Clinical trials
Regurgitation clinical trials
Below are recruiting regurgitation clinical trials, each written for real people, not researchers. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06911099Recruiting
Studying mitral valve repair for atrial regurgitation
This trial tests a minimally invasive procedure (transcatheter edge-to-edge repair) to fix a leaky mitral valve caused by an enlarged atrium, not by heart muscle damage. It might be an option if your mitral regurgitation is related to atrial issues and your heart's pumping strength is normal.
The Bronx, New YorkAges 18 years+ - NCT06835946Recruiting
How anesthesia and imaging affect heart valve leak assessment
This study looks at how anesthesia, breathing machines, and imaging methods change the way doctors measure a leaky heart valve. It aims to make sure the severity of aortic regurgitation is accurately measured before surgery.
LiègeAges 18 years+ - NCT06926959Recruiting
Tricuspid regurgitation risk model study
This study aims to develop a risk model for tricuspid regurgitation, a condition where the heart valve doesn't close properly. It may help doctors better understand and treat this condition.
Guangzhou, GuangdongAges 18 years+ - NCT06922526Recruiting
Pacemaker and tricuspid valve health: long-term outcomes
This study looks at how pacemakers and similar heart devices affect the tricuspid valve over time and whether that leads to worse health outcomes. It may help you understand if your device is causing long-term changes.
JinanAges 18 years+ - NCT07172477Recruiting
Early study of the Pivot Extend system for leaky tricuspid valve
This trial tests a new device (Pivot Extend) to fix a severe leak in your tricuspid heart valve. It is for people who still have symptoms like shortness of breath or fatigue despite taking medicine.
Macquarie Park, New South WalesAges 18 years+ - NCT07130994Recruiting
Testing a new less invasive mitral valve replacement (SATURN)
This trial tests a new, less invasive device called the SATURN system to replace a severely leaky mitral heart valve without open-heart surgery. It is for people who are too high-risk for traditional surgery and are willing to take blood thinners.
Los Angeles, CaliforniaAges 18 years+ - NCT07131631Recruiting
MitraClip for leaky heart valve in heart failure patients
This trial tests if the MitraClip device helps people with heart failure and a leaky mitral valve. It uses a special MRI to check how the heart responds to treatment.
Minneapolis, MinnesotaAges 18 years+ - NCT07099859RecruitingPhase 4
Losartan after aortic valve surgery for severe leakage
This trial tests if the drug losartan can help the heart recover better after surgery to replace a leaky aortic valve. It may reduce strain on the heart and improve long-term outcomes.
São Paulo, São PauloAges 18–85 - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT07069673Recruiting
Abbott Cephea mitral valve disease registry
This study tracks people with mitral valve disease who receive the Cephea valve through a tube in an artery rather than open-heart surgery. It looks at how well the valve works over time.
Birmingham, AlabamaAges 18 years+ - NCT07042360Recruiting
Understanding tricuspid valve leakage with non-invasive tests
This trial uses safe, non-invasive tests to study people with moderate or severe tricuspid regurgitation (leaky valve on the right side of the heart). It aims to better understand the condition, which may lead to improved care in the future.
Hong Kong, ShatinAges 18 years+ - NCT06917664RecruitingPhase 4
Treating moderate mitral regurgitation in heart surgery patients
This trial looks at how to treat moderate mitral regurgitation (a leaky heart valve) in people who are already having coronary artery bypass surgery (CABG). It aims to find the best way to manage this condition to improve heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06883864Recruiting
Ablation for leaky valve with constant atrial fibrillation
This study tests whether a catheter ablation procedure (a way to fix abnormal heart rhythms) can help people who have both constant atrial fibrillation and severe mitral regurgitation (a leaky heart valve). It is for people whose heart valve leak is caused by the rhythm problem, not by valve damage.
Hefei, AnhuiAges 18–80 - NCT06876883Recruiting
Mitral regurgitation risk assessment study
This study looks at people with moderate or severe mitral regurgitation (a leaky heart valve) to better understand their risks and create models to guide treatment. It may help your doctor decide on the best care plan for you.
Guangzhou, GuangdongAges 18 years+ - NCT06818084RecruitingPhase 4
TAVR for severe aortic regurgitation using VitaFlow Liberty
This trial tests the VitaFlow Liberty device, a catheter-based treatment for people with severe aortic regurgitation (a leaky heart valve). If you have symptoms or your heart is starting to weaken, this procedure might help avoid open-heart surgery.
Shanghai, Shanghai MunicipalityAges 60 years+ - NCT04500899RecruitingPhase 1/Phase 2
Phenylephrine test to better grade mitral valve leak severity
This trial tests whether a medication called phenylephrine helps doctors measure how severe mitral regurgitation (mitral valve leak) is. If you’re already scheduled for a special ultrasound from the esophagus, this study may help improve how your valve leak is assessed.
New York, New YorkAges 18 years+ - NCT06780241Recruiting
Sex differences in valvular heart disease
This study uses special MRI scans to look at how valvular heart disease (like leaky or narrowed aortic valves) affects men and women differently. It aims to find unique biological patterns that could lead to better treatments.
Cleveland, OhioAges 18–90 - NCT06608823Recruiting
Comparing surgery vs. the Trilogy valve for aortic regurgitation
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
Burlingame, CaliforniaAges Any age - NCT06583876Recruiting
A new device for leaky mitral valves without open-heart surgery
This trial tests a new device for people whose mitral valve leaks badly (grade 3+ or 4+) and who are not candidates for surgery. The device aims to fix the leak through a less invasive approach, and the study checks if it's safe and works well in daily life.
BudapestAges 18 years+ - NCT06465745Recruiting
AltaValve study for leaky mitral valve
This trial tests a new, less invasive device called the AltaValve to treat a leaky mitral valve. It is for people whose leak is severe enough to cause symptoms, but who cannot have standard surgery or a clip procedure.
Phoenix, ArizonaAges 18 years+ - NCT06467110Enrolling by invitation
Study of SQ-Kyrin TMVr System for leaky mitral valve
This trial tests a new device called the SQ-Kyrin TMVr System to treat severe mitral regurgitation (a leaky heart valve) in people who are not good candidates for traditional open-heart surgery. The goal is to repair the valve without major surgery, using a catheter-based approach.
Shenyang, LiaoningAges 18 years+ - NCT04029363Recruiting
Transcatheter mitral valve procedure for high-surgery-risk patients
This trial studies a newer, catheter-based mitral valve treatment in people with moderate-severe to severe mitral valve leaking who are at high risk for open-heart surgery. It may help improve symptoms and heart function without traditional surgery, but you must meet key heart, anatomy, and safety requirements.
Darlinghurst, New South WalesAges 18 years+ - NCT06414265Recruiting
Testing a new valve for severe mitral regurgitation
This trial tests a new device called the SATURN system, which places a new mitral valve without open-heart surgery. It is for people aged 65 and older with severe mitral regurgitation who are at high risk for surgery.
TbilisiAges 65 years+ - NCT05913908Recruiting
Valve procedure study for severe tricuspid leakage
This trial tests how well a new catheter-based valve system works for people with severe (or worse) tricuspid valve leaking who still have symptoms despite medicines. It aims to improve outcomes by treating the leaking valve without open-heart surgery, if your heart structure and overall health fit the study.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for regurgitation?
- Yes. Clin2 currently lists 200 recruiting regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.