Clinical trials
Regurgitation clinical trials
Below are recruiting regurgitation clinical trials, each written for real people, not researchers. We’re tracking 199 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06569602Recruiting
EVOQUE valve study for leaky tricuspid valve
This study is testing a new way to replace the tricuspid valve (the valve that controls blood flow from the heart's right upper chamber to the right lower chamber) without open-heart surgery. The goal is to see how safe and effective the EVOQUE valve is for people with a leaky tricuspid valve.
Bad BerkaAges Any age - NCT06518681Enrolling by invitation
Testing a new polymer heart valve for aortic disease
This trial tests a new type of artificial heart valve made of polymer (a special plastic-like material) for people with severe aortic valve disease. It aims to see if the valve is safe and works well, giving you an option for a replacement valve that might last longer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06506942Recruiting
TRICURE device study for leaky heart valve
This study tests a new device to help people with severe tricuspid regurgitation (leaky heart valve) who are at higher risk from surgery. It aims to see if the device can reduce the leak and improve symptoms.
Atlanta, GeorgiaAges 18 years+ - NCT06255457Recruiting
Heart rhythm study for patients getting mitral valve surgery
This study looks at heart rhythm problems in people having mitral valve surgery to fix a leaky valve. It may help doctors better understand who is at risk for dangerous rhythms.
Stockholm, Stockholm CountyAges 18 years+ - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06282042Recruiting
Early Fix of Leaky Mitral Valve After Heart Attack
This trial tests an early, minimally invasive procedure to fix a leaky mitral valve using a catheter (a thin tube) after a heart attack. The goal is to see if fixing the valve early can help patients recover better and avoid more serious heart problems.
Afula, AfulaAges 18–99 - NCT06241430Recruiting
CardioClip study: testing a new valve repair for leaky heart valve
This study tests a new clip procedure (CardioClip) to repair a leaky mitral valve in people with heart failure. It aims to see if the clip can improve symptoms and heart function.
New York, New YorkAges 18–90 - NCT06183684Recruiting
Study of a new tricuspid valve replacement for severe leakage
This study tests a new, less invasive way to replace the tricuspid valve (the valve between the right upper and lower heart chambers) in people with severe leakage. The valve is delivered through a vein in the neck or leg, avoiding open-heart surgery.
Tucson, ArizonaAges 18–90 - NCT06113354Recruiting
Testing the MRace implant for leaky heart valve repair
This trial tests a new device called MRace that may fix a leaky mitral valve without open-heart surgery. It's for people whose valve leaks severely and who can't have standard surgery due to other health issues.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT05965258Recruiting
Classify mitral regurgitation using heart scans
This study uses heart imaging to better understand different types of mitral valve leak (mitral regurgitation) and how it relates to heart pumping function. Results may help doctors match people to the most appropriate care based on scan “patterns.”
Cleveland, OhioAges 18 years+ - NCT06038838Recruiting
Tioga TMVR system feasibility study for mitral regurgitation
This trial tests a new device called the Tioga TMVR system to treat moderate to severe mitral regurgitation (leaky heart valve). It is for people who cannot have standard surgery or other less invasive treatments.
São PauloAges 18 years+ - NCT06033274Recruiting
Global registry for tricuspid valve replacement
This study is a registry that collects data on patients who receive a new type of heart valve replacement for the tricuspid valve through a less invasive catheter procedure. Joining helps doctors learn more about how well this treatment works in real-world patients.
Phoenix, ArizonaAges 18 years+ - NCT05976165Recruiting
Breath testing study for small bowel bacterial overgrowth
This study checks whether breath tests can help identify small intestinal bacterial overgrowth in people with reflux-like symptoms (heartburn or regurgitation). If you qualify, you may be asked to avoid certain medicines and treatments for a short time so the test results are accurate.
Jacksonville, FloridaAges 18 years+ - NCT04905017Recruiting
Transcatheter valve treatment study for severe tricuspid valve leakage
This study tests a new, catheter-based procedure to treat moderate-to-severe leaking of the tricuspid valve (a heart valve on the right side). It’s for people who are high surgical risk and might benefit from replacing the valve without open-heart surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT05825898Enrolling by invitation
Treatment outcomes for severe leaking tricuspid valve
This study looks at what happens to adults with moderate-to-severe or severe tricuspid valve “leaking” after different treatment types, such as catheter-based or surgery. It may help doctors understand which approach works best for people with severe valve leakage and symptoms.
Rochester, MinnesotaAges 18 years+ - NCT05459233Recruiting
Testing ultrasound-guided valve settings after valve-in-valve TAVR
This trial compares two ways to check and fine-tune how well a new valve is working after a “valve-in-valve” TAVR procedure. It looks to see whether measurements from ultrasound of the heart (Doppler echocardiography) match results from a catheter test, which could help guide safer, more accurate valve care.
San Francisco, CaliforniaAges 18 years+ - NCT05298124Recruiting
Repairing a leaking mitral valve in severe heart shock
This trial tests a catheter-based procedure to repair a leaking mitral valve in people who are in severe heart shock and need medication support. The goal is to reduce the valve leak and see if it helps patients stabilize and recover.
Rochester, MinnesotaAges 18 years+ - NCT05305612Enrolling by invitationPhase 4
Blood thinners during heart valve or left atrial appendage procedures
This study compares different ways of using blood thinners during procedures to fix a leaky mitral valve or close the left atrial appendage. The goal is to find the safest approach to prevent strokes and bleeding.
GdanskAges 18 years+ - NCT05061004Recruiting
Cephea valve study for severe mitral valve disease
This study tests a new device called the Cephea valve, which is placed through a small tube (catheter) to treat severe leaking or narrowing of the mitral valve. It may be an option for people who are not good candidates for open-heart surgery.
Phoenix, ArizonaAges 18 years+ - NCT04919980Recruiting
Testing a new mitral valve repair device for high-surgery-risk patients
This study looks at a new way to treat a leaky mitral heart valve using the INNOVALVE system. It’s meant for people who have symptoms from mitral regurgitation but are considered high risk for open-heart surgery, to see if the approach can help safely.
Los Angeles, CaliforniaAges 18 years+ - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT04688190Recruiting
Registry study for choosing a mitral valve treatment
This study collects and compares real-world results to help doctors choose the best treatment for mitral valve “leakiness.” If you have clinically significant mitral insufficiency and have already had a specific heart procedure screening, your echocardiogram results may be used to understand outcomes over at least a month.
Tucson, ArizonaAges 18 years+ - NCT04734756Enrolling by invitation
Dragonfly device study for leaking mitral valve in high-risk patients
This trial tests the safety and effectiveness of a heart procedure that repairs a leaking mitral valve through thin tubes, using the Dragonfly system. It’s for people who have significant mitral valve leak symptoms but are considered high risk for open-heart surgery.
Hangzhou, ZhejiangAges 18 years+ - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90
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Common questions
- Are there clinical trials for regurgitation?
- Yes. Clin2 currently lists 199 recruiting regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.