Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 467 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07317310Recruiting
Joint health and weight loss study for knee osteoarthritis patients
This trial tests a joint health program for people with knee osteoarthritis and a BMI of 27 or higher. The goal is to see if it can improve knee pain and help with weight management.
Taipei, TaiwanAges 18–75 - NCT03524222Recruiting
Home hospital care for adults after sudden illness
This trial tests whether certain adults can safely receive hospital-level care at home instead of staying in the hospital, using a home care team. It may help you recover in your own home if your condition fits their plan and you have support at home.
Boston, MassachusettsAges 18 years+ - NCT04500665RecruitingPhase 2
Colchicine for kidney-related heart inflammation
This Phase 2 trial tests whether colchicine can reduce inflammation and improve heart function in people with kidney disease and a certain type of heart problem. If you qualify, you’ll be closely monitored for side effects and lab changes.
Boston, MassachusettsAges 21–80 - NCT05290363Recruiting
Studying a blood signal in active spondyloarthritis
This study looks at how a body signal called IL-23 may drive inflammation in spondyloarthritis (including joints) using samples from your care. It may help researchers identify which body cells and targets are involved, and how treatments could work better for active disease.
CréteilAges 18 years+ - NCT05817786Recruiting
Electrical nerve stimulation for persistent arm nerve pain
This trial tests whether stimulating the nerve roots in the shoulder area can reduce long-lasting nerve pain in one arm. It may help people whose arm pain has not improved with standard nerve-pain treatments.
Lyon, FranceAges 1.5 years–80 years - NCT06087510RecruitingPhase 4
Different doses of esketamine and dexmedetomidine for pain after scoliosis surgery
This trial tests two different doses of esketamine and dexmedetomidine to see which provides better pain relief after scoliosis correction surgery. It aims to improve your recovery and long-term outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07694544RecruitingPhase 1
Oral EC5026 study in people with kidney disease
This trial tests a medication called EC5026 in people with and without chronic kidney disease (CKD) to see how the body handles it. It helps understand if dose adjustments are needed for people with impaired kidney function.
Sacramento, CaliforniaAges 55 years+ - NCT06453109Recruiting
Focused ultrasound for chronic back pain with opioid use
This study tests whether focused ultrasound (a non-invasive treatment using sound waves) can help people with chronic back pain who also have opioid use disorder and anxiety. It aims to find a better way to manage pain without relying on opioids.
Washington D.C., District of ColumbiaAges 18–75 - NCT06644261RecruitingPhase 4
Comparing two methods of nerve block for pelvic pain
This study compares two ways to give a pudendal nerve block—one through the vagina, one through the buttock with X-ray guidance—to see which works better for women with pudendal neuralgia (nerve pain in the pelvic area). It may help find a more effective and comfortable treatment option.
Louisville, KentuckyAges 18 years+ - NCT06796985RecruitingPhase 1
Botox for Chronic Pelvic Pain in Women
This study tests whether a Botox injection into the pelvic floor muscles can reduce chronic pelvic pain. It is for women who have had pelvic pain for at least 6 months, with tender muscle knots in the pelvic area.
Miami, FloridaAges 18–75 - NCT06885931Recruiting
Nerve stimulation trial for mixed urinary incontinence
This trial tests a new implant that stimulates a nerve in your pelvic area to help control both stress and urge urine leaks. It might be an option if you've tried other treatments like bladder training or medicine and they didn't help enough or caused side effects.
Leuven, Herestraat 49Ages 22 years+ - NCT06962475Recruiting
Custom foot orthotics for chronic forefoot pain
This trial tests if custom foot orthotics (shoe inserts) can reduce chronic pain under the ball of the foot. If you have had forefoot pain for at least 3 months and can walk without a cane or walker, you may be able to join.
Trois-Rivières, QuebecAges 18 years+ - NCT06977100Recruiting
Journaling study for jaw pain with other chronic pain conditions
This study tests if a journaling program can help people with jaw pain and at least one other chronic pain condition (like fibromyalgia, IBS, or migraines). You will write about your thoughts and feelings to see if it reduces pain and improves well-being.
Gainesville, FloridaAges 18–80 - NCT07035314Recruiting
Comparing medicines for pain after tonsil removal in children
This study compares two ways to manage pain after tonsil removal in children: a medication given by mouth or injection versus a medication applied directly to the surgical site. The goal is to find which approach works better for pain control.
CairoAges 4–10 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07347041Recruiting
Trigger point injections for hip osteoarthritis pain
This study tests if injecting pain-relieving medication into tight muscle knots (called trigger points) can reduce hip pain from osteoarthritis. It is for people who still have pain despite trying other treatments.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07494864Recruiting
Urinary tract health and microbiome study
This study looks at how bacteria and the immune system affect the lower urinary tract. It includes healthy volunteers and people with various urinary conditions, like infections or bladder pain.
Zurich, Canton of ZurichAges 18 years+ - NCT07588230Recruiting
Nerve Block for Minimally Invasive Heart Valve Surgery Pain
This study tests a targeted nerve block (pain-numbing injection) to help manage pain after minimally invasive heart valve surgery. Researchers want to see if this technique reduces pain and the need for opioid medications during recovery.
Diyarbakır, Outside of the USAges 18–75 - NCT07600229Recruiting
Barefoot Walking vs. Standard Care for Heel Pain
This study compares barefoot walking to standard conservative care (like stretching and supportive shoes) for plantar fasciitis—a common cause of heel pain. Researchers want to see if walking barefoot helps reduce pain and improve function in people with persistent heel discomfort.
Carlow, Carlow CountyAges 18–70 - NCT07603960Recruiting
Cold therapy to ease endometriosis pelvic pain
This study tests whether exposing your whole body to very cold air (below freezing) can reduce chronic pelvic pain from endometriosis and improve your quality of life. Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus, often causing pain.
Edinburgh, ScotlandAges 16 years+ - NCT06936800Enrolling by invitation
Pinaverium Bromide to Prevent Pain After Shock Wave Treatment
This trial tests if a drug called pinaverium bromide can help prevent pancreatitis and reduce pain after a procedure that uses shock waves to break up large gallstones in the pancreas. It may be an option for people with chronic pancreatitis and stones that are at least 5 mm wide.
Jinan, Wenhuaxi RoadAges 18–85 - NCT07317518Recruiting
Taping for chronic low back pain
This trial tests two different kinesio taping methods for people with chronic low back pain. The goal is to see how taping affects the fascia (connective tissue) in the lower back and whether it can help relieve pain.
Center, Kirşehi̇rAges 18–65 - NCT04824248Recruiting
Weight-loss program for chronic low back pain
This trial studies whether weight loss can improve long-lasting, non-specific low back pain. It may help people whose back pain is partly related to extra weight by testing a structured approach over time.
BrusselsAges 18–65 - NCT07338045Recruiting
Baduanjin exercise for chronic low back pain in office workers
This trial tests whether an eight-week Baduanjin exercise program can reduce chronic low back pain and improve daily function in office workers. Baduanjin is a gentle mind-body practice that involves slow movements and breathing, and it may help relieve pain caused by prolonged sitting.
Xi'an, ShaanxiAges 20–55
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 467 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.