Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT07135817Recruiting
Pre-surgery radiation for spinal tumors
This trial tests whether giving focused radiation before surgery can improve treatment for spinal tumors that have spread from other cancers. It may help people who need surgery for a spinal tumor and have a life expectancy of more than 6 months.
GöttingenAges 18 years+ - NCT07171996Recruiting
Radioactive seed therapy for spinal tumors
This trial tests a procedure where tiny radioactive seeds are placed into spinal tumors to relieve pain and control growth. It is for people with cancer that has spread to the bone and who are able to undergo the procedure safely.
Jinan, ShandongAges 18–55 - NCT07163117Recruiting
Back exercises for female university students with back pain
This study tests two different types of back exercises to see which works better for reducing mechanical low back pain (pain not caused by injury or disease) in female university students. It may help you find a good exercise routine if you have had this type of back pain for a while.
CairoAges 18–24 - NCT07092917Recruiting
Spinal fusion surgery for teen scoliosis
This trial studies the outcomes and complications of posterior spinal fusion surgery in teens with adolescent idiopathic scoliosis. It aims to help those with moderate to severe curves that are getting worse quickly or causing functional problems.
Asyut, EgyptAges 8–21 - NCT07125040Recruiting
Understanding LAMA2 muscle disease over time
This study follows people with LAMA2-related muscular dystrophy (a genetic muscle-weakening condition) to learn how it changes over time and find better ways to measure it. By participating, you help researchers identify new disease markers that could improve future treatments.
MilanAges Any age - NCT07145957Recruiting
Pre-surgery exercise program for better shoulder rotation after replacement
This study tests if a special exercise program before shoulder replacement surgery improves how well you can rotate your arm inward after the operation. Participants do exercises for 6 weeks before surgery and are followed for 2 years.
Gainesville, FloridaAges 40–80 - NCT07147959RecruitingPhase 2
PET imaging study for rheumatoid arthritis
This trial uses a special PET scan to see how an experimental drug, CIT-013, targets inflammation in the body. It's for people with rheumatoid arthritis to better understand how the drug works.
NijmegenAges 60–85 - NCT07179497Recruiting
Study of Neobone in dental bone surgery
This study looks at how safe and effective Neobone is for repairing bone in dental surgery. If you need a bone graft for your jaw or teeth, this could be relevant.
LisbonAges 18 years+ - NCT07157319Recruiting
Zadek osteotomy for Haglund's syndrome
This trial tests a surgery called Zadek osteotomy for people with Haglund's syndrome (a painful heel condition). It may help those who haven't gotten better after at least six months of non-surgical treatments.
SohagAges 18–60 - NCT07045259Recruiting
Exergaming vs. exercise for memory and movement in seniors
This study compares fun video games that get you moving (exergaming) with standard muscle-strengthening exercises. It aims to see which one better helps older adults who have both slower walking speed and memory concerns.
BalıkesirAges 65 years+ - NCT07696923Recruiting
Treating frozen shoulder with microembolization or steroid injection
This trial compares two treatments for frozen shoulder: a new procedure that blocks tiny blood vessels (TAME) and a steroid injection. You must have had shoulder pain for at least a month and be willing to do physical therapy.
TaipeiAges 18–80 - NCT06674109RecruitingPhase 4
Testing a diabetes drug for gout prevention
This study tests if a type 2 diabetes medication (SGLT2 inhibitor) can help people with frequent gout flares. It aims to lower uric acid levels and reduce flare-ups.
Boston, MassachusettsAges 18–80 - NCT05720065RecruitingPhase 2
Testing botulinum toxin A for jaw muscle pain
This trial studies whether botulinum toxin A (a type of muscle-relaxing medicine) can reduce jaw muscle pain and help explain why it happens. It focuses on people with specific jaw muscle pain patterns and tests outcomes after injection/biopsy.
Huddinge, Stockholm CountyAges 20–45 - NCT06296017Recruiting
Comparing nonsurgical treatments for trigger finger
This study compares nonsurgical treatments (like exercises, splints, or injections) for trigger finger. It aims to find which conservative approach works best for mild cases without surgery.
AnkaraAges 18–65 - NCT05596539Recruiting
Study of adults with low alkaline phosphatase
This is a long-term observational study (not a drug trial) that follows adults with signs of hypophosphatasia, a condition linked to very low alkaline phosphatase levels and sometimes a gene change. It aims to better understand the condition over time and how symptoms look and progress.
Bordeaux, FranceAges 18 years+ - NCT06848023Enrolling by invitation
Shoulder replacement vs tendon repair in older adults
This study compares how well two different shoulder surgeries—reverse total shoulder replacement and rotator cuff repair—work for people 60 and older, at least one year after the operation. If you meet the age and surgery requirements, your results could help doctors decide which procedure is better for older adults.
Germantown, TennesseeAges 60–95 - NCT06407427Recruiting
Mobile app for recovery after hip, knee, or spine surgery
This study tests whether a mobile app can help with physical therapy after common bone or joint surgeries. You may qualify if you recently had a hip fracture, hip or knee replacement, or spine surgery without paralysis. The app guides your exercises at home.
New Haven, ConnecticutAges 18 years+ - NCT06409013Recruiting
Dye-guided surgery for sarcoma removal
This study tests whether using a special dye during surgery helps doctors see and remove sarcoma tumors more completely. It may help improve the chances that no cancer is left behind.
Rochester, MinnesotaAges 18 years+ - NCT07745426RecruitingPhase 2
Comparing add-on treatments for rheumatoid arthritis
This trial compares two additional medicines (diosmin or rebamipide) taken with standard arthritis treatment to see if they help reduce joint pain and swelling better than standard treatment alone.
TantaAges 18–70 - NCT07667556Recruiting
Frozen shoulder treatment: gentle movement, pain education, and core exercises
This study tests whether a combination of gentle joint movement techniques, pain education, and core-strengthening exercises can help people with frozen shoulder move better and feel less pain. It may be a good fit if you have been diagnosed with frozen shoulder and are looking for a drug-free treatment option.
IstanbulAges 18–65 - NCT07228936Recruiting
Pectoralis minor tightness and rotator cuff tears
This trial looks at whether tightness in a small chest muscle (pectoralis minor) is linked to rotator cuff tears. If you have a partial rotator cuff tear or a healthy shoulder, you might be able to join to help answer this question.
Ankara, CankayaAges 18–55 - NCT07521280Recruiting
Custom rehab for young athletes with knee or heel pain
This trial tests personalized physical therapy exercises to help young athletes recover from Osgood-Schlatter knee pain or Sever heel pain. The study tracks how well the rehabilitation program reduces pain and helps you get back to sports.
Gdansk, Debinki 7Ages 10–17 - NCT07740967Recruiting
Collagen and omega supplements for middle-aged women
This study tests whether daily collagen and omega-3 supplements can improve health in healthy middle-aged women. You would take the supplements for a period and have your health measured.
LoughboroughAges 35–65 - NCT06989138Recruiting
Brace and exercise for spondylolisthesis
This trial tests if wearing a back brace combined with exercise helps people with a specific type of low back problem called spondylolisthesis (where a spine bone slips forward). It may reduce pain and improve function.
Istanbul, IstanbulAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.