Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 234 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06148324Recruiting
Wellness program for traumatic brain injury recovery
This study tests a wellness program for people who had a moderate or severe traumatic brain injury (TBI) at least a year ago. The program is done online, so you can join from home, and it aims to help you with your recovery and well-being.
New York, New YorkAges 18–70 - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT05683145Recruiting
Better sleep for people with moderate or severe TBI
This trial studies an approach to improve insomnia (trouble falling or staying asleep) in people who had a moderate-to-severe traumatic brain injury at least one year ago. If you qualify, it may help you restore more regular, efficient sleep after TBI.
Aurora, ColoradoAges 18–60 - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT04445649Recruiting
Find factors to help people regain consciousness after brain injury
This study looks at what predicts recovery of consciousness after certain serious brain injuries, such as stroke or traumatic brain injury. It may help clinicians better identify which patients are more likely to wake up and guide early rehabilitation and care.
Hessisch OldendorfAges 18–85 - NCT04043442Enrolling by invitationPhase 2
Brain stimulation study for alcohol use with mild brain injury
This trial tests a type of brain stimulation to help with day-to-day functioning in people who have alcohol use disorder and a history of mild traumatic brain injury. It also uses brain and symptom testing to see who may benefit most and why.
Hines, IllinoisAges 22–65 - NCT06988787Recruiting
Resilience therapy for veterans after trauma
This study tests a program to help female veterans who have experienced intimate partner violence or military sexual trauma and have stress symptoms. It aims to improve emotional well-being and resilience.
Houston, TexasAges 18 years+ - NCT07568301Enrolling by invitation
Music and nature self-care for brain injury survivors
This study explores whether music and nature-based activities can help people who have experienced brain injuries (like stroke or traumatic brain injury) and their caregivers manage stress and improve wellbeing. You and a care partner would participate together in the program.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07109804Recruiting
Deep brain stimulation to improve walking after spinal cord injury
This study tests whether stimulating a small area deep in the brain (the cuneiform nucleus) with a device called deep brain stimulation (DBS) can help people walk better after a spinal cord injury. The goal is to see if it improves walking speed and stability.
Miami, FloridaAges 22–70 - NCT07858708Enrolling by invitation
Vision problems after brain injury
This study looks at vision problems that can happen after a brain injury, like a stroke, traumatic brain injury, or brain tumor. The researchers want to understand how these vision issues affect daily life, which could help improve care.
Prague, Česká RepublikaAges 18–85 - NCT07135791Recruiting
Tracking daily fatigue in adults with brain injury or cerebral palsy
This study uses a smartphone app to track how fatigue changes throughout the day in adults with cerebral palsy or acquired brain injury. The goal is to better understand fatigue patterns so doctors can offer better support.
Glostrup MunicipalityAges 30–65 - NCT07548580Recruiting
Early Movement Therapy for Brain Injury in Hospital ICU
This study looks at how gentle, early physical movement during ICU care affects recovery in patients with serious brain injuries like stroke or head trauma. Researchers will track how patients respond to a structured movement program while they're on a breathing machine.
CopenhagenAges 18 years+ - NCT06624488Recruiting
Brain injury markers after cardiac arrest and outlook
This study looks at certain proteins in the fluid around the brain and in the blood after a cardiac arrest. These proteins may help doctors predict how the patient will recover, which could guide their care.
BeijingAges 18–80 - NCT06247904Enrolling by invitation
Brain stimulation for arm paralysis after spinal cord injury
This study tests a noninvasive brain stimulation method (NIBS) to help people with recent spinal cord injuries regain arm and hand function. It is designed for patients who have some paralysis in their arms but still have some movement or sensation below their injury level.
Elkins Park, PennsylvaniaAges 18–80 - NCT04474106Recruiting
Shock wave therapy for new spinal cord injuries
This study tests whether extracorporeal shock wave therapy (non-surgical shock waves delivered from outside the body) can improve movement and sensation after a recent spinal cord injury. It may help people recover motor (movement) and sensory (feeling) function within months after injury.
Innsbruck, TyrolAges 18–99 - NCT05343130Recruiting
Brain-controlled electrical therapy for arm mobility after spinal injury
This trial studies a brain-computer system that helps control electrical stimulation to improve arm movement after a spinal cord injury. It may help with functional use of the upper limbs during rehabilitation if you meet the specific injury, spasticity, and safety requirements.
Tlalpan, Mexico CityAges 18 years+ - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT03053791Recruiting
Deep brain stimulation to improve walking after incomplete spinal injury
This study tests whether deep brain stimulation can improve walking in people with an incomplete spinal cord injury. It also requires that you meet specific injury and walking ability requirements and be able to attend study visits and training.
ZurichAges 18–75 - NCT07280351Enrolling by invitation
Duraplasty for acute spinal cord injury
This trial tests whether adding a special patch (duroplasty) during emergency spinal surgery helps people recover from a recent traumatic spinal cord injury. It's for patients who need decompression surgery within 24 hours of injury.
San Francisco, CaliforniaAges 18–80 - NCT01459107RecruitingPhase 2
Upper arm transplant study using immune treatment
This trial tests replacing a missing or non-working lower arm/hand with a donated upper limb (transplant). It also uses a special immune treatment plan and bone marrow infusion to help the body accept the new limb, aiming to improve hand function and quality of life.
Baltimore, MarylandAges 18–69 - NCT06451133Recruiting
Blood pressure management after traumatic spinal cord injury
This study tests a way to manage blood pressure after a traumatic spinal cord injury. It aims to improve blood flow to the injured area and help recovery.
Houston, TexasAges 18 years+ - NCT04696523RecruitingPhase 2
Xenon gas for brain injury after a ruptured brain aneurysm
This Phase 2 study tests whether xenon gas can reduce brain injury after an aneurysmal subarachnoid hemorrhage (a bleeding caused by a brain aneurysm). It aims to help people who are very sick right after the bleeding by improving brain function outcomes.
Helsinki, HelsinkiAges 18 years+
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 234 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.