+ - NCT04950218Recruiting
Study risks of heart problems in people with psoriasis
This study asks adults with psoriasis about factors that may be linked to heart problems. It aims to better understand who is at higher risk, which could help guide future prevention and care.
Hellerup, CopenhagneAges 18 years+ - NCT06423599RecruitingPhase 2/Phase 3
Weight Loss for Obesity and Heart Failure
This study tests whether weight loss from a medication can improve how you feel, move, and how well your heart works. It's for people who have both obesity and heart failure with reduced pumping strength.
CopenhagenAges 18 years+ - NCT06424288RecruitingPhase 3
Testing vicadrostat plus empagliflozin for heart failure
This study tests whether adding a new study drug called vicadrostat to the standard heart failure medicine empagliflozin helps people with heart failure. It may be a good option if you have heart failure with preserved pumping function and are not already on a medicine called an MRA.
Mobile, AlabamaAges 18 years+ - NCT06361524Enrolling by invitation
Gut bacteria study in chronic heart failure
This study looks at the bacteria in your gut (your 'gut microbiome') and how it relates to chronic heart failure. It may help doctors understand why some people with heart failure do better than others and could lead to better treatments in the future.
Stanford, CaliforniaAges 18–75 - NCT06349941RecruitingPhase 3
Heart failure rehab from home using video visits
This study tests whether a home-based cardiac rehab program using video visits and a smartphone app can help people with heart failure recover and feel better. It may be a good option if you have been hospitalized for heart failure recently and want to take part in rehab from home.
Dallas, TexasAges 18 years+ - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Birmingham, AlabamaAges 18–100 - NCT06299176Enrolling by invitationPhase 1
Whole-heart radiation therapy for advanced heart failure
This trial tests if a low dose of radiation to the whole heart can help people with very advanced heart failure. It is for people who have severe symptoms despite maximum medications and are not candidates for a heart pump or transplant.
Montreal, QuebecAges 65 years+ - NCT06299436Recruiting
Heart muscle function testing in right heart failure
This trial studies how the right side of the heart works in people with heart failure. It uses special monitoring to understand muscle function and may help doctors find better ways to treat right heart failure.
Baltimore, MarylandAges 18–90 - NCT05873543Recruiting
Smartphone-based exercise program for heart failure recovery
This trial tests whether a hybrid heart-rehabilitation program that uses a smartphone helps people with heart failure feel better and safely exercise. If you’re eligible, you’ll likely get guided exercise training with help from a phone app.
TaipeiAges 18–80 - NCT06258447Recruiting
CardiAMP bone marrow cell therapy for heart failure
This trial tests a new treatment using your own bone marrow cells to help your heart pump better. It's for people with heart failure after a heart attack whose heart function is moderately reduced.
Clearwater, FloridaAges 21–90 - NCT06222762Recruiting
Personalized exercise follow-up for chronic heart failure
This study tests whether a personalized exercise program can help people with chronic heart failure feel better and stay active. It is for patients who are already in a cardiac rehab program and have stable heart failure.
BrestAges 18–80 - NCT05650658Recruiting
Compare two heart pacing options in people with weak heart function
This trial compares two types of “left-side” heart pacing to see which one works better in people with weak heart pumping. It may help guide the best pacing choice for improving heart function and symptoms.
Gilbert, ArizonaAges 18 years+ - NCT04983823Recruiting
Study aims to improve long-term heart effects after COVID
This trial looks at how persistent heart-related changes after a past COVID infection may be affected by study treatments. It mainly seeks people who are stable enough for follow-up visits and heart imaging, and who are not already on the specific heart medications required.
Melbourne, VictoriaAges 50–85 - NCT06205225Recruiting
Mobile health program for heart failure self-care
This study tests a mobile health program (phone app and coaching) to help people with heart failure better manage their condition at home. It aims to improve self-care and reduce hospital visits.
Chicago, IllinoisAges 18 years+ - NCT06176131Recruiting
Telemedicine support for heart failure after hospital
This study tests a care program that uses telemedicine to help people with serious heart failure stay stable after leaving the hospital. It focuses on those who needed multiple hospital stays recently.
FrederiksbergAges Any age - NCT04438213RecruitingPhase 2
Ertugliflozin for chronic heart failure with added urine testing
This Phase 2 trial studies whether the medication ertugliflozin can help people with chronic heart failure. You would be asked to follow a set treatment plan and complete repeated urine (and other) testing to see how your body responds.
New Haven, ConnecticutAges 18 years+ - NCT06149195Enrolling by invitation
Heart scan for managing heart failure
This trial tests a special heart scan (18F-MFBG) to see if it can help doctors better manage heart failure. You may qualify if you have chronic heart failure with a weak heart pump and are planning to get a defibrillator.
Chengdu, SichuanAges 18–80 - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06065761Enrolling by invitation
Better risk assessment for heart failure in the ER
This trial looks at ways to better understand how serious heart failure is for people who come to the emergency room. It could help doctors decide on the best treatment more quickly.
Antioch, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 949 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.