Clinical trials
Mechanical Ventilation clinical trials
Below are recruiting mechanical ventilation clinical trials, each written for real people, not researchers. We’re tracking 266 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04524585Recruiting
Tested a muscle-relaxing treatment for severe low-oxygen breathing
This study tests whether partially relaxing the breathing-related muscles can help people with severe low oxygen while they are on a breathing machine. It may improve how well the lungs work by changing the way the muscles affect breathing.
Toronto, OntarioAges 18 years+ - NCT04530760Recruiting
Study of breathing problems in people with liver scarring on a ventilator
This study looks at whether people with cirrhosis who are on a breathing machine have increased pressure in the belly and small unnoticed breathing mist (microaspiration). It may help doctors better monitor and prevent breathing complications while patients are being mechanically ventilated.
LilleAges 18–99 - NCT04801589RecruitingPhase 3
Guided sedation for children on a breathing machine
This study tests a “goal-directed” approach to sedation (giving the right amount based on target goals) for children who need a breathing machine in the pediatric ICU. The goal is to reduce brain and recovery side effects while keeping children comfortable and safe.
Nashville, TennesseeAges 10 months–11 years - NCT05160987Recruiting
Sedation choice for ICU patients on breathing machines
This study compares two sedation medicines—remimazolam vs midazolam—for very sick ICU patients who are on a breathing machine. It looks at whether one sedative works better or is safer for keeping patients comfortable while they’re critically ill.
Guangzhou, GuangdongAges 18–80 - NCT05207046Recruiting
Study for people on a breathing machine after spine trauma
This trial studies how care is given to people who have a traumatic injury to the spine and need a breathing machine. It may help improve treatment and recovery for people who are ventilated after injury, including those with or without spinal cord damage.
Toronto, OntarioAges 16 years+ - NCT05226247Recruiting
Check whether careful weaning prevents lung fluid buildup
This study looks at people on a breathing machine for more than 48 hours who are starting a “spontaneous breathing trial,” a test used to see if they can breathe on their own. It focuses on those at higher risk of “weaning-induced pulmonary edema,” meaning fluid can collect in the lungs during the weaning process.
DijonAges 18 years+ - NCT05371886Recruiting
Testing how morphine (with or without midazolam) behaves in NICU babies
This study measures how morphine works in very young babies, and whether adding midazolam changes how the medicines behave and affect the body. It may help doctors better choose and dose pain/sedation medicines for babies in intensive care.
BrestAges 5 months–10 months - NCT05534243Recruiting
A breathing and brain-signal study for adults on ventilators
This study looks at brain activity during care for adults who are on a breathing machine through a tube in the windpipe. It may help doctors understand how to monitor recovery and guide care after intubation.
Iowa City, IowaAges 18 years+ - NCT05536531Recruiting
NMES therapy to help prevent ICU muscle weakness
This trial tests whether a device that delivers small electrical pulses to muscles can help prevent breathing and muscle weakness in very sick ICU patients. It also looks at changes in blood markers that may relate to muscle weakness and recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT05562505Recruiting
Using ECMO to help you breathe, sit up, and come off a ventilator
This trial tests whether a heart-lung machine called venovenous ECMO can help people with severe breathing failure get less sedated, get extubated (have the breathing tube removed), and start moving. It’s for certain adults who are on a ventilator for a short time and have specific oxygenation problems.
Darlinghurst, New South WalesAges 18–65 - NCT05668637Recruiting
AI tool to support care decisions for ventilated adults
This study tests an artificial intelligence (AI) software that helps clinicians make care decisions for people who are on a breathing machine. It may help teams respond faster and more consistently when complex breathing support is needed.
Cleveland, OhioAges 18 years+ - NCT05785637Recruiting
Home sleep testing after starting noninvasive breathing support
This study checks breathing/sleep measurements done at home for people who recently started a machine that helps them breathe without an endotracheal tube. It may help the team confirm how well home monitoring works after hospital setup of this breathing support.
GarchesAges 18 years+ - NCT05867472RecruitingPhase 3
Sedation plan for critically ill children on breathing machines
This Phase 3 trial tests a sedation approach using inhaled (“volatile”) anesthesia gases for children who need a ventilator. It aims to improve comfort and brain-related outcomes while they stay on the breathing machine for at least a day.
Hamilton, OntarioAges 1 month–18 years - NCT05990348Recruiting
Comparing two breathing support methods for weaning from ventilator
This study compares two ways of helping patients breathe on a ventilator after a failed attempt to come off the machine. It looks at how the diaphragm and rib muscles work during each method to find the best approach for weaning.
RomeAges 18 years+ - NCT06009731Recruiting
Diaphragm ultrasound during breathing trial
This study uses a special ultrasound technique to look at how your diaphragm (the main breathing muscle) moves while you try breathing on your own. It may help doctors better understand when patients are ready to come off the breathing machine.
AmiensAges 18 years+ - NCT06014138RecruitingPhase 2/Phase 3
Volatile sedation study for ARDS patients
This trial is comparing a new type of inhaled sedative (volatile sedation) to usual IV sedatives for people with ARDS who are on a ventilator in the ICU. It aims to see if it can help patients breathe better and recover more quickly.
London, LondonAges 17 years+ - NCT06117683Recruiting
Testing a new breathing device during planned surgery
This trial compares a new breathing device (used with a hand-held bag) to a standard breathing machine during planned surgeries. Researchers want to see if the new device works just as well for people under general anesthesia.
Providence, Rhode IslandAges 18–80 - NCT06119516Recruiting
Guiding breathing machine settings for severe obesity and lung injury
This study tests a new way of setting the breathing machine for people with severe obesity and lung injury (ARDS). It aims to measure pressure inside the lungs more directly, which could help customize ventilation and improve outcomes.
AngersAges 18 years+ - NCT06148467Recruiting
Understanding breathing patterns and adjusting ventilator support
This study looks at a specific breathing pattern called reverse triggering in people with ARDS (a serious lung condition) who are on a ventilator. The goal is to see how adjusting the ventilator settings affects this pattern and improves breathing coordination.
GuadalajaraAges 18–90 - NCT06168162Recruiting
Personalized breathing support during weight-loss surgery
This trial tests whether a personalized breathing setting during surgery can lower the risk of lung complications after weight-loss surgery. If you have a high risk of lung issues, you may be eligible.
Cairo, Cairo GovernorateAges 16 years+ - NCT06184945Recruiting
Study of ICU staffing and support strategies
This study looks at how different staffing and support strategies may help patients who need a breathing machine in the ICU. Researchers want to see if these approaches can improve care and recovery.
Iowa City, IowaAges 19 years+ - NCT06189924Recruiting
Breath analysis in ventilated ICU patients
This study collects and analyzes the moisture you breathe out while on a ventilator in the ICU. It aims to learn more about your condition by examining your breath.
OlomoucAges 18 years+ - NCT06692400Recruiting
Suctioning, pain, and blood markers in intubated patients
This study looks at how routine suctioning of the breathing tube affects pain levels and certain substances in the blood in adults who are on a breathing machine for serious infections like flu, pneumonia, COVID, or sepsis. It may help doctors better understand and manage your comfort during this procedure.
Loma Linda, CaliforniaAges 18 years+ - NCT06330610Recruiting
Intermittent tube feeding for organ failure in the ICU
This trial tests if giving tube feeding at certain times of day, instead of continuously, helps people on breathing machines recover from organ failure faster. It is for patients who need a breathing tube and are receiving medicine to support their blood pressure.
Rouen, FranceAges 18 years+
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Common questions
- Are there clinical trials for mechanical ventilation?
- Yes. Clin2 currently lists 266 recruiting mechanical ventilation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mechanical ventilation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mechanical ventilation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Mechanical Ventilation Complication
- Mechanical Ventilation Weaning
- Invasive Mechanical Ventilation
- Mechanical Ventilation Pressure High
- Prolonged Mechanical Ventilation
- Weaning Failure of Mechanical Ventilation
- Weaning Invasive Mechanical Ventilation
- Respiratory Insufficiency Requiring Mechanical Ventilation
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.