Clinical trials
Muscle clinical trials
Below are recruiting muscle clinical trials, each written for real people, not researchers. We’re tracking 1,109 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06571708RecruitingPhase 2
Chemo plus immunotherapy for muscle-invasive bladder cancer
This trial tests adding two immunotherapy drugs (cemiplimab and fianlimab) to standard chemotherapy (gemcitabine and cisplatin) for people with bladder cancer that has grown into the muscle layer but hasn't spread. The goal is to see if adding these immunotherapies helps shrink the tumor before surgery.
New York, New YorkAges 18 years+ - NCT06545955RecruitingPhase 3
Gene therapy study for high-grade bladder cancer not responding to BCG
This trial tests a gene therapy called nadofaragene firadenovec, given directly into the bladder, either alone or with chemo or immunotherapy. It's for people with high-grade bladder cancer that hasn't gone away after BCG treatment.
Tucson, ArizonaAges 18 years+ - NCT06532123Recruiting
Study on improving muscle control for bowel leakage
This trial tests a treatment to strengthen the muscles that control bowel movements in people with weak anal sphincters. It may help those who have trouble holding in stool or gas.
Milwaukee, WisconsinAges 18 years+ - NCT06537960Recruiting
Later scan images to better see bladder cancer spread
This trial tests whether taking extra, later images during your standard FDG PET-CT scan can give doctors a better view of how far your muscle-invasive bladder cancer has spread. You may be eligible if you are 18 or older, have confirmed muscle-invasive bladder cancer, and are already getting this type of scan.
Suresnes, Île-de-France RegionAges 18 years+ - NCT06521502Recruiting
Studying inflammation in the heart and lungs in the ICU
This study collects blood samples from people in the ICU with sudden heart or lung problems caused by inflammation. The goal is to learn more about these conditions and improve future treatments.
Fresno, CaliforniaAges 18 years+ - NCT06510231Recruiting
Breathing muscle training for heart failure with preserved ejection fraction
This study tests whether breathing muscle training can improve exercise capacity and symptoms in people with a type of heart failure called HFpEF. You may qualify if you are already on certain heart medications and are stable enough to exercise.
Rochester, MinnesotaAges 18 years+ - NCT06511648RecruitingPhase 2
Erdafitinib with or without immunotherapy for FGFR-altered bladder cancer
This trial tests a targeted therapy called erdafitinib, either alone or combined with an immunotherapy drug (cetrelimab), for people with muscle-invasive bladder cancer that has a specific FGFR gene change. It may be an option if you cannot take cisplatin chemotherapy and have not had prior treatment for this cancer.
Clermont-FerrandAges 18 years+ - NCT06470282RecruitingPhase 1/Phase 2
Drug combo plus radiation for muscle-invasive bladder cancer
This trial tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with bladder cancer that has grown into the muscle layer. The goal is to see if this treatment can kill the cancer while avoiding the need for bladder removal surgery.
San Francisco, CaliforniaAges 18 years+ - NCT06469346Enrolling by invitation
Eccentric Exercise vs. Stretching for Hamstring Flexibility
This study compares two ways to improve hamstring flexibility in men who are not very active: eccentric (lengthening) exercises vs. static stretching. If you have tight hamstrings and are a healthy university student, this trial may help you find which method works better.
Temuco, CautínAges 18–35 - NCT06471751Recruiting
Breathing and throat muscle exercises for moderate sleep apnea
This trial tests whether strengthening your breathing and throat muscles can improve moderate sleep apnea. It aims to see if these exercises help reduce breathing pauses and improve sleep quality.
GrenobleAges 18 years+ - NCT06351904RecruitingPhase 1
Testing RAG-01 for bladder cancer that returned after BCG treatment
This trial tests a new drug, RAG-01, for people with a type of bladder cancer called non-muscle-invasive bladder cancer (NMIBC) that has come back after BCG therapy. The drug is given through a catheter into the bladder, and the study aims to see if it can help control the cancer.
St Leonards, New South WalesAges 18–75 - NCT06280482RecruitingPhase 1
Nicotinamide Riboside for Moyamoya in Smooth Muscle Dysfunction
This trial tests a vitamin B3 supplement called nicotinamide riboside (NR) to see if it can help people with Smooth Muscle Dysfunction Syndrome (SMDS) who have a specific gene mutation. The goal is to improve blood flow problems in the brain (moyamoya-like disease) caused by the condition.
Houston, TexasAges 1 year+ - NCT06007794Recruiting
Muscle health study for post-cancer patients
This study uses ultrasound to measure thigh muscle mass and compares it to a whole-body scan. It aims to understand muscle changes after cancer treatment.
Pierre-BéniteAges 18–74 - NCT06417190RecruitingPhase 2
Bladder preservation trial for muscle-invasive bladder cancer with variant histology
This trial tests a bladder-sparing approach for people with muscle-invasive bladder cancer that has a variant histology type. The goal is to avoid removing the bladder by using a combination of treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06411041Enrolling by invitation
Pelvic floor training plus yoga for breast cancer survivors
This study looks at whether a program that combines pelvic floor exercises (like Kegels) with yoga can improve bladder and pelvic health in women who have had breast cancer. It may help with symptoms like leaking urine, pressure, or discomfort.
TaipeiAges 20–60 - NCT06296381Recruiting
Measuring normal muscle strength in ICU patients and healthy people
This study measures normal muscle strength in healthy people and ICU patients to create a reference guide. If you are healthy or in the ICU and can follow instructions, you may be able to help.
Recife, BrazilAges 18–90 - NCT06370832Recruiting
Breathing muscle training for people waiting for a lung transplant
This study tests if a special breathing exercise (inspiratory muscle training) can strengthen your breathing muscles while you wait for a lung transplant. You'd do the training alongside your regular pulmonary rehab sessions.
Edmonton, AlbertaAges 18 years+ - NCT06321965Recruiting
Study of SMA in Children on SMN-Boosting Therapies
This study is looking for children and teens with spinal muscular atrophy (SMA) who are already on a treatment like Spinraza, Evrysdi, or Zolgensma. The goal is to understand different forms of SMA and how the treatment affects them over time.
Bron, RhoneAges birth–16 years - NCT06335667Recruiting
MRI vs. TURBT for muscle-invasive bladder cancer
This study compares two ways to check if bladder cancer has grown into the muscle layer: an MRI scan (mpMRI) versus a standard surgery called TURBT (where a small tool removes a sample of the tumor). The goal is to see if the MRI can be as accurate as the surgery, so future patients might avoid an extra procedure.
Orange, CaliforniaAges 18 years+ - NCT06263153RecruitingPhase 2
Futibatinib and durvalumab before bladder cancer surgery
This trial tests two drugs (futibatinib and durvalumab) given before bladder removal surgery for people with muscle-invasive bladder cancer who cannot take standard cisplatin chemotherapy. The goal is to see if the combination shrinks the tumor and improves outcomes.
Ann Arbor, MichiganAges 18 years+ - NCT06245343Recruiting
Breathing exercise study for lung cancer survivors
This study tests whether a special breathing exercise (functional inspiratory muscle training) can help people recover better after lung cancer surgery. If you are between 18 and 80, have completed your lung cancer treatment, and are now in remission, this program may improve your breathing and strength.
Ankara, ÇankayaAges 18–80 - NCT06245603Recruiting
Testing Hydeal Cyst with standard treatment for bladder cancer
This study tests a bladder instillation called Hydeal Cyst, given alongside standard BCG or MMC therapy, to see if it helps reduce side effects or improve outcomes for people with non-muscle invasive bladder cancer.
BergamoAges 18 years+ - NCT06185179RecruitingEarly Phase 1
Metformin for muscle recovery in older adults
This study tests whether a common diabetes medicine called metformin can help your muscles recover faster after a minor injury. You may qualify if you are 60 or older, generally healthy, and not taking certain medicines.
Salt Lake City, UtahAges 60 years+
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Common questions
- Are there clinical trials for muscle?
- Yes. Clin2 currently lists 1,109 recruiting muscle studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a muscle trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a muscle trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.