Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06845657Recruiting
Hip strengthening exercises for knee arthritis
This study tests if strengthening the hip muscles can reduce knee pain and improve function in people with knee osteoarthritis. It may help you if you have had knee pain for at least 3 months and are between 40 and 60 years old.
Islamabad, Punjab ProvinceAges 40–60 - NCT06845735Recruiting
Comparing two types of stitches for hip surgery closure
This trial compares two types of stitches (absorbable vs. non-absorbable) used to close the hip capsule during hip arthroscopy, to see if one leads to better recovery. If you need hip arthroscopy for a hip problem, you may be able to join.
Columbia, MissouriAges 18 years+ - NCT06846190Recruiting
Modified arm therapy versus virtual reality for children with cerebral palsy
This study compares two types of therapy to help children with cerebral palsy use their weaker arm better. One therapy involves gently restraining the strong arm to encourage use of the weaker arm, and the other uses virtual reality games to practice arm movements.
Lahore, Punjab ProvinceAges 6–12 - NCT06846697Recruiting
Yoga and Pilates for Posture Correction
This trial compares two gentle exercise methods—Hatha yoga and Reformer Pilates—to see which helps improve a rounded upper back (hyperkyphosis) caused by poor posture. It's a non-surgical option that may strengthen your back and improve your posture.
Konak, İ̇zmi̇rAges 18–65 - NCT06847282Recruiting
Motor skills study for children with FSHD
This study looks at how children with FSHD move and function over time. It uses walking tests and optional MRI scans to understand muscle changes. Your child's participation could help researchers learn more about FSHD progression in kids.
Palo Alto, CaliforniaAges 5–17 - NCT06848374RecruitingPhase 3
Dose study for frozen shoulder treatment
This study tests whether different doses of a steroid injection can help treat frozen shoulder (adhesive capsulitis). If you have frozen shoulder and haven't had a recent injection or surgery on that shoulder, you may be able to join.
Toronto, OntarioAges 18 years+ - NCT06850194Recruiting
Comparing two jaw surgeries for severe underbite
This trial compares two surgical techniques to fix a severe underbite caused by a small lower jaw. One method uses a special cut in the jawbone and a piece of hip bone to lengthen it, while the other uses a different jawbone cut to move the jaw forward. It will help find which approach works better for people with this condition.
Beni-seuf, EgyptAges 18 years+ - NCT06850818Recruiting
Hip and knee implant registry study
This study is creating a registry of patients who have hip or knee replacement surgery or revision surgery at a specific hospital. The goal is to track outcomes and improve care for future patients.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06851091Recruiting
Fibromyalgia study on pain sensitivity and balance
This study looks at how fibromyalgia affects your sensitivity to pain and your sense of balance. It may help find better ways to treat these symptoms.
Istanbul, ÜsküdarAges 18–65 - NCT06851676Recruiting
Testing mineral water's effects on bone and muscle health
This trial tests if drinking Fonte Fausta® mineral water can help improve bone and muscle health in people with weak bones (osteopenia or osteoporosis). Researchers want to see if this water has special benefits beyond regular water.
Naples, ItalyAges 65 years+ - NCT06853132Recruiting
Baduanjin with resistance training for back pain or osteoporosis
This study tests a gentle exercise program called Baduanjin combined with resistance training for people with back problems or osteoporosis who are about to have surgery. It aims to see if this type of exercise helps before and after the procedure.
Changsha, HunanAges 45 years+ - NCT06854809Recruiting
Cognitive therapy vs. exercises for chronic shoulder pain
This study compares two non-surgical treatments for long-lasting shoulder pain: a new approach called cognitive functional therapy that combines movement with education, versus standard exercises. If you have chronic shoulder pain and are looking for a drug-free option, this trial may help you find which treatment works better.
São Carlos, São PauloAges 18–65 - NCT06856330Recruiting
Trial on a new surgery for speech in children with cleft lip and palate
This trial tests a surgical technique (Furlow palatoplasty with a cheek muscle flap) to see if it improves speech development in young children who had a complete cleft lip and palate repaired previously. It may help children between 3 and 5 years old with non-syndromic conditions.
Al FayyumAges 3–5 - NCT06856356Recruiting
Robot-assisted knee replacement surgery study
This study tests if robot-assisted total knee replacement surgery is safe and effective. It may help people who need knee replacement surgery by using advanced technology for more precise implant placement.
Hefei, AnhuiAges 18–80 - NCT06856824Recruiting
Ultrasound-Guided Injection vs Surgical Repair for Biceps Pain
This study compares two ways to treat biceps tendon pain: a ultrasound-guided injection versus a minor surgical repair. The goal is to see which method gives better function and less pain.
BogotáAges 18–99 - NCT06857123Recruiting
Rest breaks during exercise for knee osteoarthritis
This study is testing whether adding short rest breaks during exercise can help people with knee osteoarthritis feel better and stick with a program. It may be a good option if you have mild to moderate knee pain and are not very active right now.
Pittsburgh, PennsylvaniaAges 45–79 - NCT06857227RecruitingPhase 1
Study of GNC-038 for active rheumatoid arthritis
This trial tests a new experimental antibody called GNC-038 for people with moderate to severe rheumatoid arthritis (RA) that hasn't responded well enough to standard treatments. It aims to see if targeting specific immune cells can reduce inflammation and improve symptoms.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06857240RecruitingPhase 2
Ruxolitinib cream for stubborn skin in dermatomyositis
This trial tests a cream called ruxolitinib for people with dermatomyositis whose skin symptoms haven't improved with standard treatments. It aims to see if this cream can reduce rash and activity when added to your current medications.
Cleveland, OhioAges 18–89 - NCT06857708Recruiting
Wound dressings for necrotizing fasciitis wounds
This study tests two special wound dressings (Cytal® Wound Matrix and MicroMatrix®) to help heal wounds caused by a serious flesh-eating infection called necrotizing fasciitis. The goal is to see if these dressings improve healing and reduce the need for more surgeries.
Cleveland, OhioAges 18 years+ - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT06862843Recruiting
Family eating habits and chronic inflammation study
This study looks at how eating habits and family health history relate to chronic inflammatory conditions like Crohn's disease, ulcerative colitis, and juvenile idiopathic arthritis. It aims to understand these links by studying families with a child or adult affected by these conditions, as well as healthy families.
Florence, ItalyAges Any age - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06863701RecruitingPhase 3
Combination therapy for acute gout flare
This trial tests a combination of two medicines, etoricoxib and betamethasone, for quickly treating a painful gout flare. It is for people who have had gout before and whose current attack started within two days.
Mexico CityAges 18 years+ - NCT06864026RecruitingPhase 4
Adding tirzepatide to ixekizumab for psoriatic arthritis with weight concerns
This study tests adding tirzepatide (a once-weekly injection for weight and diabetes) to your current treatment with ixekizumab for psoriatic arthritis. It may help with both joint symptoms and weight.
Avondale, ArizonaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.