Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06358391Recruiting
Comparing two needles for left atrial access in heart procedures
This trial compares two devices used to create a small opening in the wall between the upper chambers of the heart so doctors can reach the left side to treat heart rhythm problems or other conditions. It may help if you need a left atrial procedure and are healthy enough for the puncture.
Bucheon-siAges 18 years+ - NCT03243175RecruitingPhase 3
Avoiding blood thinners after brain bleeding in atrial fibrillation
This Phase 3 trial studies whether it’s safer to avoid long-term blood thinners after a spontaneous brain bleed in people with atrial fibrillation (an irregular heart rhythm). It compares different prevention strategies to lower the risk of stroke or other blood-vessel problems without causing new, serious bleeding.
LilleAges 18 years+ - NCT07620262Recruiting
Combined atrial fibrillation treatment and stroke prevention study
This study tests a new approach for people with atrial fibrillation (a type of irregular heartbeat) who are also at high risk for stroke. It combines a procedure to fix the heart's electrical signals with closing off a small pouch in the heart to reduce stroke risk, potentially avoiding long-term blood thinners.
Bay Shore, New YorkAges 18 years+ - NCT07390175Recruiting
New heart-ablation method for long-lasting arrhythmias
This study tests a new way to destroy the tissue causing dangerous heart rhythms using a detailed model of how the heart's electrical signals spread. It may be an option for people with long-lasting atrial fibrillation or hard-to-control ventricular arrhythmias who are already scheduled for a standard ablation procedure.
Madrid, MadridAges 18 years+ - NCT06402851RecruitingPhase 4
Blood thinner or none for atrial fibrillation with dialysis
This trial compares two types of blood thinners (vitamin K antagonists and factor Xa inhibitors) versus no blood thinner in people with atrial fibrillation who are on dialysis or have very advanced kidney disease. It aims to see which option is safest and most effective for preventing strokes and bleeds.
Salvador, Estado de BahiaAges 18 years+ - NCT06578104Recruiting
Pulsed AF Study: PulseSelect Catheter for Afib
This study tests a new way to treat atrial fibrillation (Afib) using a special catheter system called PulseSelect that delivers short bursts of energy to create scar tissue in the heart. It is for people whose Afib comes and goes or stays for a while but not more than a year, and who have not had a prior ablation procedure or have a pacemaker or defibrillator.
Tampa, FloridaAges 18 years+ - NCT06199180Recruiting
Comparing two ablation methods for repeat atrial fibrillation treatment
This trial tests a newer type of energy (pulsed field ablation) against the standard heat-based method (radiofrequency) for people who have already had one ablation and now have atrial fibrillation again. The goal is to see which works better for keeping your heart in a normal rhythm.
GroningenAges 18–80 - NCT07390214Recruiting
Comparing two catheters for repeat atrial fibrillation ablation
This study compares two types of catheters (AFFERA vs. standard contact-force guided) for a repeat ablation procedure in people whose atrial fibrillation or related symptoms returned after a first ablation. It aims to find which catheter works best for a second treatment.
Frankfurt am Main, HesseAges 18–85 - NCT05841056RecruitingPhase 3
Short amiodarone treatment to prevent new heart rhythm after surgery
This trial studies whether a short course of amiodarone started right after heart surgery can reduce problems from new-onset atrial fibrillation (a common fast heart rhythm) or flutter. It may help some patients avoid ongoing rhythm issues and improve recovery soon after discharge.
Hamilton, OntarioAges 18 years+ - NCT07308847Recruiting
Study of a new catheter system for treating atrial fibrillation
This trial tests a new catheter and mapping system designed to treat paroxysmal atrial fibrillation (AF), which is a type of irregular heartbeat that comes and goes. If you have this condition, the study aims to see how well the new system works with a minimally invasive procedure.
Jonesboro, ArkansasAges 18–80 - NCT03830320RecruitingPhase 1
PET scan to look for blood clots in the heart or lungs
This Phase 1 study uses a PET scan to detect blood clots (thrombosis) in specific groups of people. It’s testing how well the scan can find clots and how it should be timed with other heart or illness tests.
Boston, MassachusettsAges 18–85 - NCT03907046RecruitingPhase 3
Blood thinner study to prevent stroke after brain bleed
This Phase 3 study tests whether a blood thinner (apixaban) can help prevent another stroke and support recovery after you’ve had a brain bleed. You would be assigned to a treatment group, and the study checks safety and whether strokes can be reduced without causing dangerous bleeding.
Birmingham, AlabamaAges 18 years+ - NCT04005508Recruiting
Study sleep apnea and heart outcomes in high-risk atrial fibrillation
This trial looks at how obstructive sleep apnea (OSA, a breathing problem during sleep) relates to heart outcomes in people with atrial fibrillation (AF). It may help doctors better predict risk and choose safer care for people who are high cardiovascular risk.
SingaporeAges 22–99 - NCT04628078Recruiting
Echocardiogram-guided heart procedure registry for atrial fibrillation
This study keeps a real-world record of people with atrial fibrillation who are planning a procedure to close off the heart’s left atrial appendage. Doctors use echocardiography (heart ultrasound) to guide the closure and track outcomes to improve care.
BernAges 18 years+ - NCT04695106RecruitingPhase 4
Blood Thinner and Heart Attack Prevention Study
This study tests whether taking dabigatran (a blood thinner) combined with ticagrelor (a blood clot preventer) is safe and effective for patients with irregular heart rhythm (atrial fibrillation) who recently had a heart attack and received a stent. The goal is to prevent future blood clots while minimizing bleeding risks.
Gdansk, Pomeranian VoivodeshipAges 18 years+ - NCT07429214Recruiting
Study of a new catheter for atrial fibrillation ablation
This trial tests a new catheter system to treat atrial fibrillation (AF) by creating small scars in the heart to block faulty signals. It may help people with symptoms that continue despite medication and who are scheduled for a standard ablation procedure.
AalstAges 18–75 - NCT05432024Recruiting
Heart MRI checks how well ablation lesions form
This study uses a special heart MRI to look at how ablation creates scar tissue in people with atrial fibrillation. It may help doctors improve how ablation is done and understand which technique works best.
NieuwegeinAges 18 years+ - NCT05717725RecruitingPhase 3
Pulsed heart ablation vs fake procedure for irregular heartbeat
This trial tests whether pulsed-field ablation (a targeted treatment meant to stop abnormal heart signals) works better than a sham, or “placebo,” ablation. It is for certain people with atrial fibrillation (AF) to see if symptoms and heart rhythm outcomes improve.
PragueAges 18 years+ - NCT05773768Recruiting
Care pathway study for newly diagnosed atrial fibrillation patients
This study looks at new care plans (“care pathways”) and how well they work, including cost and health outcomes. It may help by comparing whether a different follow-up approach after a new atrial fibrillation diagnosis leads to better care, especially for older adults.
GroningenAges 65 years+ - NCT06065124Recruiting
Study on weight loss surgery for heart failure with irregular heartbeat
This trial tests if weight loss surgery can help people with heart failure and atrial fibrillation (an irregular heartbeat) improve their heart condition. You may join if you are between 45 and 70, have a BMI of 32 to 40, and have mild to moderate heart failure with preserved pumping function.
Arnhem, GelderlandAges 45–70 - NCT06220006Recruiting
Comparing heart tissue burns for atrial fibrillation treatment
This study compares two ways to create small burns in the heart tissue to fix an irregular heartbeat (atrial fibrillation). It uses a special MRI to see how well each method works.
Barcelona, CataloniaAges 18 years+ - NCT06253000Recruiting
Heat vs. Freezing for the Back of the Heart
This trial tests two ways to treat the back wall of the heart's left chamber in people with stubborn atrial fibrillation. It compares radiofrequency (heat) and cryoablation (freezing) to see which is safer and works better.
MoscowAges 18–80 - NCT06542263Recruiting
CPAP for preventing AF recurrence after ablation in people with AF and sleep apnea
This study tests whether using a CPAP machine at night can help prevent atrial fibrillation from coming back after a heart procedure called catheter ablation. It is for people who have both AF and moderate to severe obstructive sleep apnea.
Suzhou, JinagsuAges 18 years+ - NCT06556667Recruiting
Comparing two cardioversion methods for persistent AFib
This trial compares two ways of doing cardioversion (a procedure to restore normal heart rhythm) for people with persistent atrial fibrillation. It aims to see if one approach leads to a better recovery and fewer complications.
Ottawa, OntarioAges 18 years+
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Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 212 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.