Clinical trials
Regurgitation clinical trials
Below are recruiting regurgitation clinical trials, each written for real people, not researchers. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05848284Recruiting
Tricuspid valve replacement to reduce leaking in the heart
This trial tests a new catheter-based procedure that replaces the tricuspid valve to reduce severe valve leaking. It may help people who still have symptoms despite heart medicines, but only if their heart shape and other health details fit the device requirements.
Los Angeles, CaliforniaAges 18 years+ - NCT05820516Recruiting
Study of a valve treatment for severe leaking tricuspid valve
This trial looks at a catheter-based procedure using the TricValve system for people with severe “tricuspid regurgitation” (a leaky tricuspid valve) who are very symptomatic. It may help reduce the backflow and improve heart function, especially for people who are too unwell for or not helped by standard options.
Pisa, PisaAges 18 years+ - NCT05797519Recruiting
Transcatheter valve replacement for leaking tricuspid valve
This trial studies a catheter-based procedure to replace the tricuspid valve in people with severe valve leakage. It aims to improve symptoms and heart function while tracking safety and effectiveness.
Sydney, New South WalesAges 18 years+ - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT05556460Recruiting
Device trial for fixing severe tricuspid valve leakage without surgery
This trial tests the DragonFly-T system to improve symptoms and heart function in people with severe tricuspid regurgitation (a leaky heart valve) using a catheter-based repair. It may help reduce valve leak–related symptoms when standard medication isn’t enough and surgery risk is higher.
Chengdu, SichuanAges 18 years+ - NCT05496998Recruiting
Heart valve replacement using a catheter for leaking mitral valve
This trial studies a catheter-based procedure to replace the mitral valve in people with severe (or specific moderate) mitral valve leakage that causes symptoms. It may help by reducing leaking and related symptoms when standard surgery or less invasive fixes aren’t suitable for you.
AarhusAges 18 years+ - NCT05438862Recruiting
Early aortic valve surgery versus watchful waiting
This trial compares two approaches for people with a leaking aortic valve but no symptoms: early surgery or careful monitoring (“watchful waiting”). It aims to see which strategy better prevents future heart problems and when surgery is most helpful.
AalstAges 18 years+ - NCT05090540Enrolling by invitation
Less Invasive vs Usual Surgery for Mitral Valve Leaks
This trial compares a less invasive catheter procedure to the standard surgical operation to treat “secondary” leaking of the mitral valve. It may help people with significant valve leak decide which approach works better for reducing symptoms and heart strain.
Saint-DenisAges 18–90 - NCT04761120Recruiting
Follow-up study for specific heart valve repair ring implants
This study follows people who are going to get certain types of heart valve repair rings or bands. It aims to track safety and outcomes after the Abbott device is implanted in routine care over follow-up visits.
Durham, North CarolinaAges 18 years+ - NCT04093297Enrolling by invitation
Band vs ring surgery for tricuspid valve leakage
This trial compares two surgical options (a band versus a ring) to treat tricuspid valve regurgitation, which means blood leaks backward through the tricuspid valve. It may help your heart work more efficiently and reduce symptoms by testing which device works better for people with the right valve problem.
Nanjing, JiangsuAges 18–70 - NCT03389542Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
AmiensAges 18–75 - NCT03242642Recruiting
Testing a new catheter procedure to replace a leaking mitral valve
This trial studies whether a new catheter-based system can replace a badly leaking mitral valve in people who have symptoms. It may help if you can’t safely get current approved valve treatments or standard surgery.
Birmingham, AlabamaAges 18 years+ - NCT06075823Recruiting
Mitral valve repair for heart failure with ATTR amyloidosis
This trial tests a clip procedure to fix a leaky heart valve in people who also have a heart condition called ATTR-CM, which can cause heart failure. The clip is placed without open-heart surgery to help improve symptoms and quality of life.
GrazAges 18 years+ - NCT03416166Recruiting
Registry for people getting a heart valve procedure
This study collects information about people who are having a transcatheter tricuspid valve procedure (a heart valve treatment done through catheters rather than open-heart surgery). It may help doctors understand safety and outcomes better over time.
ZurichAges 18–99 - NCT02033811Recruiting
MitraClip registry for severe leaky mitral valve
This registry study follows people who have a severely leaky mitral heart valve and receive MitraClip, a procedure that repairs the valve through the skin. It helps doctors learn how well this treatment works over time for different patients.
DüsseldorfAges 18 years+ - NCT04190602Recruiting
Registry study for NeoChord artificial mitral valve chord
This study keeps track of people who had NeoChord treatment to help understand how well it works in everyday care. You may be included if you had a certain type of mitral valve leakage (regurgitation) and the procedure happened after 2016.
BonnAges 18 years+ - NCT02996552Recruiting
Ring repair for mild-to-moderate leaky right valve
This trial looks at whether adding a specific repair to the right valve (called tricuspid annuloplasty) during mitral valve surgery helps people whose right valve leakage is not severe. It compares doing the extra right-valve repair versus doing only the mitral valve repair.
Rozzano, MilanoAges 18 years+ - NCT02537769Recruiting
Surgery to fix a leaky tricuspid valve in LVAD patients
This study looks at whether fixing a mildly leaky tricuspid valve during LVAD surgery improves outcomes for people with advanced heart failure. It’s mainly aimed at patients who are already scheduled to receive an implantable LVAD.
Seattle, WashingtonAges 18 years+ - NCT04898335Recruiting
Tendyne heart valve registry for real-world patient experiences
This registry collects information from people who received the Tendyne mitral valve in routine care. It helps doctors understand how the valve performs in everyday practice and may guide future care.
LinzAges 18 years+ - NCT05040074Recruiting
Transcatheter repair for leaking mitral valve in high-risk patients
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Shenyang, LiaoningAges 18 years+ - NCT04890821Recruiting
Percutaneous ring repair for leaking tricuspid valve
This early study tests a minimally invasive device that helps tighten (repair) the tricuspid valve ring to reduce severe leaking. It may help people who still have symptoms from right-sided heart failure even after taking the best available medicines.
Hackensack, New JerseyAges 18 years+ - NCT05194423Recruiting
LuX-Valve procedure for severe leaking tricuspid valve
This trial tests a minimally invasive procedure (LuX-Valve placed through a neck vein) to treat severe leaking of the tricuspid valve. It may help people who are too high-risk for open-heart tricuspid surgery.
Beijing, Beijing MunicipalityAges 50 years+ - NCT04775108Recruiting
Testing a new heart procedure for severe leaking mitral valve
This trial studies a new transcatheter (through the heart without open surgery) mitral valve treatment for people with severe mitral valve leaking who are too high-risk for standard surgery. It may help reduce valve leakage and improve symptoms, but it’s an early “first-in-human” device study.
InnsbruckAges 60 years+ - NCT05179616Recruiting
Study of TriClip treatment for severe leaky tricuspid valve
This study follows adults with a severely leaky tricuspid heart valve who still have symptoms despite medication. It looks at outcomes after a procedure called TriClip, which helps reduce valve leakage.
PforzheimAges 18 years+
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Common questions
- Are there clinical trials for regurgitation?
- Yes. Clin2 currently lists 200 recruiting regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.