Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 467 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT07684820RecruitingPhase 2
A study of ExPD-101 for COPD with chronic bronchitis and frequent flare-ups
This study tests an experimental drug (ExPD-101) given daily as a pill for 52 weeks for people with COPD who have chronic bronchitis and frequent flare-ups. It compares the drug to a placebo (inactive pill) to see if it reduces flare-ups and improves symptoms.
Phoenix, ArizonaAges 40–85 - NCT06068322Recruiting
Very intense interval training for people with COPD
This study tests whether a very intense, short burst of exercise (supramaximal high-intensity interval training) is safe and effective for people aged 60 and older with or without COPD. It aims to see if this type of exercise can improve fitness and daily life.
Hasselt, DiepenbeekAges 60 years+ - NCT06205875Recruiting
High vs. low dose pain block after minimally invasive heart valve surgery
This trial compares two doses of a numbing medicine injected into the chest wall to control pain after heart valve surgery. If you qualify, you will receive either a higher or lower dose of the pain block to see which provides better pain relief and recovery.
Hasselt, LimburgAges 18 years+ - NCT06716411Recruiting
Acupuncture for Gulf War Illness relief
This study tests whether acupuncture can help relieve Gulf War Illness symptoms like fatigue, mood or thinking problems, and muscle or joint pain. You may be able to join if you were deployed to the Gulf region and have had these symptoms for more than 6 months.
Berkeley, CaliforniaAges 18 years+ - NCT06749262Recruiting
Inclined vs. standard exercise for COPD
This study compares walking on an incline to standard walking for people with COPD. It aims to find which exercise method is better for improving breathing and mobility.
Omaha, NebraskaAges 45–80 - NCT06915012Recruiting
Test of light therapy for long-term severe arthritis pain
This study tests a non-drug therapy called biophoton therapy to see if it can reduce chronic severe arthritis pain. It may be an option if you've had pain for at least 3 months and are not using certain medical implants.
Butler, PennsylvaniaAges 18–80 - NCT07557108Recruiting
Nerve Blocks to Improve Recovery After Heart Surgery
This study tests whether special numbing injections around nerves in the chest wall (fascial plane blocks) help patients recover better and have less pain after open-heart surgery. The goal is to see if this technique improves how you feel and function in the days after your operation.
Ordu, AltinorduAges 18–70 - NCT06827379Enrolling by invitation
Breathing exercise for muscle and nerve health in COPD
This trial tests whether a special breathing exercise (inspiratory muscle training) can improve how your muscles work and your body's automatic responses, like heart rate. It's a one-time session for people with stable COPD.
João Pessoa, ParaíbaAges 40–75 - NCT06578234RecruitingPhase 4
Comparing Adenosine Doses for Heart MRI
This study will compare different doses of adenosine during a heart MRI to find the best dose for measuring blood flow to the heart muscle. It is for people with known or possible coronary artery disease or heart failure, as well as healthy volunteers.
LundAges 40 years+ - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT07128420Enrolling by invitationPhase 1
Microneedling for chronic Peyronie's disease: a pilot study
This pilot study tests whether microneedling (tiny needles used on the skin) can safely and effectively reduce the curve caused by Peyronie's disease. If you have had a stable curve for at least 6 months and have not tried other treatments recently, you may be able to join.
Ottawa, OntarioAges 18 years+ - NCT05617365RecruitingPhase 1/Phase 2
Study treatment for chronic neck-related head and neck pain
This early-stage study tests a new treatment for people (women) who have long-lasting headaches and pain coming from the neck. It may help reduce symptoms, but you must match specific safety and diagnosis requirements.
East Lansing, MichiganAges 18–65 - NCT05066334RecruitingPhase 2
Back pain trial using your own stem cells in discs
This Phase 2 trial tests whether injecting your own stem cells into a few back discs can reduce chronic low back pain that has not improved with standard treatments. It may help by targeting disc-related (degenerative) wear seen on MRI, but it requires detailed MRI and blood test screening.
Roma, ItalyAges 18–65 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT04730700Recruiting
Radiofrequency treatment test for facet back pain
This study compares a nerve procedure (radiofrequency “neurotomy” using an expandable electrode) to non-procedure medical care for long-lasting low back pain from facet joints. It aims to see whether the procedure helps more safely than conservative treatment.
Kansas City, KansasAges 18 years+ - NCT07629323Enrolling by invitation
Spinal Pain Relief During Hiatal Hernia Surgery
This trial tests whether injecting pain medication directly into the spinal fluid during a minimally invasive stomach surgery (called fundoplication) helps reduce pain after the operation. Fundoplication is used to treat severe acid reflux.
Karlstad, Värmland CountyAges 18 years+ - NCT05880212Recruiting
STOPS low back and leg pain approach for Bangladesh
This trial tests a specific physiotherapy program (“STOPS approach”) for people with long-lasting low back pain or leg pain from the back. It aims to see if the structured treatment, delivered by trained physiotherapists, improves pain and function over about 10 weeks.
Dhaka, UttaraAges 18–65 - NCT06751160Recruiting
Dry needling vs. soft tissue massage for tight hamstrings
This study compares two treatments—dry needling and soft tissue massage—to see which works better for relieving tight hamstring muscles in people with low back pain.
Lahore, Punjab ProvinceAges 20–40 - NCT06080464Recruiting
Doctor satisfaction with VERABAND™ for chronic low back pain
This study tests how satisfied doctors are with a wearable device called VERABAND™ that monitors movement in people with chronic low back pain. If your pain limits your ability to move, you may be able to help researchers understand if this device is useful during your regular non-surgical treatment.
La Jolla, CaliforniaAges 18–85 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04734106RecruitingEarly Phase 1
Aloe vera for bladder pain and frequent urination
This early-stage study tests whether aloe vera can reduce symptoms of interstitial cystitis, such as bladder pain and frequent urination. You’d help researchers check both safety and symptom relief.
Winston-Salem, North CarolinaAges 18–80
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 467 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.