Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 213 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06698159Recruiting
Wider pulmonary vein isolation in AFib ablation with single-shot cryoablation
This study tests a new approach to a common procedure for atrial fibrillation (AFib) called pulmonary vein isolation. It uses a single-shot cryoablation technique to treat people with paroxysmal or persistent AFib.
Pozzilli, IserniaAges 18 years+ - NCT07626411RecruitingPhase 3
Blood Thinner Study for Irregular Heartbeat
This study tests a new blood thinner to prevent strokes and blood clots in people with atrial fibrillation (a common heart rhythm problem). You may qualify if you have atrial fibrillation and at least one risk factor for stroke, or if you've never taken a blood thinner before.
Alexander City, AlabamaAges 18 years+ - NCT07621003Recruiting
PULSed Field Ablation for New-Onset Atrial Fibrillation
This study tests a newer ablation technique using pulsed electrical energy to treat atrial fibrillation (an irregular heartbeat). You may qualify if you were recently diagnosed with AF and haven't had ablation before.
Bad OeynhausenAges 18 years+ - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT07575269Recruiting
New ablation treatment for irregular heartbeat
This trial tests a new tool called FARAFLEX that uses pulsed electrical energy to treat atrial fibrillation (an irregular heart rhythm). The goal is to see if this method can safely stop AF symptoms in people whose medications haven't worked.
Jonesboro, ArkansasAges 18 years+ - NCT07563257Recruiting
Comparing Two Mapping Catheters for Heart Rhythm Ablation
This trial compares two types of specialized catheters used during heart rhythm ablation procedures to help doctors confirm they've created the right burn patterns. If you're having ablation for persistent atrial fibrillation or flutter with complex burn lines planned, this trial may help improve how your procedure is done.
Be’er Ya‘aqovAges 18 years+ - NCT06654401Recruiting
Using electrical shock to restore normal heart rhythm after surgery
This study looks at whether giving an electrical shock (cardioversion) right after heart surgery can help people with long-lasting atrial fibrillation keep a normal heartbeat. It may help guide future treatment decisions for patients who have not gotten better with medication.
Saint Petersburg, Sankt-PeterburgAges 18 years+ - NCT07535268Recruiting
Heart rhythm ablation outcomes in minority patients
This registry tracks outcomes for racial and ethnic minority patients undergoing a specific type of heart rhythm treatment (ablation) for atrial fibrillation. The goal is to understand how well this treatment works across different populations.
New York, New YorkAges 18 years+ - NCT07527299Recruiting
Varipulse catheter study for persistent atrial fibrillation
This study tests a new catheter to treat persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year). It aims to isolate the pulmonary veins and superior vena cava to restore normal rhythm. Some participants may also receive a left atrial appendage occlusion device if needed.
Birmingham, AlabamaAges 18–80 - NCT07523750Recruiting
Pulsed field ablation for persistent atrial fibrillation
This study tests two types of pulsed field ablation catheters to treat persistent atrial fibrillation, a heart rhythm problem lasting more than 7 days but less than a year. The goal is to see if these catheters can safely and effectively restore a normal heart rhythm.
Jonesboro, ArkansasAges 18–80 - NCT07523620Recruiting
Heart rhythm procedure with left atrial appendage closure
This trial tests a procedure that closes off a small pouch in the heart (left atrial appendage) while also treating irregular heartbeat (atrial fibrillation) with a catheter ablation procedure. The goal is to reduce your stroke risk and treat your symptoms without needing blood thinners long-term.
Brussels, B CAP RAges 18 years+ - NCT07508618RecruitingPhase 4
Qidong Yixin Granule for preventing atrial fibrillation after ablation
This trial tests whether a traditional Chinese medicine granule, Qidong Yixin, can help prevent atrial fibrillation from coming back after a heart ablation procedure. It is for people with persistent atrial fibrillation who have not had good results from other heart rhythm medications.
HangzhouAges 18–80 - NCT06775028Recruiting
Integrated care for older adults with atrial fibrillation
This trial is testing a new approach to care for older adults with atrial fibrillation (an irregular heartbeat) who also have other health conditions. It aims to see if a more integrated, team-based care plan helps improve their overall health and quality of life.
HaskovoAges 65 years+ - NCT07446244Enrolling by invitation
Catheter ablation for advanced atrial fibrillation
This trial tests a special type of catheter ablation (using electric pulses called electroporation) to treat people with long-lasting atrial fibrillation and a very enlarged left atrium. It may offer a new treatment option when standard approaches are limited.
Ljubljana, OsrednjaslovenskaAges Up to 80 years - NCT07444320Recruiting
Testing new energy pulses for atrial fibrillation treatment
This trial tests a new way to deliver energy (FARAPULSE PFA system) to treat atrial fibrillation (AF), a type of irregular heartbeat. It aims to see if these new waveforms can safely and effectively stop AF symptoms and improve quality of life.
SplitAges 18 years+ - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07424690Recruiting
Comparing ablation with medication care for older adults with atrial fibrillation
This study compares two approaches for older adults with atrial fibrillation: a procedure called catheter ablation (which uses heat or cold to fix the heart's rhythm) versus conservative care (medications and lifestyle changes). The goal is to see which approach is better for improving quality of life and reducing symptoms in people aged 78 and above.
LinköpingAges 78 years+ - NCT07424326Recruiting
Extended ablation vs. standard treatment for persistent atrial fibrillation
This trial compares two catheter ablation techniques for people with persistent atrial fibrillation (a type of irregular heartbeat that doesn't go away on its own). It will test whether a more extensive ablation (burning more heart tissue) works better than the standard procedure of isolating the pulmonary veins (the veins that bring blood from the lungs to the heart). If you have this condition and have had at least one episode in the past year, this study might help you find a more effective treatment.
OlomoucAges 18–80 - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT06825104Recruiting
Long-term comparison of two ablation methods for persistent AF
This long-term study follows people who already completed a 12-month study comparing two types of heart ablation for persistent atrial fibrillation. It looks at how well the treatments worked over time.
BronAges 18 years+ - NCT07298473Recruiting
Redo ablation for recurrent atrial fibrillation with Sphere-9 catheter
This trial tests a new catheter and system for people who have had one previous ablation for atrial fibrillation but still have symptoms. It aims to see if a repeat procedure can safely and effectively treat recurrent episodes.
Birmingham, AlabamaAges 18 years+ - NCT07301190Recruiting
Study of PFLotus for persistent atrial fibrillation
This study tests a new device called PFLotus for people with persistent atrial fibrillation (AF), a type of irregular heartbeat. The goal is to see if it can help restore a normal heart rhythm in people who haven't gotten better with medicine.
ChengduAges 18–75 - NCT05332457Recruiting
Beta-blocker effects on heart rate and exercise capacity in atrial fibrillation
This study looks at how taking a beta-blocker affects your resting heart rate during activity and how fit your heart and lungs are during an exercise test. It may help clarify whether the way the medication controls heart rate is linked to better exercise tolerance in people with persistent atrial fibrillation.
TaipeiAges 20 years+ - NCT07273994RecruitingPhase 4
Comparing two amiodarone doses after heart shock treatment for atrial fibrillation
This trial tests two different ways of taking amiodarone (a heart rhythm medicine) to keep your heart in a normal rhythm after a procedure called electrical cardioversion. It's designed for people with persistent atrial fibrillation (a fast, irregular heartbeat lasting at least 7 days).
BarcelonaAges 18 years+
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Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 213 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.