Clinical trials
Respiratory Failure clinical trials
Below are recruiting respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 209 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06795971Recruiting
Comparing oxygen methods for hypoxemic respiratory failure
This trial compares three ways of giving extra oxygen to people with low blood oxygen levels: a face mask with continuous pressure, a noninvasive ventilator, or high-flow oxygen through the nose. The goal is to see which method helps people avoid needing a breathing tube.
Nanjing, JiangsuAges 18 years+ - NCT06051292Recruiting
Testing balloon size for lung pressure measurement in children
This study tests how much air to put in a small balloon in the esophagus (feeding tube-like device) to measure lung pressure more accurately. It is for children on a breathing machine whose settings are stable for the next 2 hours.
AydinAges 1 month–18 years - NCT05026749RecruitingPhase 3
Azithromycin for severe RSV breathing failure in young children
This trial tests whether azithromycin (an antibiotic) can improve outcomes for babies and young children in the ICU who have RSV causing serious breathing problems. It mainly looks at children who start strong breathing support soon after RSV symptoms begin.
Birmingham, AlabamaAges 3 days–2 years - NCT06213168Recruiting
CPAP plus high-flow oxygen vs oxygen alone for breathing failure
This study tests whether adding a breathing machine (CPAP) to high-flow oxygen can help people with sudden breathing failure more than high-flow oxygen alone. It is for adults recently admitted to the ICU with low oxygen levels.
AmiensAges 18 years+ - NCT06464224Recruiting
Breathing effort patterns in patients coming off the ventilator
This study observes how your breathing effort changes as doctors try to remove you from the breathing machine (ventilator). It helps understand why some patients have trouble breathing on their own after being on the ventilator.
Rio de JaneiroAges 18 years+ - NCT04524585Recruiting
Tested a muscle-relaxing treatment for severe low-oxygen breathing
This study tests whether partially relaxing the breathing-related muscles can help people with severe low oxygen while they are on a breathing machine. It may improve how well the lungs work by changing the way the muscles affect breathing.
Toronto, OntarioAges 18 years+ - NCT06510972Recruiting
Eating versus fasting for ICU patients with breathing failure
This study looks at whether it's safe and helpful to let people with severe breathing problems in the ICU eat and drink normally instead of fasting. If you qualify, you may be assigned to either continue eating or to fast while doctors monitor your recovery.
BloisAges 18 years+ - NCT07334457Recruiting
Platelet Changes While on ECMO Support
This study looks at how blood cells called platelets change in people who are on a heart-lung machine (ECMO) in the ICU. It aims to better understand how the body responds to this support.
StrasbourgAges 18 years+ - NCT06446453Recruiting
Lung Ultrasound-Guided Surfactant For Preterm Infants
This study tests whether giving surfactant medication guided by a lung ultrasound, instead of by X-ray, helps preterm babies with breathing problems get better without needing a breathing tube. Babies in the study receive surfactant through a thin tube while still on non-invasive breathing support.
Hartford, ConnecticutAges birth–2 hours - NCT07119411Recruiting
Early ICU Warning System for Deterioration
This trial tests a system that gives ICU staff an early alert when a patient's condition might get worse. If you are already in the ICU, the study uses your medical data to see if the alert can help catch problems sooner.
BernAges 18 years+ - NCT07686315Recruiting
Safer breathing with advanced monitoring on a ventilator
This trial is testing a new way to monitor your breathing while you are on a ventilator, to make it safer. It is for people who need a ventilator for reasons other than lung failure, like after a coma, injury, or severe infection.
Milan, LombardyAges 18 years+ - NCT06750536Recruiting
Safety study of a new lung support device for small children
This trial is testing a new device (MiniLung Petite Kit) for babies and young children with severe lung or heart failure. The device helps oxygenate the blood and remove carbon dioxide, giving the lungs and heart a chance to rest and heal.
Bonn, North Rhine-WestphaliaAges Up to 8 months - NCT05731024Recruiting
Closed-loop breathing control vs standard care for kids in ICU
This study compares a computerized “closed-loop” system that helps match breathing support to a child’s needs versus usual (standard) breathing control. It’s for critically ill children on a breathing machine, aiming to improve synchronization between the child and the ventilator.
AydinAges 1 month–18 years - NCT06494085Recruiting
Finding the right breathing support for ICU patients
This study looks at how to better adjust breathing machines for people in the ICU who have low oxygen levels. It tests a new way to measure if the machine is doing too much of the work, which could help tailor support and make breathing easier.
Toronto, OntarioAges 18 years+ - NCT06936618Recruiting
Electrical impedance guided ventilator settings for breathing failure
This trial tests whether using electrical impedance tomography (EIT), a safe and non-invasive monitoring technique, helps doctors set the ventilator better for patients with low oxygen levels. It may improve your breathing support during mechanical ventilation.
BangkokAges 18 years+ - NCT07542366Recruiting
Testing a new lung imaging method in ICU patients
This study tests whether a special imaging technique called EIT (electrical impedance tomography) combined with a safe contrast injection can measure blood flow in the lungs of patients on breathing machines. If it works, it could help doctors better manage critically ill patients.
Wuhu, AnhuiAges 18 years+ - NCT06066502RecruitingPhase 3
Precision ventilation for ARDS
This study tests whether a customized breathing machine approach ("precision ventilation") is better than usual care for patients with ARDS. The goal is to improve oxygen levels and recovery while avoiding lung damage.
Tucson, ArizonaAges 18 years+ - NCT07672106Recruiting
Predicting breathing tube need after major surgery recovery
This study watches patients after major surgery to see which factors may increase the chance of needing a breathing tube again. It helps doctors better predict and prevent breathing problems in the intensive care unit.
Istanbul, ŞişliAges 18 years+ - NCT05990348Recruiting
Comparing two breathing support methods for weaning from ventilator
This study compares two ways of helping patients breathe on a ventilator after a failed attempt to come off the machine. It looks at how the diaphragm and rib muscles work during each method to find the best approach for weaning.
RomeAges 18 years+ - NCT06203405Recruiting
Sedation guided by breathing effort in ICU patients
This trial tests a new way to manage sedation (medication to keep you calm and comfortable) for people on a breathing machine. The goal is to see if adjusting sedation based on your breathing effort leads to better outcomes and shorter time on the machine.
Bangkok, BangkokAges 18 years+ - NCT06774534Recruiting
SerpinB3 protein in acute respiratory distress
This study looks at a protein called SerpinB3 and its role in severe lung inflammation (ARDS). It may help doctors understand how ARDS develops and find new ways to treat it.
Padova, PDAges 18 years+ - NCT06424314Recruiting
Trial on why some patients fail to come off a ventilator
This trial is studying why some people have trouble coming off a breathing machine (ventilator). It's for patients who've been on a ventilator for at least 2 days and don't have certain other conditions.
Guangzhou, GuangdongAges 18 years+ - NCT03515031Recruiting
Compare two oxygen masks for breathing failure from pneumonia
This trial compares two ways of giving oxygen—high-flow nasal tubes versus a Venturi face mask—for adults with pneumonia causing acute breathing failure. It aims to see which method works better to improve breathing and recovery.
BergamoAges 18 years+ - NCT03667027Recruiting
Study of breathing muscle and lung changes during transplant planning
This trial studies how the diaphragm (your main breathing muscle) and lung/airway tissue behave in people who are being supported until they can get a lung transplant. The results may help doctors better understand breathing failure and improve transplant care.
TorontoAges 18 years+
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Common questions
- Are there clinical trials for respiratory failure?
- Yes. Clin2 currently lists 209 recruiting respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.