Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 837 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07601906Recruiting
Blood Flow Exercise Therapy After Knee Replacement Surgery
This study tests whether special exercises that temporarily reduce blood flow to your leg can help you recover better after knee replacement surgery. It focuses on reducing pain and improving your ability to bend and straighten your knee.
Lahore, Punjab ProvinceAges 50–65 - NCT07275983Recruiting
Knee replacement recovery: spinal vs. general anesthesia
This study looks at recovery after total knee replacement surgery. It compares people who had spinal anesthesia (numbing the lower body) to those who had general anesthesia (being fully asleep) to see which group recovers better.
StrasbourgAges 18 years+ - NCT06565377Recruiting
Pre-surgery program for knee replacement patients
This trial tests a program of exercise, education, and support to help you prepare for knee replacement surgery. It aims to improve your recovery and quality of life.
Geel, AntwerpenAges 18 years+ - NCT07092982Recruiting
Comparing two numbing methods for knee replacement surgery
This study compares two different numbing techniques to see which provides better pain control during and after total knee replacement. It may help find a way to reduce pain and improve recovery.
IstanbulAges 18–75 - NCT06847113Recruiting
Walking Speed Before and After Knee Replacement
This study follows people who are getting a knee replacement to see how their walking speed changes over time—both when they walk at their own pace and as fast as they can. It helps doctors understand recovery better.
OsloAges 55 years+ - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT07276061Recruiting
Outpatient vs. in-hospital knee replacement recovery study
This study compares recovery after total knee replacement when patients go home the same day versus staying overnight in the hospital. It aims to see if outpatient surgery leads to similar or better recovery.
StrasbourgAges 18 years+ - NCT06994546Recruiting
ArtiBest injection for knee osteoarthritis pain
This trial tests a new hyaluronic acid injection called ArtiBest for people with mild to moderate knee osteoarthritis who haven't gotten enough relief from other treatments like physical therapy or pain pills. It aims to see if the injection can reduce knee pain and improve function.
Kaohsiung CityAges 35–85 - NCT06953375Recruiting
Electrical stimulation for faster recovery after knee replacement
This study tests if adding a gentle electrical stimulation (called NMES) to standard physical therapy helps people recover strength faster after knee replacement surgery. It is for patients who go to specific UCHealth or Intermountain Health therapy clinics after their first total knee replacement.
Aurora, ColoradoAges 18 years+ - NCT06925880Recruiting
Can creatine help seniors recover strength after knee replacement?
This trial tests if taking creatine supplements can help people aged 65+ rebuild muscle mass and strength more quickly after total knee replacement surgery. Participants will take creatine during their standard outpatient rehab program.
Mataró, BarcelonaAges 65 years+ - NCT06909916Recruiting
Weight-Bearing CT for Knee Fractures Above a Replacement
This study uses a special weight-bearing CT scan to look at how well the bone around a repaired knee fracture heals after a second surgery. If you’ve had surgery for a broken bone above your knee replacement, this scan might help doctors learn more about your recovery.
London, OntarioAges 50–90 - NCT06699134Recruiting
Study on Hi-Fatigue G Bone Cement in Knee or Hip Replacement
This study looks at how well a specific bone cement (Hi-Fatigue G) works in people who have had a knee or hip replacement. It aims to help doctors understand if this cement is a good option for holding the artificial joint in place.
Weiden, BavariaAges 18 years+ - NCT06685120Recruiting
PRP and hyaluronic acid for knee osteoarthritis
This study tests a combination of platelet-rich plasma (PRP) and hyaluronic acid injections for knee osteoarthritis. It aims to see if these injections together can reduce pain and improve function better than standard treatments.
BolognaAges 40–75 - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06616896Recruiting
Vibration exercise for knee osteoarthritis
This study tests whether a special vibrating exercise program can improve knee pain and function in people with knee osteoarthritis. It compares this new rehab approach to standard exercise.
TaipeiAges 50–80 - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06596031Enrolling by invitation
Health coaching for people waiting for hip or knee replacement
This study tests whether health coaching can help people who are waiting for hip or knee replacement surgery. It aims to improve your health and wellbeing while you wait for your operation.
SheffieldAges 18 years+ - NCT06947655Recruiting
Tourniquet types for knee replacement surgery
This study compares different types of tourniquets (tight cuffs) used during knee replacement surgery to see how they affect blood loss and how satisfied surgeons are with them.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06004882Recruiting
Nerve stimulation vs. steroid injection for chronic knee pain
This study compares two treatments for long-term knee pain: a nerve stimulation device placed near the knee versus a steroid shot into the joint. The goal is to see which works better for pain relief.
Houston, TexasAges 18 years+ - NCT07727551Recruiting
Nerve block before knee replacement for better recovery
This trial tests if a nerve block given a few weeks before knee replacement surgery can improve pain and function after the operation. It is designed for people who have certain risk factors that might make recovery harder.
BrusselsAges 18–60 - NCT07468734Recruiting
Shock wave vs. physical therapy for knee arthritis
This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and traditional physical therapy. The goal is to see which one helps reduce pain and improve function better.
CairoAges 40 years+ - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT06182397Recruiting
Drug-coated balloon for leg artery blockages below the knee
This trial tests a special balloon coated with sirolimus (a drug that helps prevent arteries from re-closing) versus a standard balloon for opening blocked arteries below the knee in people with severe leg pain or foot wounds. The goal is to see if the drug-coated balloon works better to keep the artery open longer.
Scottsdale, ArizonaAges 21 years+ - NCT07356674Recruiting
Surgery for Meniscus Tear with Mild Bow Legs
This trial tests a new surgical approach for a specific type of meniscus tear (the cartilage that cushions the knee) in people who have a mild bow-legged (varus) knee. It combines a small bone cut near the knee with arthroscopic repair to fix the tear.
Shenzhen, GuangdongAges 35–75
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 837 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.