Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07351981Enrolling by invitation
Cooled radiofrequency for knee osteoarthritis pain
This study tests a new approach called cooled radiofrequency (TcPRF) to calm knee pain from osteoarthritis. It may be an option if standard treatments haven't worked and you haven't had certain other treatments recently.
AthensAges 45 years+ - NCT07345351Enrolling by invitation
Pilates vs. lifestyle advice for jaw muscle pain
This study compares two non-drug treatments for jaw muscle pain: clinical Pilates vs. lifestyle counseling. It aims to see which approach better reduces pain and improves jaw function in women.
Antakya, HatayAges 18–45 - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT07344727Recruiting
Can haskap berries help you recover after heavy squats?
This study tests whether taking haskap berries (a type of superfruit) before and after intense squat workouts can speed up your recovery and reduce soreness.
Bozeman, MontanaAges 18–35 - NCT07350681Recruiting
Jaw surgery's effect on foot pressure and posture
This study looks at how jaw surgery (orthognathic surgery) affects your foot pressure and body posture. You might join if you are already planning this surgery as part of your orthodontic treatment.
Istanbul, FatihAges 18 years+ - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT07345949Recruiting
Study of skin inflammation in dermatomyositis
This trial looks at a type of skin inflammation called panniculitis that can happen in people with dermatomyositis. The goal is to learn more about this condition so that better treatments can be developed.
StrasbourgAges 1 year+ - NCT07346079RecruitingPhase 4
Corticotropin gel for acute gout flares
This study tests two doses of a medicine called Purified Cortrophin Gel for people having a gout flare that started in the last 5 days. It might be an option if other treatments haven't worked or aren't safe for you.
Boston, MassachusettsAges 18–90 - NCT07344077Recruiting
One vs two wires for severe bunion surgery
This trial compares two ways of fixing the bone after bunion surgery (using one or two small wires). It's for people with severe bunions who haven't gotten better with non-surgical treatments.
Chon Buri, Changwat Chon BuriAges 18–60 - NCT07346989Recruiting
Brain stimulation to improve function in frail older adults
This study uses a gentle, non-invasive brain stimulation technique (called transcranial direct current stimulation, or tDCS) to see if it can improve physical function and daily activities in older adults who are showing early signs of frailty. You will be asked to do some simple exercises and cognitive tasks while receiving or not receiving the stimulation.
Valencia, ValenciaAges 65–90 - NCT07347860RecruitingEarly Phase 1
Study of A-319 for active rheumatoid arthritis
This trial tests a new drug called A-319 for people with active rheumatoid arthritis (RA) that hasn't improved enough after trying other treatments. The goal is to see if A-319 can reduce joint pain, swelling, and inflammation.
Wuhan, HubeiAges 18–70 - NCT07350395Recruiting
How steroids affect children with autoimmune conditions
This study talks to children and young people with autoimmune or inflammatory conditions (like juvenile arthritis) who have taken steroids in the past two years. It aims to understand how steroids impact their daily lives and feelings.
Bristol, North SomersetAges Up to 18 years - NCT07347873Recruiting
Testing accuracy of exams for tennis elbow
This study compares several simple physical exams and an ultrasound test to see how well they can diagnose a common elbow problem called lateral elbow tendinopathy (tennis elbow). If you have pain on the outside of your elbow, this research might help confirm what is causing it.
Istanbul, MaltepeAges 18–60 - NCT07351526Recruiting
Rehabilitation study for patients after hospital stay
This study looks at how patients do during inpatient rehab after a hospital stay. It aims to understand what helps people recover and what their recovery looks like.
Limerick, MunsterAges 18 years+ - NCT07348263Recruiting
Study on childhood eosinophilic fasciitis
This study looks at children diagnosed with eosinophilic fasciitis (a rare condition that causes skin swelling and stiffness) between 2000 and 2026. It aims to learn more about the disease and how it affects patients over time.
Birmingham, AlabamaAges Up to 18 years - NCT07343752Recruiting
Blood flow restriction therapy for teen flat feet
This study tests whether adding a special blood-flow restriction technique to physical therapy helps teenagers with stiff, spasming flat feet more than physical therapy alone. It is for teens whose flat feet didn't get better with initial treatment.
AsyutAges 10–18 - NCT07347041Recruiting
Trigger point injections for hip osteoarthritis pain
This study tests if injecting pain-relieving medication into tight muscle knots (called trigger points) can reduce hip pain from osteoarthritis. It is for people who still have pain despite trying other treatments.
Beijing, Beijing MunicipalityAges 45 years+ - NCT06237647Recruiting
Comparing injections for partial rotator cuff tears
This study compares three types of injections—steroids, PRP (platelet-rich plasma), and PRP combined with hyaluronic acid—to see which works best for partial rotator cuff tears. If you have shoulder pain from a partial tear, this trial may help find the most effective treatment for you.
Kaohsiung City, SanminAges 20–85 - NCT06747052Recruiting
How gender affects physical activity for preventing joint pain
This study looks at how being male or female affects physical activity habits and how that might help prevent long-term muscle and joint problems. It is open to adults in Lombardy, Italy, who can speak Italian.
Milan, ItalyAges 18–64 - NCT06858358Recruiting
Robot vs. standard knee replacement for severe arthritis
This trial compares a robot-assisted knee replacement technique to the standard approach for people with severe knee arthritis. It aims to see which method leads to better recovery and outcomes.
Cluj-Napoca, ClujAges Any age - NCT07339111RecruitingPhase 3
CARTISTEM vs surgery for knee cartilage damage and osteoarthritis
This trial tests if a cell-based treatment called CARTISTEM can repair knee cartilage better than surgery alone. It involves people with knee osteoarthritis and a cartilage defect, with moderate pain and limited function.
Birmingham, AlabamaAges 18–75 - NCT07338266RecruitingPhase 1
Study of AVD275 injection for knee osteoarthritis
This trial tests a new injection called AVD275 for people with knee osteoarthritis. It aims to see if the injection is safe and how it works in the body.
Wahroonga, New South WalesAges 20–75 - NCT07337642Recruiting
Comparing two types of hip replacement stems
This study compares two kinds of hip implant stems (one with a collar, one without) to see which works better for patients getting their first total hip replacement. If you are scheduled for a cement-free hip replacement due to arthritis, this trial may be a good fit.
Washington D.C., District of ColumbiaAges 18–99 - NCT07342959Recruiting
Anchor surgery for elbow fracture in children
This trial studies a surgery using anchors to fix a broken bone in the elbow (the medial epicondyle) in children under 15. It aims to see how well this technique works for displaced fractures.
StrasbourgAges 1–14
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.