Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07551245Recruiting
High-intensity laser vs traditional treatment for knee osteoarthritis
This study tests whether high-intensity laser therapy works better than traditional physical therapy methods for knee osteoarthritis pain and function. You'll be randomly assigned to receive either laser treatments or standard rehabilitation exercises.
Erbil, Erbil GovernorateAges 30–60 - NCT07547735RecruitingPhase 2
Stem Cell Treatment for Knee Osteoarthritis
This study tests whether special stem cells (called UC-MSCs, derived from umbilical cord tissue) can reduce pain and improve function in people with moderate knee osteoarthritis. Researchers will inject these cells into your knee to see if they help repair damaged cartilage and reduce inflammation.
WuhanAges 40–70 - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85 - NCT07539467Enrolling by invitation
Nerve Block and Tourniquet for Knee Surgery Pain Relief
This trial tests whether a nerve block (numbing injection near the thigh) combined with a tourniquet (pressure cuff) after knee replacement surgery reduces pain better than standard care. If it works, it could help patients recover more comfortably with less need for strong pain medications.
AnkaraAges 40–85 - NCT07542808RecruitingPhase 2/Phase 3
Stem cell treatment vs. hyaluronic acid for knee arthritis
This study tests whether an injection of stem cells (special cells that can help repair tissue) works better than a standard hyaluronic acid injection for knee osteoarthritis pain. Both treatments are injected into the knee to reduce pain and improve function.
Abu DhabiAges 18 years+ - NCT07537153Recruiting
Blocking Blood Vessels to Reduce Knee Arthritis Pain
This trial tests a procedure called genicular artery embolization, which blocks small blood vessels around the knee to reduce pain from moderate arthritis. It may help people whose knee pain hasn't improved with medications.
Chicago, IllinoisAges 40–80 - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT06753019Recruiting
Knee Osteoarthritis: Thoughts, Feelings, and Function
This study looks at how your thoughts and feelings about knee pain (and your daily function) relate to osteoarthritis. It aims to help understand your overall health better.
IspartaAges 40–84 - NCT07522736Recruiting
Spinal anesthesia with dexmedetomidine for knee surgery
This trial tests adding dexmedetomidine (a calming medication) to bupivacaine (numbing medication) injected into the spine during knee surgery. The goal is to improve pain relief and recovery after surgery.
CairoAges 18–65 - NCT06762171Recruiting
Knee arthritis treatment for inner and front knee pain
This trial tests a treatment for people with knee arthritis affecting the inner and front parts of the knee. It aims to help relieve pain and improve function without needing a full knee replacement.
Sohag, Sohag GovernorateAges 35–60 - NCT07513415Recruiting
Injectable knee filler for osteoarthritis pain relief
This trial tests a new injectable filler called ALLOHEAL, injected directly into the knee joint to reduce pain and improve function in people with knee osteoarthritis. The filler is designed to cushion the knee joint and may help reduce pain and stiffness.
Uijeongbu-siAges 40–80 - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Escondido, CaliforniaAges 18 years+ - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07499973Recruiting
Core muscle strength and knee stability for injury prevention
This study looks at how your core (abdominal muscles) affects knee stability. It will test a training program to see if it helps prevent injuries. You will be randomly assigned to either the training group or a control group for 8 weeks.
Villaviciosa de Odón, MadridAges 18–35 - NCT07501013Recruiting
Shoulder and knee surgery outcomes study
This study looks at how well different types of shoulder and knee surgeries work for sports injuries. It aims to help improve future care by following patients' recovery after common procedures like fixing torn cartilage or repairing ligaments.
Hangzhou, ZhejiangAges 8–80 - NCT07507175Recruiting
Calf muscle release for women with knee arthritis
This trial tests whether releasing tight calf muscles can help women with knee osteoarthritis feel less pain. It focuses on women who have moderate knee arthritis and a tight spot in their calf muscle.
Giza, Giza GovernorateAges 45–55 - NCT07496203Recruiting
BETY program after knee injections for osteoarthritis
This trial tests if a special exercise and education program called BETY helps people with knee osteoarthritis feel better after getting a knee injection. You may qualify if you had a knee injection in the last month and have moderate knee arthritis.
Ankara, SamanpazarıAges 18 years+ - NCT06773676Recruiting
Home laser device study for knee osteoarthritis relief
This study tests whether using a laser device at home can help reduce knee pain and improve function in people with knee osteoarthritis. You would use the device yourself over several weeks to see if it eases your symptoms.
Ashkelon, Southern DistrictAges 50–90 - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT07481461Recruiting
Knee alignment and biology in osteoarthritis
This study looks at how changes in knee alignment affect symptoms and joint biology in people with early knee osteoarthritis. It may help doctors understand how to better treat knee OA.
Leuven, Vlaams-BrabantAges 18 years+ - NCT07489521RecruitingPhase 4
Arthrosamid vs. steroid for knee arthritis pain
This trial compares a new injection called Arthrosamid with a standard steroid injection to see which works better for knee arthritis pain over time. It may help you if you have knee arthritis and have not had recent injections or knee surgery.
Dublin, DublinAges 18–100 - NCT07484529Recruiting
Water vs land exercises for knee osteoarthritis
This study compares two types of physical therapy exercises — one done in water and one done on land — to see which is better for reducing pain and improving movement in people with knee osteoarthritis.
RawalpindiAges 40–65 - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75 - NCT07484594Recruiting
Trunk stabilization plus knee rehab for knee-spine syndrome
This trial tests whether adding trunk stabilization exercises to standard knee osteoarthritis rehab can improve outcomes for people with both knee pain and low back pain. It may help if you have moderate knee arthritis and have had back pain for at least 3 months.
Islamabad, ALAges 40–60
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.