Clinical trials
Insulin Sensitivity clinical trials
Below are recruiting insulin sensitivity clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05233722Recruiting
Study of how mTOR affects insulin sensitivity in healthy men
This study looks at whether a body pathway called mTOR helps control how your body handles insulin and blood sugar. It’s done in healthy men to understand insulin sensitivity before testing approaches in people with health problems later.
CopenhagenAges 22–35 - NCT06776094Recruiting
Exercise and insulin sensitivity study in healthy men
This trial looks at how physical activity affects how your body responds to insulin in healthy men aged 22-35. If you are a non-smoking man with a BMI between 28 and 35 and a certain fitness level, you may be eligible.
CopenhagenAges 22–35 - NCT07265323Recruiting
Testing insulin effects on brain function
This study looks at how giving insulin in a way that mimics the body's natural release can affect thinking and memory. It may help understand how insulin relates to brain health.
Baton Rouge, LouisianaAges 18 years+ - NCT06138821Recruiting
Endoscopic sleeve gastroplasty for obesity and MASH
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
Boston, MassachusettsAges 18 years+ - NCT06216665Recruiting
Pulse hormone effects on insulin
This trial is only for people who completed a previous study called Motivate and had their final insulin test. It tests how giving hormones in pulses affects how your body uses insulin.
Baton Rouge, LouisianaAges 50–75 - NCT04708535Enrolling by invitation
Study how fat changes affect insulin resistance after bariatric surgery
This study looks at how your body’s fat under the skin and inside the abdomen may affect “insulin resistance,” a common problem linked with blood sugar control. It’s for people who are scheduled for bariatric (weight-loss) surgery, to learn more before and after surgery.
Stanford, CaliforniaAges 30–65 - NCT06487832Recruiting
Effect of diabetes drug on brain response to insulin
This study tests whether a GLP-1 receptor agonist (a type of diabetes medicine) changes how the brain responds to insulin in people with different body sizes. It may help understand if this drug can improve brain function related to insulin.
TübingenAges 18–70 - NCT05065372RecruitingPhase 1
Metformin test with automated insulin in teens with type 1
This Phase 1 study tests how adding metformin affects blood flow in the kidneys, insulin sensitivity, and overall heart/metabolic health in young people with type 1 diabetes. It may help researchers understand whether this combo is safe and beneficial alongside automated or pump/shot insulin care.
Aurora, ColoradoAges 12–25 - NCT06550115Recruiting
Night shift workers and their blood vessel & sugar health
This trial studies how sleep patterns affect blood vessel health and sugar control in long-term night shift workers. It may help find better ways to prevent heart problems and diabetes.
Fort Collins, ColoradoAges 18–65 - NCT07247734RecruitingPhase 2
Colchicine for insulin sensitivity in type 1 diabetes
This trial tests whether a daily oral medication called colchicine can improve how your body responds to insulin. It is for people with type 1 diabetes who have ongoing low-level inflammation and are already using a continuous glucose monitor.
Gentofte MunicipalityAges 18–80 - NCT05806801Recruiting
Study how weight loss changes the body with or without exercise
This study looks at how your metabolism (how your body uses energy and controls blood sugar/fats) changes during weight loss, comparing weight loss alone versus weight loss plus exercise. It may help researchers understand what body changes happen with different approaches and why.
Ann Arbor, MichiganAges 18–40 - NCT07359625Recruiting
Study on ketone drinks and insulin health
This study tests if drinking a ketone supplement can improve how your body responds to insulin, which affects blood sugar control.
Aarhus NAges 55–70 - NCT06061926RecruitingPhase 2
Celery seed for metabolic syndrome
This trial tests whether celery seed can improve the key features of metabolic syndrome, such as blood sugar, cholesterol, and blood pressure. It may help people whose condition is not yet being treated with medication.
Guadalajara, JaliscoAges 30–60 - NCT05833217Recruiting
Study for persistent COVID symptoms with insulin resistance
This trial studies people who have ongoing effects after COVID (often called PASC) and may be related to weight and insulin resistance. It may help researchers find better ways to understand the condition and improve treatment.
Palo Alto, CaliforniaAges 18–80 - NCT03407833Enrolling by invitation
Study changes in the body after weight, gut, or liver treatment
This study looks at how the body’s insulin-sensitivity (how well your body uses sugar/insulin) and organ function change after certain medical procedures. It may help researchers understand why some people improve after surgery or liver transplant and guide future care.
Nashville, TennesseeAges 18 years+ - NCT05010356Recruiting
Testing insulin sensitivity after breast cancer treatment
This study looks at how well your body uses insulin (a hormone that helps move sugar from the blood into cells) after breast cancer treatment. It may help researchers understand whether insulin sensitivity changes after chemotherapy and could guide future health monitoring.
Copenhagen, DKAges 20–45 - NCT06129110Recruiting
Weight loss and muscle fat study for adults aged 18-70
This study looks at how losing weight affects the fat that sits inside your muscles (called intermuscular fat). It might help people with overweight to better understand how weight loss can improve muscle health.
Aurora, ColoradoAges 18–70 - NCT07109245RecruitingPhase 4
Do antipsychotics block insulin action in the brain?
This study tests whether a single dose of a common antipsychotic medication affects how the brain responds to insulin, which could help explain weight gain and metabolic side effects. Healthy young adults will receive either the antipsychotic or a placebo, then have their brain activity measured with an MRI.
Toronto, OntarioAges 18–35 - NCT07505745RecruitingPhase 2
A study on MOTS-c for improving insulin sensitivity
This trial tests an investigational peptide (MOTS-c) to see if it can improve how your body uses insulin. It's for adults with prediabetes and excess weight who are not yet on diabetes medications and can maintain a stable diet and activity level for 12 weeks.
Shenzhen, GuangdongAges 18–65 - NCT05950282Recruiting
Study of insulin sensitivity differences by age and PCOS status
This study looks at how well the body uses insulin (insulin sensitivity) across different ages, sexes, races, body weights, and whether someone has PCOS. It may help researchers understand why insulin function varies and how PCOS could be linked to metabolic health.
Houston, TexasAges 18 years+ - NCT07516509Recruiting
How muscle cells respond to blood sugar in different body types
This research study examines how muscle cells handle blood sugar differently depending on whether someone is lean or has obesity, and whether their body resists insulin. Researchers will take small muscle samples to understand the genetic differences, which may help develop better treatments for insulin resistance and metabolic health.
Orlando, FloridaAges 30–65 - NCT06366399Recruiting
Timing of resistance exercise for weight management
This study tests if doing resistance exercises (like lifting weights) in the morning or afternoon is better for weight management. You may qualify if you are between 50 and 74 years old, are overweight but generally healthy, and have not been very active with strength training.
Salt Lake City, UtahAges 50–74 - NCT06688461Recruiting
Exercise study to improve blood sugar in type 2 diabetes
This study tests whether high-intensity interval training can improve how your body uses insulin. It is for people with type 2 diabetes who are not on insulin and have had diabetes for 1 to 5 years.
SantiagoAges 45–75 - NCT07440147Recruiting
Akkermansia and Berberine for night shift workers' insulin sensitivity
This trial tests whether taking a probiotic called Akkermansia muciniphila and a natural plant compound called berberine can improve how your body uses insulin. If you work night shifts regularly, this study may help you find a way to support your metabolic health.
Graz, StyriaAges 21 years+
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Insulin Sensitivity trials by city
Studies with a site in or near these metro areas.
Insulin Sensitivity trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for insulin sensitivity?
- Yes. Clin2 currently lists 50 recruiting insulin sensitivity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a insulin sensitivity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a insulin sensitivity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.