Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT05424406Recruiting
Studying sleep timing changes in people with night-shift disorder
This study looks at how changes in your body clock (circadian timing) relate to “shift work disorder” in people who work night shifts. It may help researchers understand what drives symptoms and how to better target treatment.
Novi, MichiganAges 18 years+ - NCT07500103Recruiting
Brain stimulation to help thinking and social skills in cerebellar disease
This trial tests a noninvasive brain stimulation method (tACS) to see if it can improve thinking, memory, and social abilities in people with cerebellar conditions. It may help if you have a cerebellar malformation or degenerative atrophy and are between 12 and 32 years old.
PaviaAges 12 years+ - NCT07497100Recruiting
Arm function and daily life in hemiplegic cerebral palsy
This study looks at how arm and hand function affects daily activities in children with hemiplegic cerebral palsy. It aims to help understand how to improve participation in everyday tasks.
CairoAges 5–8 - NCT07602387Recruiting
Capsaicin cream for chemo-related nerve pain in legs
This study tests whether an 8% capsaicin cream (a chili-pepper derived treatment) can help reduce nerve pain and numbness in the legs caused by cancer chemotherapy drugs (taxanes). The cream is applied directly to affected areas, and the research team will track whether it improves your symptoms and pain levels over time.
Boulogne-Billancourt, HAUTS DE SEINEAges 18 years+ - NCT07270549RecruitingPhase 1/Phase 2
Gene therapy trial for children with CTNNB1 syndrome
This trial tests a one-time gene replacement therapy given into the fluid around the brain to help children with CTNNB1 neurodevelopmental syndrome. The goal is to see if replacing the faulty gene can improve development and reduce symptoms.
LjubljanaAges 2–12 - NCT07503522Recruiting
Personalized music and exercise for stroke recovery
This study tests whether adding personalized music to gentle aerobic exercise helps people recovering from a recent stroke improve faster. It's for patients in the early weeks or months after stroke who can sit, understand instructions, and don't have major heart or thinking problems.
Ho Chi Minh City, Ho Chi MinhAges 18 years+ - NCT06776848RecruitingPhase 1/Phase 2
Lithium for TBR1-related neurodevelopmental disorder
This trial tests whether taking lithium for 2 years can improve symptoms in people with a TBR1 gene change that causes neurodevelopmental challenges. It aims to see if lithium is safe and helpful for this condition.
DijonAges 6 years+ - NCT07393620Recruiting
Predicting brain outcomes in newborns with mild oxygen loss
This study uses brain monitoring and oxygen measurements in newborns who had a mild lack of oxygen at birth to see if these tests can predict how the baby will develop. The goal is to find early signs that might help guide care.
BursaAges birth–6 hours - NCT07696936Recruiting
Robot vs manual arm artery brain scan trial
This trial tests if a robot can help perform a brain artery scan through the wrist as safely and effectively as the standard manual method. It might be an option if you need a detailed look at blood vessels in your brain.
Shijiazhuang, HebeiAges 18–80 - NCT07631182Recruiting
Action Observation Therapy for Stroke Recovery via Telehealth
This trial tests a therapy where you watch videos of hand and arm movements and then practice them yourself, delivered through video calls from home. It's designed to help people recover arm and hand function after a stroke.
Karabük, MerkezAges 18 years+ - NCT06662188RecruitingPhase 1/Phase 2
Gene therapy for children with SHANK3-related condition
This trial tests a gene therapy called JAG201 for children with a SHANK3 mutation or 22q13.3 deletion, which causes Phelan-McDermid syndrome. The goal is to see if it can help with development and daily function.
Chicago, IllinoisAges 2–9 - NCT06666829Recruiting
Personalized rehab with robotics for kids with developmental disabilities
This trial tests a personalized rehabilitation plan that uses new technology and robotic devices to help children and teens with developmental disabilities. The goal is to see if combining these tools can improve daily skills and quality of life.
Genova, GenovaAges 5–21 - NCT07257367Recruiting
Pressure sensing sheath vs. traditional blood pressure monitoring in wrist procedures
This trial compares a new pressure-sensing sheath that monitors blood pressure during wrist-artery procedures to the traditional method. It aims to see if the new device works just as well or better, and is for patients who are already scheduled for a planned (not emergency) procedure needing continuous blood pressure monitoring.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06945705RecruitingPhase 2
Targeted therapy for EGFR-mutant lung cancer with brain spread
This trial tests a combination of two targeted pills (furmonertinib and anlotinib) as a first treatment for people with advanced EGFR-mutant non-small cell lung cancer that has spread to the brain. It aims to see if this combination works better than the standard approach for controlling the cancer.
ZhengzhouAges 18 years+ - NCT07625007Recruiting
Shortwave Therapy for Diabetic Nerve Pain
This trial tests a shortwave treatment to relieve pain and other nerve symptoms in people with diabetic peripheral neuropathy (nerve damage from diabetes). It is for adults who have not found enough relief from standard nerve medications.
ChongqingAges 18–85 - NCT06771531Recruiting
Brain stimulation for foot sensation in older adults
This trial tests whether a gentle brain stimulation technique can improve feeling and steadiness in the feet of older adults who have numbness or reduced sensation. It aims to help with balance and walking.
Roslindale, MassachusettsAges 65 years+ - NCT07061769Enrolling by invitation
Using a gentle head device to help with nerve pain from chemo
This trial tests a low-intensity cranial PEMF device to see if it can reduce nerve pain caused by chemotherapy. Participants use the device at home and receive text messages to track their symptoms.
Newport Beach, CaliforniaAges 18–60 - NCT06863649Recruiting
Games for shoulder and arm pain after a stroke
This trial tests if doing fun, non-immersive video game–like exercises for a short time can help reduce chronic pain in the shoulder or arm after a stroke. It looks at whether these exercises can improve arm movement and make daily activities feel easier.
Exeter, DevonAges 18 years+ - NCT07249801Recruiting
Brain stimulation study for hand grip and vision coordination
This trial uses a technique called closed-loop rTMS-EEG, which combines brain stimulation with brain-wave monitoring, to study how the brain controls hand grip based on visual cues. It may help researchers understand movement and vision integration.
Charleston, South CarolinaAges 18 years+ - NCT06692686Recruiting
Testing ankle braces to improve walking after stroke
This trial is studying how different types of ankle braces (AFOs) affect walking ability in people who have had a stroke. It may help find the best brace to improve mobility.
Downey, CaliforniaAges 18 years+ - NCT06698705Recruiting
EEG study of remimazolam anesthesia in children
This trial studies brain activity (EEG) in children receiving remimazolam, a type of anesthesia. It aims to understand how the drug affects the brain during surgery.
Wenzhou, ZhejiangAges 1–12 - NCT07369999RecruitingPhase 3
Butylphthalide plus tenecteplase for mild disabling stroke
This trial tests whether adding butylphthalide (a drug that improves blood flow) to the standard clot-busting medicine tenecteplase can help people with mild but disabling strokes recover better. If you have had a mild stroke within the last 4.5 hours and are 18–80, this study might be an option for you.
Changsha, HunanAges 18–80 - NCT06706102RecruitingPhase 4
Study of Tiny Blood Particles During CAR-T Therapy
This study is for people getting CAR-T cell therapy, a type of cancer treatment that uses your own immune cells. Researchers want to understand a rare side effect called neurotoxicity by looking at tiny particles in your blood called extracellular vesicles.
Saint-EtienneAges 18 years+ - NCT06201026Recruiting
Reducing Fatigue in New MS With Individualized Training
This trial tests if a personalized home training program can help reduce severe fatigue in people with relapsing-remitting MS who were recently diagnosed. You'll use a phone app to do exercises designed for you, and researchers will check your energy levels over time.
Saint-EtienneAges 18–60
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.