Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 213 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05963698Recruiting
Closing off a heart pouch to prevent stroke
This study tests a procedure that seals off the left atrial appendage (a small heart pouch) to help prevent stroke in people with atrial fibrillation. You may be considered if your stroke risk is high and you are already on blood-thinner medicine.
Birmingham, AlabamaAges 18 years+ - NCT03243175RecruitingPhase 3
Avoiding blood thinners after brain bleeding in atrial fibrillation
This Phase 3 trial studies whether it’s safer to avoid long-term blood thinners after a spontaneous brain bleed in people with atrial fibrillation (an irregular heart rhythm). It compares different prevention strategies to lower the risk of stroke or other blood-vessel problems without causing new, serious bleeding.
LilleAges 18 years+ - NCT07454135Recruiting
Studying heart muscle disease and atrial fibrillation
This trial looks at how the heart's electrical signals work in people with hypertrophic cardiomyopathy (a condition where the heart muscle becomes thickened) who also have atrial fibrillation (a type of irregular heartbeat). The goal is to understand these signals better during a planned ablation procedure, which is a treatment to fix the irregular rhythm.
LondonAges 18–80 - NCT07620262Recruiting
Combined atrial fibrillation treatment and stroke prevention study
This study tests a new approach for people with atrial fibrillation (a type of irregular heartbeat) who are also at high risk for stroke. It combines a procedure to fix the heart's electrical signals with closing off a small pouch in the heart to reduce stroke risk, potentially avoiding long-term blood thinners.
Bay Shore, New YorkAges 18 years+ - NCT07390175Recruiting
New heart-ablation method for long-lasting arrhythmias
This study tests a new way to destroy the tissue causing dangerous heart rhythms using a detailed model of how the heart's electrical signals spread. It may be an option for people with long-lasting atrial fibrillation or hard-to-control ventricular arrhythmias who are already scheduled for a standard ablation procedure.
Madrid, MadridAges 18 years+ - NCT06402851RecruitingPhase 4
Blood thinner or none for atrial fibrillation with dialysis
This trial compares two types of blood thinners (vitamin K antagonists and factor Xa inhibitors) versus no blood thinner in people with atrial fibrillation who are on dialysis or have very advanced kidney disease. It aims to see which option is safest and most effective for preventing strokes and bleeds.
Salvador, Estado de BahiaAges 18 years+ - NCT04628078Recruiting
Echocardiogram-guided heart procedure registry for atrial fibrillation
This study keeps a real-world record of people with atrial fibrillation who are planning a procedure to close off the heart’s left atrial appendage. Doctors use echocardiography (heart ultrasound) to guide the closure and track outcomes to improve care.
BernAges 18 years+ - NCT04005508Recruiting
Study sleep apnea and heart outcomes in high-risk atrial fibrillation
This trial looks at how obstructive sleep apnea (OSA, a breathing problem during sleep) relates to heart outcomes in people with atrial fibrillation (AF). It may help doctors better predict risk and choose safer care for people who are high cardiovascular risk.
SingaporeAges 22–99 - NCT07816029Recruiting
Closing a heart pouch to prevent stroke in atrial fibrillation
This study tests a device and procedure to close off a small pouch in the heart (left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke, possibly lowering the need for long-term blood thinners.
PragueAges 18 years+ - NCT07645066Recruiting
Heart Pacemaker Placement to Prevent Irregular Heartbeat
This trial tests a new pacemaker placement technique for people with a slow heartbeat (sinus node dysfunction) who need a pacemaker anyway. The goal is to see if this special placement can help prevent atrial fibrillation, a type of irregular heartbeat that can cause stroke and other complications.
Anqing, AnhuiAges 18 years+ - NCT07618741Recruiting
Improving AF Ablation Outcomes in Patients with Obesity
This study tests whether special care strategies can help obese patients have better results after a catheter ablation procedure for atrial fibrillation (a heart rhythm problem). Catheter ablation uses heat or cold to fix the irregular heartbeats.
TaipeiAges 20 years+ - NCT06199180Recruiting
Comparing two ablation methods for repeat atrial fibrillation treatment
This trial tests a newer type of energy (pulsed field ablation) against the standard heat-based method (radiofrequency) for people who have already had one ablation and now have atrial fibrillation again. The goal is to see which works better for keeping your heart in a normal rhythm.
GroningenAges 18–80 - NCT07574697Recruiting
Genetic Study of Atrial Fibrillation and Heart Function Recovery
This study looks at genetic factors in people with atrial fibrillation (an irregular heartbeat) and weak heart function to understand why some people's hearts recover after treatment and others don't. Researchers will collect blood samples and medical information to identify genetic patterns.
LondonAges 18 years+ - NCT05717725RecruitingPhase 3
Pulsed heart ablation vs fake procedure for irregular heartbeat
This trial tests whether pulsed-field ablation (a targeted treatment meant to stop abnormal heart signals) works better than a sham, or “placebo,” ablation. It is for certain people with atrial fibrillation (AF) to see if symptoms and heart rhythm outcomes improve.
PragueAges 18 years+ - NCT07462910Recruiting
Checking diaphragm nerve function after pulsed field ablation
This study looks at how a new type of catheter ablation (pulsed field ablation) for atrial fibrillation affects the phrenic nerve, which controls the diaphragm. Researchers will use X-rays to see if the treatment causes any temporary diaphragm problems.
MontrealAges 18 years+ - NCT07439016Recruiting
LA function after pulse field ablation for paroxysmal AF
This trial tests how pulse field ablation (a treatment that uses short electrical pulses to correct irregular heartbeats) affects the left atrium's function in people with paroxysmal atrial fibrillation (AFib that comes and goes). It may help if you have paroxysmal AFib and are in normal rhythm at the start of the procedure.
PragueAges 18 years+ - NCT07429214Recruiting
Study of a new catheter for atrial fibrillation ablation
This trial tests a new catheter system to treat atrial fibrillation (AF) by creating small scars in the heart to block faulty signals. It may help people with symptoms that continue despite medication and who are scheduled for a standard ablation procedure.
AalstAges 18–75 - NCT07428564Recruiting
VARIPULSE catheter and TRUPULSE generator for persistent atrial fibrillation
This study tests a new catheter and generator system to treat persistent atrial fibrillation (an irregular heartbeat that lasts more than a week). It may help people whose symptoms haven't been controlled by medication and who need a procedure called ablation to fix the heart's electrical signals.
AalstAges 18–75 - NCT07421076Recruiting
Grid mapping study for atrial fibrillation ablation
This trial tests a new mapping tool to help doctors find and treat the source of atrial fibrillation (AF) during a standard ablation procedure. It may offer a more precise way to guide treatment for people with AF that comes and goes.
Jinan, ShandongAges 18 years+ - NCT07390214Recruiting
Comparing two catheters for repeat atrial fibrillation ablation
This study compares two types of catheters (AFFERA vs. standard contact-force guided) for a repeat ablation procedure in people whose atrial fibrillation or related symptoms returned after a first ablation. It aims to find which catheter works best for a second treatment.
Frankfurt am Main, HesseAges 18–85 - NCT07389434Recruiting
Testing reused catheters for atrial fibrillation treatment
This trial tests whether reusing special catheters to treat atrial fibrillation is safe, effective, and better for costs and the environment. It may help people with atrial fibrillation who need a procedure called pulmonary vein isolation.
ZagrebAges 18 years+ - NCT06844227Recruiting
Virtual Visit to Manage Blood Thinners Around Surgery
This study looks at whether a virtual visit can safely manage your blood thinners around the time of a planned surgery. You would stop your medication before the procedure and restart it after, but all instructions and check-ins happen remotely (phone or video).
Evanston, IllinoisAges 18–100 - NCT07250529Recruiting
Comparing two pacemaker pacing methods for heart block
This study compares two types of pacemaker pacing methods in people with heart block and normal heart pumping function. It looks at how often short bursts of fast heart rhythm occur in the upper heart chambers, which may help improve long-term heart health.
PátraiAges 18 years+ - NCT06065124Recruiting
Study on weight loss surgery for heart failure with irregular heartbeat
This trial tests if weight loss surgery can help people with heart failure and atrial fibrillation (an irregular heartbeat) improve their heart condition. You may join if you are between 45 and 70, have a BMI of 32 to 40, and have mild to moderate heart failure with preserved pumping function.
Arnhem, GelderlandAges 45–70
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Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 213 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.