Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 213 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05144503Recruiting
Test of a new catheter procedure for irregular heart rhythm
This study checks how safe and effective a special catheter procedure (SpherePVI) is for treating paroxysmal (comes and goes) or persistent atrial fibrillation. You may be considered if your atrial fibrillation keeps returning and you’ve already tried at least one medication but it didn’t work or you couldn’t tolerate it.
VilniusAges 18–75 - NCT05266144Recruiting
Catheter ablation for non-valvular atrial fibrillation
This trial studies catheter ablation, a procedure that targets heart rhythm triggers, for people with atrial fibrillation (an irregular heartbeat). It may help improve rhythm control, but you must meet specific heart and testing requirements and avoid certain conditions.
Beijing, Beijing MunicipalityAges 18–80 - NCT05332457Recruiting
Beta-blocker effects on heart rate and exercise capacity in atrial fibrillation
This study looks at how taking a beta-blocker affects your resting heart rate during activity and how fit your heart and lungs are during an exercise test. It may help clarify whether the way the medication controls heart rate is linked to better exercise tolerance in people with persistent atrial fibrillation.
TaipeiAges 20 years+ - NCT05366361Recruiting
Study of persistent atrial fibrillation during heart procedures
This study looks at what happens in the heart in people with persistent atrial fibrillation when they undergo an ablation or Maze surgery. It may help doctors better understand the condition and improve future care for people needing these procedures.
Stanford, CaliforniaAges 22–80 - NCT05371405Recruiting
Using computer learning to improve care for atrial fibrillation patients
This study uses machine learning (computer pattern-finding) to better understand atrial fibrillation and guide care around the time of an ablation procedure. It may help refine how doctors treat certain AF patients based on their heart patterns.
Stanford, CaliforniaAges 22–80 - NCT05411614Recruiting
Testing two heart procedures for atrial fibrillation in heart failure
This study compares two different ablation procedures (treatments that target heart rhythm triggers) for people with atrial fibrillation and reduced heart pumping. It aims to see which approach works best and is safest for improving your heart rhythm when you also have heart failure.
ChertseyAges 18 years+ - NCT05776797Recruiting
Ablation vs best medicines for CRT patients with permanent atrial fibrillation
This trial compares two approaches—an AV junction ablation procedure versus continued best medical treatment—in people who already have a heart device for heart failure (CRT) but still have ongoing permanent atrial fibrillation. It aims to improve how well your heart rhythm is controlled and how effectively the device can pace your heart.
Liberec, Liberec RegionAges 18–85 - NCT05790707Recruiting
Ablation for persistent atrial fibrillation to help memory
This study checks whether a procedure called atrial fibrillation ablation can slow memory problems in people who already have mild cognitive impairment. Participants will be tested on thinking and memory before and after treatment to see if the procedure helps.
AngersAges 60–80 - NCT05794386Recruiting
Ablation plan guided by left-heart scar map for persistent atrial fibrillation
This study tests whether using a 3D heart “scar map” helps doctors choose a better catheter ablation strategy for people with persistent atrial fibrillation (AF). It may help reduce ongoing AF by targeting the scar area in the left atrium.
Seoul, Jongno-guAges 19 years+ - NCT05826665Recruiting
Study of heart rhythm mapping during AF ablation
This is an observational study that looks at how a special heart mapping system may affect the procedure and outcomes for people having ablation for persistent atrial fibrillation (AF). It may help doctors better understand what works best and how procedures turn out.
Jonesboro, ArkansasAges 18–80 - NCT05872776Recruiting
Home ECG monitoring to reduce atrial fibrillation episodes
This trial uses a home heart monitor (a chest patch with an ECG) to study how atrial fibrillation (an irregular heartbeat) changes over time and how this may help manage symptoms. You may be included if you have a documented, short-lasting type of atrial fibrillation and a moderate amount of AF seen on a 14-day heart recording.
Tel AvivAges 18–85 - NCT05890664RecruitingPhase 3
Colchicine after shock treatment to stop atrial fibrillation
This trial tests whether colchicine given after cardioversion (a procedure that restores normal rhythm) helps keep the heart in normal rhythm afterward. It may help some people have fewer early returns of atrial fibrillation.
Bruderholz, Basel-LandschaftAges 18 years+ - NCT05903170Recruiting
Shock energy study for heart rhythm conversion in atrial fibrillation
This trial tests whether using a specific “shock energy” during electrical cardioversion works safely and effectively for people with persistent atrial fibrillation. You might be eligible if your cardioversion is planned (not an emergency) and your doctors determine you can safely take blood thinners.
Wellington, Wellington RegionAges 18 years+ - NCT05961865Recruiting
Study of inflammation during catheter ablation for atrial fibrillation
This study measures changes in inflammation in people with atrial fibrillation (AF) who are getting a catheter ablation procedure. It may help doctors better understand what happens in the body during the procedure and why some patients do better than others.
MilanAges 18–85 - NCT05978388Recruiting
CT scan before catheter ablation for atrial fibrillation
This trial is testing whether a coronary CT angiography scan, performed before catheter ablation for atrial fibrillation, helps doctors find hidden blockages in heart arteries. It may help people without known heart disease avoid unnecessary procedures.
Hellerup, Capital RegionAges 18 years+ - NCT06023888Recruiting
Heart rhythm analysis for persistent atrial fibrillation
This study tests a new way to analyze heart signals in people with long-standing atrial fibrillation that hasn't gotten better with medication. It may help doctors understand your heart rhythm better and guide future treatments.
TaipeiAges 20–80 - NCT06108414RecruitingPhase 4
Low-dose vs standard-dose blood thinner for older adults with atrial fibrillation
This trial tests whether a lower dose of the blood thinner rivaroxaban works as well as the standard dose for people 70 and older with atrial fibrillation (an irregular heartbeat). The goal is to find the safest dose to prevent strokes while reducing bleeding risks.
Beijing, Beijing MunicipalityAges 70 years+ - NCT06165510Recruiting
Convergent ablation and left atrial appendage isolation for persistent AF
This trial tests a two-step procedure for persistent atrial fibrillation that combines a heart ablation with isolation of a small heart pouch. It aims to see if this approach is more effective than standard care.
LondonAges 18–80 - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT06249269Recruiting
Lifestyle Change to Improve AF Ablation Results
This trial tests whether a healthy lifestyle program (including exercise and weight loss) can help people with atrial fibrillation (AF) who are overweight or have related health risks. You will have a catheter ablation procedure, and the study will see if lifestyle changes improve your heart's rhythm long-term.
Calgary, AlbertaAges 18 years+ - NCT06249347Recruiting
New ablation approach for persistent atrial fibrillation with stroke risk
This trial tests a new type of catheter ablation (using heat to create scar lines in the heart) for people with persistent atrial fibrillation who have a higher risk of stroke or bleeding. It aims to see if this approach can help prevent strokes and reduce the need for long-term blood thinners.
Wenzhou, ZhejiangAges 18 years+ - NCT06263608Recruiting
Sleep apnea testing and treatment for atrial fibrillation patients
This study tests a new way to check and treat sleep apnea in people with atrial fibrillation (AF). If you have AF and symptoms, you may be able to join and get sleep tracking and treatment that could help both your heart and sleep.
EdegemAges 18 years+ - NCT06322017Recruiting
Early vein isolation for atrial fibrillation in older adults
This study compares doing vein isolation soon after diagnosis versus usual care in people 75+ with new or early atrial fibrillation. The goal is to see if early treatment prevents the condition from getting worse and improves quality of life.
Nantes, Loire AtlantiqueAges 75 years+ - NCT06363604Recruiting
Alcohol injection with ablation for persistent atrial fibrillation
This trial is testing a new approach to treat persistent atrial fibrillation (a type of irregular heartbeat) by combining standard catheter ablation with a special injection of alcohol (ethanol) into certain heart veins. It may help people whose symptoms haven't improved with medication.
Shanghai, Shanghai MunicipalityAges 18–85
Hear when a new Persistent Atrial Fibrillation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 213 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.