Clinical trials
Therapy clinical trials
Below are recruiting therapy clinical trials, each written for real people, not researchers. We’re tracking 7,177 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04731272RecruitingPhase 2
Weekly GLP-1 medicine for blood sugar issues in adults with CF
This Phase 2 trial tests a weekly GLP-1 medicine (dulaglutide) to improve blood sugar control in adults with cystic fibrosis (CF) who have trouble managing glucose. It may help people with CF-related prediabetes or diabetes by improving how their body handles sugar.
Aurora, ColoradoAges 18 years+ - NCT04696029RecruitingPhase 2
DFMO to prevent return of high-risk or relapsed medulloblastoma
This Phase 2 study tests DFMO (a maintenance medicine) to help stop medulloblastoma from coming back or worsening after prior treatment. It focuses on children and young people with specific high-risk tumor types or tumors that have returned or not responded well to treatment.
Little Rock, ArkansasAges Up to 21 years - NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients
This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.
BesançonAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT04741997RecruitingEarly Phase 1
Adjuvant melanoma treatment guided by response to targeted drugs
This early-phase study looks at whether people with melanoma can get the “right” follow-up (extra) treatment based on how well their cancer responds after starting targeted drugs before surgery. The goal is to improve outcomes while better matching treatment to each person’s tumor response.
Tampa, FloridaAges 18 years+ - NCT04703244Recruiting
Testing patient tumor samples to create research models in breast cancer
This study collects tumor-related samples from people with invasive breast cancer who are having surgery after treatment before surgery. Researchers use your samples to create lab models (called PDX and organoids) to help study breast cancer and find better future treatments.
Rochester, MinnesotaAges 18 years+ - NCT04735263RecruitingPhase 2
Testing dark vision changes as a statin response signal
This Phase 2 study looks at whether changes in night/dark adaptation can show early whether high-dose atorvastatin (a statin) is helping intermediate age-related macular degeneration (AMD). If you fit, you may help researchers find an earlier way to tell who is responding.
Boston, MassachusettsAges 50–85 - NCT04647656Recruiting
Hyperbaric oxygen for lingering post-COVID brain fog
This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve long-lasting post-COVID problems with thinking and memory. It may help if your brain symptoms have lasted at least 3 months and affect your daily life.
ẔerifinAges 18 years+ - NCT04663399Recruiting
Study immune changes after stroke treatment
This study looks at how the body’s immune system responds after an acute ischemic stroke that may be treated with a procedure called mechanical thrombectomy. It may help doctors understand what immune changes happen after treatment and improve future care.
Paris, ParisAges 18 years+ - NCT04628585Enrolling by invitation
Follow-up for people with sickle cell treated with gene therapy
This study is a long-term follow-up for people who already received gene therapy for sickle cell disease in a specific sponsor’s clinical trial. It helps researchers watch for long-term safety and outcomes over time.
Birmingham, AlabamaAges 2–53 - NCT04626674RecruitingPhase 1
Gene therapy for non-ambulatory Duchenne muscular dystrophy
This study tests a gene therapy that aims to help muscles produce a protein they are missing. It is for people with Duchenne muscular dystrophy who are no longer able to walk, and it may help slow the progression of the disease.
Little Rock, ArkansasAges 2 years+ - NCT04669717RecruitingPhase 4
Testing antibiotic dosing alongside periodontal treatment
This study tests how antibiotics should be added to standard gum (periodontal) treatment, including dosing and blood-level timing. It may help people whose gum disease is severe, by improving how antibiotics are used with routine dental care.
Geneva, Canton of GenevaAges 18–80 - NCT04664946Recruiting
Intra-arterial treatment for stroke when no reperfusion was given
This trial tests an “intra-arterial” approach (a treatment delivered through an artery to the brain) for people with ischemic stroke who were not given clot-busting therapy or a clot-removal procedure. It aims to improve neurological recovery when there wasn’t reperfusion therapy, including in cases where symptoms worsen soon after stroke.
ShenyangAges 18 years+ - NCT04683679RecruitingPhase 2
Radiation plus pembrolizumab and olaparib for certain breast cancers
This study tests whether adding the drugs pembrolizumab and olaparib (or similar “radiosensitizers”) to radiation can improve outcomes for women with advanced breast cancer that is triple-negative or ER-positive/Her2-negative. It’s designed for cancers that have spread or come back and where radiation is being considered to control disease.
Basking Ridge, New JerseyAges 18 years+ - NCT04664933Recruiting
Study to protect the brain during clot-removal stroke treatment
This trial tests a brain-protective approach given through an artery during treatment for an acute ischemic stroke when clot removal (endovascular therapy) is planned. It may help reduce brain injury related to the stroke and procedure.
ShenyangAges 18 years+ - NCT04632628Recruiting
Online sleep coaching for insomnia in dementia caregivers
This trial tests an online form of cognitive behavioral therapy (a structured skills-based program) to improve insomnia for people caring for someone with dementia. It may help reduce trouble falling asleep, staying asleep, or waking too early.
Columbia, MissouriAges 18 years+ - NCT04676828Recruiting
SPECT-guided radiation to avoid healthy lung in lung cancer
This study tests a special imaging-guided radiation plan that aims to treat lung cancer while reducing radiation to healthy lung tissue. It may help lower lung side effects while keeping the cancer treatment focused on tumor areas.
Sydney, New South WalesAges 18 years+ - NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04622423Recruiting
Advanced therapies for colon or pancreas liver metastases
This study tests advanced treatments for cancer that has spread to the liver, either from colon cancer or pancreatic cancer. It may help by targeting liver tumors using treatment plans and, for some participants, liver tissue samples.
Milan, MilanAges 18 years+ - NCT04626050Recruiting
PTSD and stress support study for healthcare workers
This study looks at psychological distress, including post-traumatic stress disorder (PTSD), in healthcare workers after work-related trauma. You may be eligible if you are an adult healthcare worker with PTSD (and otherwise stable) who can complete regular study check-ins.
New York, New YorkAges 18 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT04646187Enrolling by invitationPhase 4
Lowering biologic doses for Crohn’s and ulcerative colitis
This trial tests whether people with Crohn’s disease or ulcerative colitis who are currently well-controlled can safely use less-frequent anti-TNF medicine. It may help reduce treatment intensity while keeping inflammation under control.
GhentAges 12–25 - NCT04652908RecruitingPhase 1/Phase 2
Cell therapy given during pregnancy to repair spina bifida
This trial studies a cell-based treatment given during fetal surgery to help repair myelomeningocele (spina bifida) before birth. It aims to improve outcomes for the baby by supporting “in utero” repair, but you must meet strict pregnancy and health criteria to be considered.
Sacramento, CaliforniaAges 4 months–6 months - NCT04667494RecruitingPhase 4
Ultrasound treatment for heart amyloidosis
This trial studies whether ultrasound therapy can help people with amyloidosis that affects the heart. It’s aimed at improving heart-related outcomes in AL or transthyretin (ATTR) cardiac amyloidosis.
Boston, MassachusettsAges 18–90
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Common questions
- Are there clinical trials for therapy?
- Yes. Clin2 currently lists 7,177 recruiting therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.