Clinical trials
Insulin Resistance clinical trials
Below are recruiting insulin resistance clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03818178Recruiting
Study of gut-delivered fats and insulin resistance
This study looks at how sending certain fats through the intestine affects “insulin resistance,” a condition where the body doesn’t use insulin as well. If you qualify, you may receive a controlled lipid (fat) delivery as part of measuring body fat handling and related body chemistry.
Rochester, MinnesotaAges 18–55 - NCT06167135Recruiting
PCOS, Insulin Resistance, and Fertility Study
This study looks at how polycystic ovary syndrome (PCOS) and insulin resistance (a condition where your body doesn't use insulin well) are linked to energy problems in cells (mitochondrial dysfunction). It aims to understand how these conditions affect fertility in women.
BudapestAges 20–45 - NCT07226128Recruiting
Can therapy help HIV patients with depression and insulin resistance?
This study tests if cognitive behavioral therapy (a type of talk therapy) can improve how your body handles sugar (insulin resistance) for people living with HIV who also have depression. You may join if you have HIV, are on stable HIV meds, feel depressed, and do not have diabetes.
Indianapolis, IndianaAges 18 years+ - NCT04250493Recruiting
Testing insulin resistance in multiple system atrophy
This study looks at how the body handles blood sugar (insulin resistance) in people with multiple system atrophy (MSA). Results may help doctors understand the disease better and explore new ways to monitor or treat it.
BordeauxAges 30 years+ - NCT07551947Enrolling by invitation
Insulin Resistance and Heart Rhythm Ablation Success
This study examines whether how your body handles insulin (a hormone that controls blood sugar) affects the success of a new ablation procedure called pulsed field ablation, which treats irregular heart rhythms. Researchers want to understand which patients benefit most from this treatment.
TřinecAges 18 years+ - NCT05470504RecruitingPhase 2
Pegvisomant for severe insulin resistance from rare fat or gene problems
This Phase 2 study tests pegvisomant, a medicine that blocks growth hormone, to see if it can improve severe insulin resistance in people with a specific genetic cause or a rare fat distribution condition. If you fit the rare diagnosis, the study may help clarify whether growth-hormone blocking can improve blood sugar and related health markers.
Bethesda, MarylandAges 18–70 - NCT06487832Recruiting
Effect of diabetes drug on brain response to insulin
This study tests whether a GLP-1 receptor agonist (a type of diabetes medicine) changes how the brain responds to insulin in people with different body sizes. It may help understand if this drug can improve brain function related to insulin.
TübingenAges 18–70 - NCT06039787Recruiting
Exercise and Brain Insulin Sensitivity Study
This study checks if exercise training changes how your brain responds to insulin. You will do ergometer (stationary bike) training, and your brain activity will be measured before and after. It's for people who are not very active now and want to see how exercise affects brain metabolism.
TübingenAges 20–65 - NCT07359625Recruiting
Study on ketone drinks and insulin health
This study tests if drinking a ketone supplement can improve how your body responds to insulin, which affects blood sugar control.
Aarhus NAges 55–70 - NCT05806801Recruiting
Study how weight loss changes the body with or without exercise
This study looks at how your metabolism (how your body uses energy and controls blood sugar/fats) changes during weight loss, comparing weight loss alone versus weight loss plus exercise. It may help researchers understand what body changes happen with different approaches and why.
Ann Arbor, MichiganAges 18–40 - NCT07224334RecruitingPhase 1
How cells talk to adjust insulin for weight
This study looks at how cells in the pancreas communicate to help the body produce enough insulin when you have insulin resistance (weight-related). It tests a peptide to see how this communication works.
Durham, North CarolinaAges 18–60 - NCT05933707Recruiting
Study tiny vesicles and how they affect insulin
This study looks at how very small particles in the body (“extracellular vesicles”) relate to insulin action and how the body handles sugar. It may help researchers understand why some people have better or worse insulin responses.
St Louis, MissouriAges 25–55 - NCT03407833Enrolling by invitation
Study changes in the body after weight, gut, or liver treatment
This study looks at how the body’s insulin-sensitivity (how well your body uses sugar/insulin) and organ function change after certain medical procedures. It may help researchers understand why some people improve after surgery or liver transplant and guide future care.
Nashville, TennesseeAges 18 years+ - NCT07403604RecruitingPhase 1
Lowering Insulin to Reduce Fat Buildup in the Liver
This study tests if lowering insulin levels can reduce fat buildup in the liver for people with a fatty liver condition called MASLD. It's looking for adults who are overweight and have early signs of insulin resistance but not diabetes.
New York, New YorkAges 18–65 - NCT07255807Recruiting
Understanding insulin resistance in healthy adults
This study will look at how insulin resistance works in the body by studying healthy adults. You may help researchers find new ways to understand and treat conditions like diabetes.
CopenhagenAges 25–55 - NCT06129110Recruiting
Weight loss and muscle fat study for adults aged 18-70
This study looks at how losing weight affects the fat that sits inside your muscles (called intermuscular fat). It might help people with overweight to better understand how weight loss can improve muscle health.
Aurora, ColoradoAges 18–70 - NCT05065372RecruitingPhase 1
Metformin test with automated insulin in teens with type 1
This Phase 1 study tests how adding metformin affects blood flow in the kidneys, insulin sensitivity, and overall heart/metabolic health in young people with type 1 diabetes. It may help researchers understand whether this combo is safe and beneficial alongside automated or pump/shot insulin care.
Aurora, ColoradoAges 12–25 - NCT00001987Recruiting
Understanding genetics of insulin resistance and diabetes
This research study looks at the genes and immune system factors that cause severe insulin resistance—a condition where the body doesn't respond well to insulin. Researchers want to understand why some people develop this problem and study family members and healthy volunteers to learn more.
Bethesda, MarylandAges 6 months–120 years - NCT06722391Recruiting
Electrical stimulation to improve metabolism in overweight adults
This study tests whether a non-invasive electrical stimulation treatment can help improve metabolism in people who are overweight and inactive. It may be an option for those who do not exercise regularly.
El Paso, TexasAges 18–65 - NCT03947697Recruiting
Electrical stimulation to help improve blood sugar control
This study tests whether electrical stimulation can improve blood sugar control in people who are overweight and not very active. It’s designed for people with low exercise habits and will compare how your blood sugar responds to the intervention.
El Paso, TexasAges 18 years+ - NCT07505745RecruitingPhase 2
A study on MOTS-c for improving insulin sensitivity
This trial tests an investigational peptide (MOTS-c) to see if it can improve how your body uses insulin. It's for adults with prediabetes and excess weight who are not yet on diabetes medications and can maintain a stable diet and activity level for 12 weeks.
Shenzhen, GuangdongAges 18–65 - NCT05950282Recruiting
Study of insulin sensitivity differences by age and PCOS status
This study looks at how well the body uses insulin (insulin sensitivity) across different ages, sexes, races, body weights, and whether someone has PCOS. It may help researchers understand why insulin function varies and how PCOS could be linked to metabolic health.
Houston, TexasAges 18 years+ - NCT07682077Recruiting
Kefir drink to prevent diabetes in pregnancy
This study tests whether a daily probiotic drink (kefir) during pregnancy can help prevent gestational diabetes. It's for pregnant people who are less than 14 weeks along and live near Fredericton, New Brunswick.
Fredericton, New BrunswickAges 19 years+ - NCT07440147Recruiting
Akkermansia and Berberine for night shift workers' insulin sensitivity
This trial tests whether taking a probiotic called Akkermansia muciniphila and a natural plant compound called berberine can improve how your body uses insulin. If you work night shifts regularly, this study may help you find a way to support your metabolic health.
Graz, StyriaAges 21 years+
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Common questions
- Are there clinical trials for insulin resistance?
- Yes. Clin2 currently lists 125 recruiting insulin resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a insulin resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a insulin resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.