Clinical trials · North Carolina
Stroke clinical trials in North Carolina
We’re tracking 31 recruiting stroke studies with a site in North Carolina — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06765642Recruiting
Brain stimulation for hand strength after stroke
This study tests whether a safe, non-invasive brain stimulation technique (called rTMS) can improve hand strength and movement in people who have had a stroke at least 3 months ago. The treatment is delivered through a coil placed on the scalp and does not require surgery.
Durham, North CarolinaAges 21 years+ - NCT05338697Recruiting
Early testing after stroke to predict recovery outcomes
This study checks early brain and arm/hand signals soon after a stroke to better predict how well people recover by about 90 days. It may help future, better-targeted stroke recovery studies by improving how recovery chances are measured early.
Durham, North CarolinaAges 18 years+ - NCT07098286Enrolling by invitation
Home rehab after stroke
This study tests a high-intensity home-based rehabilitation program for people who have had a stroke. It aims to help you recover strength and function in the comfort of your own home.
Durham, North CarolinaAges 18 years+ - NCT05691244RecruitingPhase 3
Tested drug for acute ischemic stroke within 24 hours
This Phase 3 trial studies sovateltide (and a placebo) in adults with an ischemic stroke, aiming to improve safety and outcomes. It focuses on people who can start treatment quickly after stroke symptoms begin and who do not have bleeding in the brain on imaging.
Greensboro, North CarolinaAges 18–80 - NCT07220005Recruiting
Focused ultrasound for stroke recovery
This study tests a gentle sound wave therapy (focused ultrasound) to see if it can help improve arm movement in people who had a stroke at least 6 months ago. It aims to find the best settings for this treatment.
Durham, North CarolinaAges 21 years+ - NCT07050355Recruiting
Brain stimulation and exercise for depression after stroke
This study tests whether combining brain stimulation with aerobic exercise can help treat depression and improve walking in people who have had a stroke at least a year ago. If you have ongoing depressive symptoms and some leg weakness from your stroke, this treatment may help you feel better and walk more easily.
Durham, North CarolinaAges 21 years+ - NCT03821129Recruiting
Reduce recurrent stroke with a PFO closure device and antiplatelet pills
This study looks at whether closing a heart opening called a patent foramen ovale (PFO) with a special septal occluder, along with antiplatelet medications, can lower the risk of another stroke. It is for people who recently had a stroke thought to be caused by a clot that traveled from the heart but without another clear source.
Charlotte, North CarolinaAges 18–70 - NCT04908423RecruitingPhase 4
Xeomin to improve walking after stroke
This trial tests Xeomin (a type of botulinum toxin) to improve walking and leg mobility after stroke-related muscle stiffness. It’s for people who have spasticity (tight, stiff muscles) that affects how they clear their toes during walking.
Charlotte, North CarolinaAges 18–79 - NCT04916210Recruiting
Study how stroke type affects thinking and recovery
This study looks at what predicts memory and thinking problems after different types of stroke or brain bleeding, and how blood-vessel changes relate to recovery. You may be invited if you recently had a stroke/bleed and can complete a baseline check within 6 weeks.
Winston-Salem, North CarolinaAges 18 years+ - NCT04994756Recruiting
Stroke and brain blood-vessel procedure registry study
This study collects information from people who undergo a procedure for a problem in brain or blood vessels (such as stroke-related vessel blockage). It does not test a new drug; it helps doctors understand outcomes and care patterns after these procedures.
Raleigh, North CarolinaAges 1–120 - NCT05611242RecruitingPhase 3
Thrombectomy for acute stroke caused by blocked neck and brain arteries
This Phase 3 trial studies whether removing a clot using a catheter (endovascular thrombectomy) works better for certain types of acute ischemic stroke. It focuses on people with a blocked neck artery plus a blockage in the brain, and who can’t get or didn’t respond to IV clot-busting medicine.
Winston-Salem, North CarolinaAges 18–79 - NCT05948566RecruitingPhase 2
Improving response to stroke treatment with an antibody drug
This Phase 2 trial tests an antibody treatment (TS23) given to people with a suspected acute ischemic stroke to improve how well they respond to stroke care. You may qualify if your stroke scan shows the right pattern of injured brain tissue and if the study drug can be given within a short time window after symptoms start.
Durham, North CarolinaAges 18 years+ - NCT06226805RecruitingPhase 2
Testing BB-031 for recent ischemic stroke
This study tests an experimental drug called BB-031 to see if it can safely help people who have had a recent ischemic stroke (a clot that blocks blood flow to the brain). The trial is for people who can get to the hospital within 24 hours of their first symptoms and have a moderate to severe stroke.
Raleigh, North CarolinaAges 18 years+ - NCT07638462Recruiting
Early mobility recovery program after acute stroke
This study tests whether early movement and physical activity help stroke patients recover better mobility. You'd be in the hospital after a recent stroke, and the team would work with you on safe movement and exercises during your recovery.
Winston-Salem, North CarolinaAges 18 years+ - NCT06386874Recruiting
Magnetic field therapy for arm recovery after stroke
This study tests a new magnetic device applied to the head to help improve arm function after a stroke. You will use the device while doing exercises, and a caregiver will support you with a mobile app and video calls.
Charlotte, North CarolinaAges 22–80 - NCT06440707RecruitingPhase 2
Brain stimulation for recent stroke recovery
This trial tests a safe, non-invasive brain stimulation technique called tDCS to help people recover from a recent stroke. It's for people who cannot have the standard clot-removal procedure and who can start treatment within 24 hours of their stroke.
Durham, North CarolinaAges 18 years+ - NCT06682429Recruiting
Home rehab program after stroke
This study tests a home-based therapy program delivered by video calls to help people recovering from a stroke improve arm function. It is designed for those with moderate arm weakness about 4 months after their stroke.
Chapel Hill, North CarolinaAges 18–80 - NCT06759558RecruitingPhase 2
Zuranolone for post-stroke depression
This trial tests a new medicine called zuranolone (allopregnanolone) for people with depression after a stroke. It aims to see if the drug can help improve mood when taken over a short period.
Durham, North CarolinaAges 21–65 - NCT07121582Recruiting
Brain rhythm training for arm recovery after stroke
This trial tests a way to retrain your brain's rhythms after a stroke to help you move your arm and hand better. It uses a non-invasive head coil (TMS) to stimulate the brain while you squeeze a grip device.
Chapel Hill, North CarolinaAges 45–80 - NCT00682695Recruiting
Study genetic and environmental risks for brain bleeding stroke
This study looks at how genes and life factors may contribute to a type of stroke caused by bleeding in the brain. You may be eligible if you’ve had a spontaneous (not caused by injury or infection) brain bleed and can complete consent, interviews, blood pressure checks, and a DNA sample.
Durham, North CarolinaAges 18 years+ - NCT07460804Recruiting
Sit to stand study for chronic stroke survivors
This trial tests a specific exercise to help people who had a stroke more than 6 months ago improve their ability to stand up from a chair. It may help you if you have some trouble but can still do the movement with minimal or no help.
Cullowhee, North CarolinaAges 18 years+ - NCT06781385Enrolling by invitationPhase 2
Tenecteplase after clot removal for severe stroke
This trial tests if giving a clot-busting drug (tenecteplase) directly into the brain artery after a successful clot-removal procedure can improve outcomes for people with a major stroke. It is for patients who had a large vessel blockage and received endovascular thrombectomy within 24 hours of symptoms starting.
Charlotte, North CarolinaAges 18 years+ - NCT07143019Recruiting
A new device for treating wide-necked brain aneurysms
This trial tests a special device (p48/64 MW HPC) to treat certain brain aneurysms that are wide-necked or have a shape that makes them hard to treat. It might help people with aneurysms that haven't ruptured or that have been treated before and are now coming back.
Greenville, North CarolinaAges 18 years+ - NCT05907629Recruiting
MRI study comparing blood thinners after a certain stroke
This trial looks at MRI scans to compare two types of blood-thinning medicines (one that affects blood-clotting and one that affects platelets) after a recent stroke caused by severe narrowing in certain brain arteries. It may help doctors understand which treatment works best while checking how the blood vessels and brain tissue look on MRI.
Charlotte, North CarolinaAges 18 years+
Stroke trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting stroke studies listed above.
- Duke University Medical Center · 9 studies
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist) · 3 studies
- Carolinas Rehabilitation · 2 studies
- Duke University · 2 studies
- Wake Forest University Health Sciences · 2 studies
- Atrium Health
- Atrium Health Neurosciences Institute
- Bondurant Hall
What taking part in a stroke study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Stroke trials in other states
Common questions
- Are there stroke clinical trials in North Carolina?
- Yes. We're currently tracking 31 recruiting stroke studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a stroke study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a stroke trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New stroke studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.