Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06876896Recruiting
Pressure inside belly during pulse field ablation for A-fib
This study looks at how pulse field ablation (a heart procedure for irregular heartbeats) affects pressure inside the belly. If you have atrial fibrillation or atrial flutter and are planning to have this procedure, your participation may help doctors understand how to make it safer.
Winston-Salem, North CarolinaAges 18 years+ - NCT06877078Recruiting
Podcast for constipation before surgery
This study tests if listening to a podcast about preventing constipation before surgery can help people who are having back, shoulder, knee, or hip surgery. If you are scheduled for one of these surgeries, you may be able to take part.
SilkeborgAges 18 years+ - NCT06877793Recruiting
Using dye imaging to diagnose severe flesh-eating infections
This trial tests a new way to quickly diagnose necrotizing soft tissue infections (NSTIs, also called flesh-eating infections) using a safe dye and a camera. If you are being checked for a possible NSTI, this could help doctors decide faster whether you have it and need treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT06878417Recruiting
Cannabinoids for osteoarthritis knee or hip pain
This study tests if cannabinoid medications can reduce pain interference in daily life for people with hip or knee osteoarthritis. It may be a new option for moderate to severe pain.
Toronto, OntarioAges 40–80 - NCT06878950Recruiting
Early feeding for babies with gastroschisis
This study tests whether starting feedings earlier than usual helps babies born with gastroschisis recover better. It aims to find a safer and more effective feeding plan for these newborns.
Los Angeles, CaliforniaAges birth–1 year - NCT06879743Recruiting
Gentle neck release for fibromyalgia pain
This study tests whether a gentle hands-on technique called suboccipital release can help ease fibromyalgia pain. It’s for women aged 20–45 with a stable fibromyalgia diagnosis who do not have certain other conditions or use strong pain medications.
CairoAges 20–45 - NCT06880653Recruiting
Exercise dose study for arthritis pain
This study looks at how different amounts of exercise affect arthritis symptoms. If you have arthritis or a related condition, you may be asked to try a specific weekly exercise goal to see if it helps your pain and mobility.
Columbia, South CarolinaAges 18 years+ - NCT06881498Recruiting
Blood thinning technique for bone tumor surgery
This trial tests a technique called 'acute normovolemic hemodilution' during bone tumor surgery. It involves temporarily thinning your blood by removing some red blood cells and replacing them with fluid, which may reduce the need for blood transfusions.
Hangzhou, ZhejiangAges 18–75 - NCT06883396Recruiting
Looking at why MPFL knee surgery fails
This study looks at why some people's kneecaps keep dislocating after a specific type of surgery (MPFL reconstruction). It aims to find risk factors that might cause the surgery to not work as well.
Redwood City, CaliforniaAges 10–35 - NCT06883669Recruiting
AI for wrist and hand joint ultrasound
This study is testing if an artificial intelligence program can help doctors take clearer images of the wrist and hand using ultrasound. It is for healthy volunteers to help build the AI system, and for experienced sonographers to test how well it works.
Chengdu, SichuanAges 18–100 - NCT06886906Recruiting
Movement and Pain in Older Adults
This study explores how movement and physical activity relate to pain in older adults with muscle or joint pain. It could help you understand your pain patterns and find better ways to manage them.
Indianapolis, IndianaAges 55–85 - NCT06887127RecruitingPhase 3
Long-term safety study of TLL-018 for rheumatoid arthritis patients
This study offers continued access to TLL-018 for people with rheumatoid arthritis who completed the earlier study (TLL-018-301). It checks long-term safety and helps researchers understand if the medicine remains effective over time.
Beijing, Beijing MunicipalityAges 18–75 - NCT06888544Recruiting
High-intensity interval training for bone health in older women
This trial tests whether high-intensity interval training (short bursts of intense exercise) can improve bone health in women aged 60 to 74 with osteopenia (low bone density, but not osteoporosis). Participation involves supervised exercise sessions and bone density measurements.
China, Hong KongAges 60–74 - NCT06888791Recruiting
Hydro dissection for frozen shoulder: ultrasound vs X-ray guidance
This trial compares two ways to guide a fluid injection for frozen shoulder—one using ultrasound and one using X-ray. The goal is to see which technique works better to reduce pain and improve movement.
AnkaraAges 18–80 - NCT06888960RecruitingEarly Phase 1
Testing CC312 for people with autoimmune diseases
This early-phase study tests a new drug called CC312 in patients with certain autoimmune diseases like lupus, myositis, scleroderma, rheumatoid arthritis, immune thrombocytopenia, or autoimmune hemolytic anemia. The goal is to see if it's safe and how the body handles it.
Tianjin, ChinaAges 18 years+ - NCT06889415Recruiting
Rheumatoid Arthritis and Bone & Muscle Loss: A Study
This study looks at how rheumatoid arthritis relates to bone thinning and muscle loss in people over 50. It aims to find what factors are linked to these conditions.
Konya, SelçukluAges 50 years+ - NCT06890000Recruiting
Scapular exercises for shoulder pain relief
This trial tests if special exercises for the shoulder blade (scapula) can reduce shoulder pain better than standard exercises. It is for people with shoulder pain that has lasted at least one month and who have a shoulder blade that moves incorrectly.
AnkaraAges 18 years+ - NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85 - NCT06893614Recruiting
Facial mesh study for jaw surgery patients
This trial uses computer scans to create facial shape meshes for patients who had jaw surgery to correct an underbite. It aims to improve planning for future surgeries.
Cairo, AbbassiaAges 18–50 - NCT06896032Recruiting
Walking backward vs forward on an underwater treadmill for knee osteoarthritis
This study compares walking backward versus walking forward on an underwater treadmill to see which helps reduce pain and improve function in people with knee osteoarthritis. It may be a good fit if you have mild to moderate knee OA in one knee and are between 40 and 60 years old.
Cairo, Cairo GovernorateAges 40–60 - NCT06897293Recruiting
Tape Implant vs Standard Repair for Ankle Instability
This trial tests whether adding a special tape to a standard ankle ligament repair helps people with chronic ankle instability more than the standard repair alone. If you have loose joints and a history of ankle giving way, this study may be an option.
Beijing, Beijing MunicipalityAges 15–55 - NCT06897943Recruiting
Gonococcal arthritis study (2014-2024)
This study looks at people who had a joint infection caused by gonorrhea bacteria between 2014 and 2024. Researchers want to learn more about how common this condition is and how it affects people.
Rennes, Brittany RegionAges Any age - NCT06898554Recruiting
Understanding Ankle Control in Athletes with Unstable Ankles
This trial studies how your brain and spinal cord control your ankle if you have chronic ankle instability (a long-term wobbly ankle). It is for athletes between 18 and 25 who play team sports and have had repeated ankle sprains.
IstanbulAges 18–25 - NCT06899932Recruiting
Genutech knee replacement survival study
This study tracks how long Genutech knee replacements last in people with knee arthritis. It is for adults whose arthritis did not improve with non-surgical treatments like physical therapy or medication.
Barcelona, BarcelonaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.