Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07568301Enrolling by invitation
Music and nature self-care for brain injury survivors
This study explores whether music and nature-based activities can help people who have experienced brain injuries (like stroke or traumatic brain injury) and their caregivers manage stress and improve wellbeing. You and a care partner would participate together in the program.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07109804Recruiting
Deep brain stimulation to improve walking after spinal cord injury
This study tests whether stimulating a small area deep in the brain (the cuneiform nucleus) with a device called deep brain stimulation (DBS) can help people walk better after a spinal cord injury. The goal is to see if it improves walking speed and stability.
Miami, FloridaAges 22–70 - NCT07135791Recruiting
Tracking daily fatigue in adults with brain injury or cerebral palsy
This study uses a smartphone app to track how fatigue changes throughout the day in adults with cerebral palsy or acquired brain injury. The goal is to better understand fatigue patterns so doctors can offer better support.
Glostrup MunicipalityAges 30–65 - NCT07548580Recruiting
Early Movement Therapy for Brain Injury in Hospital ICU
This study looks at how gentle, early physical movement during ICU care affects recovery in patients with serious brain injuries like stroke or head trauma. Researchers will track how patients respond to a structured movement program while they're on a breathing machine.
CopenhagenAges 18 years+ - NCT06624488Recruiting
Brain injury markers after cardiac arrest and outlook
This study looks at certain proteins in the fluid around the brain and in the blood after a cardiac arrest. These proteins may help doctors predict how the patient will recover, which could guide their care.
BeijingAges 18–80 - NCT06247904Enrolling by invitation
Brain stimulation for arm paralysis after spinal cord injury
This study tests a noninvasive brain stimulation method (NIBS) to help people with recent spinal cord injuries regain arm and hand function. It is designed for patients who have some paralysis in their arms but still have some movement or sensation below their injury level.
Elkins Park, PennsylvaniaAges 18–80 - NCT04474106Recruiting
Shock wave therapy for new spinal cord injuries
This study tests whether extracorporeal shock wave therapy (non-surgical shock waves delivered from outside the body) can improve movement and sensation after a recent spinal cord injury. It may help people recover motor (movement) and sensory (feeling) function within months after injury.
Innsbruck, TyrolAges 18–99 - NCT05343130Recruiting
Brain-controlled electrical therapy for arm mobility after spinal injury
This trial studies a brain-computer system that helps control electrical stimulation to improve arm movement after a spinal cord injury. It may help with functional use of the upper limbs during rehabilitation if you meet the specific injury, spasticity, and safety requirements.
Tlalpan, Mexico CityAges 18 years+ - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT03053791Recruiting
Deep brain stimulation to improve walking after incomplete spinal injury
This study tests whether deep brain stimulation can improve walking in people with an incomplete spinal cord injury. It also requires that you meet specific injury and walking ability requirements and be able to attend study visits and training.
ZurichAges 18–75 - NCT07280351Enrolling by invitation
Duraplasty for acute spinal cord injury
This trial tests whether adding a special patch (duroplasty) during emergency spinal surgery helps people recover from a recent traumatic spinal cord injury. It's for patients who need decompression surgery within 24 hours of injury.
San Francisco, CaliforniaAges 18–80 - NCT01459107RecruitingPhase 2
Upper arm transplant study using immune treatment
This trial tests replacing a missing or non-working lower arm/hand with a donated upper limb (transplant). It also uses a special immune treatment plan and bone marrow infusion to help the body accept the new limb, aiming to improve hand function and quality of life.
Baltimore, MarylandAges 18–69 - NCT06451133Recruiting
Blood pressure management after traumatic spinal cord injury
This study tests a way to manage blood pressure after a traumatic spinal cord injury. It aims to improve blood flow to the injured area and help recovery.
Houston, TexasAges 18 years+ - NCT04696523RecruitingPhase 2
Xenon gas for brain injury after a ruptured brain aneurysm
This Phase 2 study tests whether xenon gas can reduce brain injury after an aneurysmal subarachnoid hemorrhage (a bleeding caused by a brain aneurysm). It aims to help people who are very sick right after the bleeding by improving brain function outcomes.
Helsinki, HelsinkiAges 18 years+ - NCT05380050Recruiting
Telehealth vs in-person skills training for brain injury and PTSD
This study compares a combined skills program delivered by video/phone (telehealth) versus meeting in person. It aims to improve attention and coping skills for veterans who have both mild brain injury and PTSD.
Gainesville, FloridaAges 30–55 - NCT06707441Recruiting
Comparing two scores to predict chest injury outcomes
This study tests two different scoring systems (TTSS and TISS) to see which better predicts recovery in people with chest injuries like broken ribs, lung bruises, or collapsed lungs. Doctors use these scores soon after you arrive to guide treatment and predict how you'll do.
BaghdadAges 16 years+ - NCT06979466Recruiting
Electrical device for chronic stroke recovery
This trial tests a device that uses electrical stimulation to help people who had a stroke several months to years ago improve arm and hand movement. You would use the device while sitting and do physical exercises with help from a caregiver.
White Plains, New YorkAges 18–80 - NCT07248995Recruiting
Ultrasound to set breathing support in brain injury patients with lung issues
This trial tests if chest and head ultrasound can help doctors adjust the breathing machine (PEEP) for patients with both a severe brain injury and a serious lung condition called ARDS. The goal is to improve care without harming the brain.
ThessalonikiAges 18 years+ - NCT07065916Enrolling by invitation
Arm More + Camp: Helping kids with arm weakness
This trial tests a program called 'Arm More + Camp' to help kids and teens with arm weakness due to cerebral palsy or a brain injury improve their movement. It’s a group camp-style study that fits into the school year.
Calgary, AlbertaAges 5–17 - NCT02395497RecruitingPhase 2/Phase 3
Penile transplant trial using immune-suppressing medicines
This study tests whether a donated penis can be successfully transplanted using medicines that calm the immune system to prevent rejection. It also looks at safety and recovery of function in men with severe penile loss from injury, cancer surgery, or birth conditions.
Baltimore, MarylandAges 18–69 - NCT07472985Recruiting
Early cycling exercise after spinal cord injury
This trial tests if starting leg cycling exercise within the first week after spinal cord injury is safe and helpful. It is for adults who had surgery within 48 hours of their injury and have a specific level of paralysis.
Montreal, QuebecAges 18 years+ - NCT06127316Recruiting
Heel lift height and foot pressure with custom braces
This study tests if changing the height of a heel lift in a custom foot brace can improve how weight is distributed on your foot after a serious ankle or hindfoot injury. If you have pain when walking, this could help find better ways to reduce that pain.
Iowa City, IowaAges 18–65 - NCT06111976Recruiting
TMS plus reactivation therapy for resistant PTSD
This trial tests if adding a type of brain stimulation (TMS) to a memory reactivation therapy can reduce PTSD symptoms that haven't improved with standard antidepressants. If you have persistent PTSD, this study could offer a new treatment option.
ParisAges 18–65 - NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 226 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.