Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 837 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06733597Recruiting
Bone density change after knee replacement with or without cement
This study looks at how bone density in the thigh bone changes after knee replacement surgery, comparing two ways of attaching the new joint (with cement or without). It may help people who have normal bone density or early bone thinning but not full osteoporosis.
Madison, WisconsinAges 55 years+ - NCT06120023Recruiting
Long-term follow-up of the Madison knee replacement system
This study follows patients in France who receive a Madison total knee replacement. It watches how well the knee works and how the patient feels over time, to make sure the implant is safe and effective.
Lyon, RhôneAges 18 years+ - NCT06387459Recruiting
Fabric knee brace for better walking in older adults
This study tests a soft, fabric knee brace designed to help older adults walk better. If you are 65 or older and have muscle weakness, diabetes-related foot numbness, or knee arthritis, this brace may improve your balance and stability.
Seoul, JongnoAges 65 years+ - NCT05288803Recruiting
Personalized rehab plans for veterans after knee replacement
This study tests whether customizing a recovery plan (“trajectory”) can improve rehabilitation for veterans after total knee replacement surgery. You may be eligible if you start outpatient rehab soon after surgery at participating clinics.
Aurora, ColoradoAges 40–90 - NCT07499973Recruiting
Core muscle strength and knee stability for injury prevention
This study looks at how your core (abdominal muscles) affects knee stability. It will test a training program to see if it helps prevent injuries. You will be randomly assigned to either the training group or a control group for 8 weeks.
Villaviciosa de Odón, MadridAges 18–35 - NCT06746168Recruiting
Better pain control after knee replacement surgery
This study tests a new way to manage pain after total knee replacement. It aims to see if a specific local pain block can reduce the need for strong opioids and improve recovery.
Hasselt, LimburgAges 18–85 - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT07695168Recruiting
Digital course and rehab for knee osteoarthritis
This study tests whether a digital program with special sensors and a digital twin can help reduce knee pain and improve mobility in older adults with knee osteoarthritis. It also includes healthy adults for comparison.
TaipeiAges 20–80 - NCT07021287Recruiting
Cold therapy after knee replacement surgery
This study compares different cold therapy programs to see which works best for pain and swelling after total knee replacement. Everyone in the study receives cold therapy, and the researchers will track recovery outcomes.
Yiwu, ZhejiangAges 18 years+ - NCT07509866Recruiting
Comparing pain relief options for knee replacement surgery
This trial tests two different numbing medicines for knee replacement surgery. It compares a long-acting numbing medicine (liposomal bupivacaine) with a standard one (ropivacaine) mixed with other drugs to see which provides better pain control. The goal is to find a way to reduce pain and improve recovery.
Wuhan, HubeiAges 18–80 - NCT06641206Recruiting
Dexmedetomidine injection for chronic knee pain
This trial tests whether a single injection of dexmedetomidine into the knee joint can reduce chronic knee pain. It is for people who are not scheduled for knee surgery and have no serious health problems.
Tanta, El GharbyiaAges 40–75 - NCT06640491RecruitingPhase 1/Phase 2
Antibiotics via bone injection for knee replacement
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Houston, TexasAges 18 years+ - NCT07127042RecruitingPhase 2
Testing a drug to reduce bleeding during knee replacement
This trial tests an experimental drug called BT-114143 to see if it reduces bleeding during and after total knee replacement surgery. It may be a good option for people with osteoarthritis who are having their first knee replacement.
Chengdu, Si'ChuanAges 18–70 - NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT06971757Recruiting
Is yearly check-up after hip or knee replacement needed?
This study looks at whether routine check-ups one year after hip or knee replacement are helpful or unnecessary. If you've had or are scheduled for a first hip or knee replacement for arthritis, you may be able to join.
AmsterdamAges 50 years+ - NCT05020028RecruitingPhase 2/Phase 3
CBD to reduce knee pain from osteoarthritis
This study tests cannabidiol (CBD) to help lower pain from knee osteoarthritis. It may be an option if you have ongoing knee pain and meet age, safety, and medication guidelines.
New York, New YorkAges 40–75 - NCT07366736Recruiting
Cold and compression after knee replacement – a study
This study tests if a cooling and compression device applied to the knee after replacement surgery helps with pain and recovery. It compares the device to standard care in people having their first knee replacement.
ÉchirollesAges 18 years+ - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT05828810Recruiting
Testing antiseptic skin cleaning during hip or knee revision surgery
This study checks whether an antiseptic method for cleaning the skin before surgery is safe and helpful for patients having a repeat (revision) hip or knee replacement. It may help reduce the risk of infection related to surgery.
Barrie, OntarioAges 18 years+ - NCT07336160Recruiting
Nutrition before knee replacement surgery
This trial studies a special nutrition plan before knee replacement surgery to see if it helps recovery. Participants follow enhanced recovery guidelines for eating and drinking before their operation.
Istanbul, IstanbulAges 18 years+ - NCT07329361Recruiting
Frozen platelet-rich plasma injections for knee osteoarthritis
This trial tests whether frozen platelet-rich plasma (PRP) injections into the knee can safely reduce pain and improve function in people with knee osteoarthritis. It's for those with mild to moderate knee arthritis who haven't had certain recent knee treatments.
Vitoria-Gasteiz, Araba/ÁlavaAges 40–85 - NCT06931951Recruiting
Acupuncture with medicine for knee pain after a car accident
This trial tests a type of acupuncture that injects medicine into specific points (pharmacopuncture) to treat severe knee pain from a recent traffic accident. It looks at whether this treatment is safe and effective for people who are already in the hospital for their injury.
DaejeonAges 19–69
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 837 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.