Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT06707454Recruiting
Recovery after open heart surgery in older adults
This study looks at how older adults recover after open heart surgery, focusing on brain and nerve health. It may help researchers understand the effects of surgery on thinking and memory.
CairoAges 60 years+ - NCT06243016Recruiting
Breaking sitting with high-intensity exercise for brain health
This study tests whether breaking up long periods of sitting with short bursts of high-intensity exercise can improve brain health. It is for people who are sedentary and not very active but otherwise generally healthy.
Urbana, IllinoisAges 40–75 - NCT07220265Recruiting
PKU carriers: How high phenylalanine affects the brain
This study looks at how carrying one copy of the PKU gene might affect thinking and brain health in adults. It will help researchers understand if mild changes in a substance called phenylalanine can impact memory, focus, and brain scans.
Columbia, MissouriAges 18–60 - NCT07687979Recruiting
Mobile app for walking training in Parkinson's disease
This trial tests whether a mobile phone app can help improve walking in people with Parkinson's disease. If you have mild to moderate Parkinson's and can use a smartphone, you may be able to join.
Izmir, İzmirAges 60–80 - NCT05872347RecruitingPhase 2
Brain metastasis breast cancer trial with hormone therapy plus SPH4336
This trial tests whether SPH4336, added to standard hormone (endocrine) therapy, can improve outcomes for people with breast cancer that has spread to the brain. It also looks closely at safety and side effects.
Hefei, AnhuiAges 18–75 - NCT07215104Recruiting
Spinal cord stimulation for chronic low back pain
This trial tests a special type of spinal cord stimulation (called BurstDR) in people with chronic low back pain. If you already have a spinal cord stimulator and it helps your pain, researchers want to see if adding muscle stimulation can provide even more relief.
Charleston, West VirginiaAges 18 years+ - NCT07095465Enrolling by invitationPhase 3
Long-term study of ACP-204 for psychosis in Lewy body dementia
This study tests a medication called ACP-204 for psychosis (hallucinations or delusions) in people with Lewy body dementia. It is a long-term extension open to patients who completed a previous ACP-204 study, to see if the drug continues to be helpful and safe.
Irvine, CaliforniaAges 55–84 - NCT06520020Recruiting
Spinal cord stimulation for spinal cord injury
This study tests whether a gentle electrical stimulation applied to the skin over the spine can be safely used for people with spinal cord injury. If you have had a surgery to stabilize your spine, this stimulation could help with recovery.
Lexington, KentuckyAges 18–80 - NCT05265546RecruitingPhase 1
Psilocybin study of changes in how you see
This Phase 1 study tests whether psilocybin affects visual perception and how visual information is represented in the brain. It also studies safety and what brain/vision changes happen after the dose.
Berkeley, CaliforniaAges 21 years+ - NCT06379971RecruitingPhase 1
Choline for cannabis use in pregnancy
This trial tests whether taking choline (a vitamin-like nutrient) during pregnancy can help protect the baby's brain development in women who use cannabis. It aims to understand if choline supplementation can reduce potential risks linked to cannabis use.
Aurora, ColoradoAges 18–45 - NCT05980949RecruitingPhase 3
Long-term safety study of KarXT for Alzheimer's psychosis
This trial tests the long-term safety of an investigational drug called KarXT for people with psychosis caused by Alzheimer's disease. It is for those who have already completed a previous KarXT study and want to continue treatment.
Homewood, AlabamaAges 55–90 - NCT07718295Recruiting
High-flow oxygen vs face mask for brain oxygen during sedation
This study compares two ways of giving oxygen (high-flow nasal oxygen vs a face mask) to see which one keeps brain oxygen levels more stable during procedures done with sedation. If you are having a planned procedure with sedation in a non-operating room setting, this trial might help improve your safety.
Elâzığ, ElâzığAges 18 years+ - NCT05970406Enrolling by invitation
High-intensity swallow therapy after ischemic stroke
This trial tests a more intensive swallow-therapy program for people with difficulty swallowing soon after an ischemic stroke. It may help improve safety and function when eating and drinking.
Baltimore, MarylandAges 18–99 - NCT06922500Recruiting
Brain-Wave Monitoring During Brain Tumor Surgery
This study tests a special brain-wave monitor (called processed EEG) during surgery to remove a brain tumor. The monitor helps the anesthesiologist keep you at the right level of sleep, which may improve safety and recovery.
LundAges 18 years+ - NCT05970549Recruiting
Catheter system to drain brain fluid in bleeding
This trial tests a special catheter system used to drain cerebrospinal fluid (the fluid around the brain and spinal cord) in adults with bleeding into the brain’s fluid spaces. It may help because doctors can use the catheter soon after the bleeding to manage fluid and pressure.
New York, New YorkAges 18 years+ - NCT07191275Recruiting
TMS study on emotional image perception
This study uses transcranial magnetic stimulation (TMS), a non-invasive brain stimulation method, to see how it affects the way you perceive emotional images. It may help researchers understand brain processes related to emotions.
Basel, Canton of Basel-CityAges 18–30 - NCT06258538Recruiting
Robot-assisted arm therapy and exercise after stroke
This study tests if combining arm exercises with two types of robot-assisted therapy helps people who have had a stroke improve their arm movement, daily activities, and quality of life. It is designed for individuals with moderate arm weakness.
Taoyuan, TaoyuanAges 20–75 - NCT07638046RecruitingPhase 2
Mindful Walking and Brain Function in Older Adults
This study looks at how mindful walking—combining walking with focused attention—affects thinking and memory in older adults at risk for dementia. Researchers will track your brain activity and daily movement to see if this approach helps protect brain health.
Columbia, South CarolinaAges 60 years+ - NCT07063732Recruiting
Ketone drink, high altitude, and brain blood flow during exercise
This trial tests whether a ketone monoester supplement affects brain blood flow and exercise performance at high altitude. It may help us understand how to support brain function during altitude exposure.
Bishop, CaliforniaAges 18–35 - NCT05449106Recruiting
Medical-only care study for unruptured brain AVMs
This study looks at outcomes for people with an unruptured brain arteriovenous malformation (AVM) using medical care only, without procedures. It may help doctors understand which medical approach and monitoring works best for different AVM locations seen on CT scans.
Beijing, Beijing MunicipalityAges 3–80 - NCT06692309Recruiting
Can brain wave patterns predict thinking problems after heart surgery?
This study uses a brain wave recording device (EEG) during heart surgery to see if it can predict short-term confusion or memory problems after the operation. It may help doctors find and treat thinking issues earlier.
Beijing, Beijing MunicipalityAges 60 years+ - NCT07588113Recruiting
Brain Stimulation Study on Motor Control and Learning
This study uses a non-invasive brain stimulation technique called rTMS (repetitive transcranial magnetic stimulation) to understand how the brain controls movement and learning. Researchers will measure changes in your brain's electrical activity while you play a video game, which may help them understand how the brain learns new motor skills.
Indianapolis, IndianaAges 18–45 - NCT06018363RecruitingPhase 1/Phase 2
Cell therapy for recurrent high-grade glioma
This trial tests a new cell therapy (QH104) for people with an aggressive brain tumor called high-grade glioma that has come back or worsened after standard treatment. The therapy targets a specific protein (B7-H3) on tumor cells to try to fight the cancer.
Suzhou, JiangsuAges 18–70 - NCT07106385Recruiting
rTMS for better sleep in healthy adults
This study tests if a non-invasive brain stimulation method called rTMS can help improve sleep in adults who are generally healthy but have sleep complaints. If you are 18–65 and often have trouble sleeping, this might be a way to try a new approach without medication.
Hong Kong, Pok Fu LamAges 18–65
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.