Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06864130RecruitingPhase 4
Stopping Alendronate in osteoporosis after no fractures
This study wants to see if it is safe for postmenopausal women with osteoporosis to stop taking Alendronate after a long period of treatment without any new fractures. If you have been on Alendronate for a while and have stayed fracture-free, you may be able to take a break from the medicine.
AalborgAges Any age - NCT06864351Recruiting
Study of a new thyroid dosing method for children
This study tests a new way to adjust thyroid medication doses for children with either congenital hypothyroidism or Graves' disease. It aims to help find the right dose more easily and improve treatment outcomes.
ParisAges Up to 18 years - NCT06864897Recruiting
10-year follow-up of the Delta-TT trial
This study checks on people who took part in the original Delta-TT trial to see how they are doing after 10 years. It helps researchers understand the long-term effects of the treatment.
Amsterdam, North HollandAges Any age - NCT06865105RecruitingPhase 2
Targeted treatments for active psoriatic arthritis
This study tests targeted medications for people with active psoriatic arthritis (PsA) who have already tried 1 or 2 other advanced treatments without success or couldn't tolerate them. The goal is to see if these newer options can better control joint pain and skin symptoms.
Huntington Beach, CaliforniaAges 18 years+ - NCT06866054Recruiting
A block for shoulder surgery pain relief
This trial tests a nerve block to reduce pain after arthroscopic shoulder surgery. It might help you have less pain and recovery time after the procedure.
Istanbul, BagcilarAges 18–75 - NCT06866444Recruiting
Duloxetine and Fibromyalgia: How Your Body Processes the Drug
This study looks at how well duloxetine (Cymbalta) works in people with fibromyalgia. It may help doctors understand if people respond differently based on how their body breaks down the drug.
Salt Lake City, UtahAges 18 years+ - NCT06867003Recruiting
Exercise with or without bracing for office workers with kyphosis
This trial compares two treatment approaches for office workers with postural kyphosis (a rounded upper back that can cause pain). One group gets exercises alone, and the other gets exercises plus a posture brace. The goal is to find which works better for reducing pain and improving posture.
Malakand, KPKAges 30–45 - NCT06867952Recruiting
Vitamin K2 for bone loss with a specific gene change
This study tests whether taking vitamin K2 can help people with low bone density (osteopenia or osteoporosis) who have a specific change in the VDR gene. If you have this gene change, vitamin K2 may work better for you than standard supplements.
NovosibirskAges 40–75 - NCT06869343Recruiting
Early vs. Late Rehab After Shoulder Replacement for Fracture
This study compares starting shoulder rehab early (2 weeks after surgery) versus at the standard time after a reverse total shoulder replacement for a broken shoulder. It aims to see which approach helps you recover better.
Charlottesville, VirginiaAges 50–85 - NCT06869551RecruitingPhase 3
Testing a New Drug for Juvenile Psoriatic Arthritis
This study tests an investigational drug called Deucravacitinib to see if it can safely and effectively treat Juvenile Psoriatic Arthritis in children. You may be able to join if standard treatments haven't helped enough.
Lancaster, CaliforniaAges 5–17 - NCT06870045Recruiting
Walking ability test in children with JIA
This study looks at how well children with JIA (arthritis in one knee) can walk and balance, using a simple test called the Dynamic Gait Index. It aims to find a better way to measure walking problems in kids with JIA.
Istanbul, TurkeyAges 8–16 - NCT06870500Recruiting
Psoriasis gene study for Egyptian patients
This study looks at a specific gene (Card14) in Egyptian patients with psoriasis or psoriatic arthritis. It may help understand why some people get these conditions and how they could be treated better.
QinaAges 18–50 - NCT06871384Recruiting
Red wine diet for brain and body health in early elderly
This study tests whether a special diet including red wine can help improve thinking and movement in people aged 60–74. If you join, you would drink red wine as part of the diet and have your memory and physical abilities checked over time.
Logroño, SpainAges 60–74 - NCT06872567Recruiting
Knee artery block vs. steroid injection for arthritis pain
This study compares two treatments for knee arthritis pain: a procedure that blocks blood flow to the painful area (genicular artery embolization) versus a steroid injection into the knee joint. The goal is to see which one provides better pain relief.
Charlottesville, VirginiaAges 40 years+ - NCT06872918Recruiting
Study of a back manipulation for lumbar disc herniation
This study tests a specific type of back manipulation (Lever Positioning Manipulation) to understand how it affects the discs in the lower spine. It may help people with a herniated disc at L4-L5 find a non-surgical treatment option.
Hangzhou, ZhejiangAges 20–60 - NCT06873100RecruitingPhase 1/Phase 2
Upadacitinib for relapsing polychondritis
This trial tests whether upadacitinib, an oral medication, is safe and effective for people with relapsing polychondritis that hasn't improved enough with standard treatments. It aims to reduce inflammation and control symptoms.
Beijing, Beijing MunicipalityAges 18–70 - NCT06873113Recruiting
Blood flow therapy for shoulder pain
This study tests a new type of physical therapy that uses a blood pressure cuff to gently limit blood flow to the arm during exercise. It may help people with shoulder pain from subacromial impingement (a common cause of shoulder pain) regain function.
Gainesville, FloridaAges 18–50 - NCT06874517Recruiting
Foot shape and big toe angle study
This study looks at whether the length of your second toe relates to a condition called hallux valgus (a bunion, where the big toe angles toward the other toes). Researchers will measure foot X-rays to compare two common foot shapes: Greek foot (longer second toe) and Egyptian foot (shorter second toe).
Istanbul, BeylikdüzüAges 60–80 - NCT06874608Recruiting
Does an exclusion diet help juvenile arthritis?
This study tests if removing certain foods can improve arthritis symptoms in children aged 6 to 17. It may be an option if current medicines are not working well or if you want to explore dietary changes.
FlorenceAges 6–18 - NCT06874803Recruiting
Acupuncture and moxibustion for early Parkinson's motor symptoms
This trial tests whether acupuncture and moxibustion can help improve movement symptoms in people with early to moderate Parkinson's disease. It is designed to see if adding these treatments to your regular care offers extra benefits.
Beijing, Beijing MunicipalityAges 30–80 - NCT06874868Recruiting
Saliva stress test for jaw pain disorder
This study measures cortisol levels in your saliva to see if it can help diagnose temporomandibular disorder (jaw pain). It aims to find a simple way to better understand this condition.
Coimbra, Coimbra DistrictAges 18 years+ - NCT06875102Recruiting
Treating fatigue in Sjögren's syndrome with auricular stimulation
This trial tests three non-medication strategies for fatigue in Sjögren's syndrome, including a type of ear stimulation. It aims to find a better way to help people who have had fatigue for at least 6 months with no clear cause.
Saint-EtienneAges 18 years+ - NCT06875804Recruiting
Compressive release for knee cap tracking in knee pain
This trial tests a hands-on therapy called compressive myofascial release for the muscle on the outside of your thigh. It aims to see if it helps with kneecap tracking problems that cause pain during daily activities.
Lahore, Punjab ProvinceAges 20–40 - NCT06875817Recruiting
Feldenkrais exercises for knee osteoarthritis pain
This study tests if gentle, slow Feldenkrais movement exercises can reduce knee pain and improve mobility in people with moderate knee osteoarthritis. It is designed for those who are still able to walk and get up from the floor, but are experiencing significant pain.
Lahore, Punjab ProvinceAges 40–60
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.