Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07330063RecruitingPhase 2
Pain relief injection after laparoscopic stomach cancer surgery
This trial tests an injection called Anrikefon to see if it can safely and effectively reduce pain after surgery to remove part of the stomach for cancer. The surgery is done through small cuts (laparoscopic), and this treatment is given after surgery to help with pain while you recover.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07325565Recruiting
Emotional health and immunotherapy for liver cancer
This trial studies how emotional well-being affects how well immunotherapy works for liver cancer. It is for people newly diagnosed with liver cancer who have not yet been treated.
Wuhan, HubeiAges 18–75 - NCT07330284Recruiting
Cold water rinse to prevent pancreatitis after ERCP
This trial tests whether rinsing the pancreas with cold water during ERCP can reduce the risk of pancreatitis, a common complication. The treatment is added to the standard medicine (indomethacin) to see if it offers extra protection.
Kansas City, KansasAges 20 years+ - NCT07329296Enrolling by invitation
Liver regeneration after living donor transplant study
This study looks at how the donor's liver grows back after donating a part of it for a living donor liver transplant. If you have donated a part of your liver between 2004 and 2026, joining could help doctors learn more about liver healing.
Rotterdam, South HollandAges 18–60 - NCT07333144Recruiting
Bleeding from the gut while on blood thinners
This study collects information from patients who come to the emergency room with gastrointestinal bleeding while taking certain newer blood thinners. It aims to better understand and manage this type of bleeding.
StrasbourgAges 18 years+ - NCT07333053Recruiting
Chemotherapy through a catheter for advanced colorectal cancer
This trial tests giving chemotherapy directly into the artery that feeds the tumor, which may help control advanced colorectal cancer that cannot be removed with surgery. It is for people who have not yet had other treatments and whose main tumor is in the colon or rectum.
Xicheng, Beijing MunicipalityAges 18 years+ - NCT07333716RecruitingPhase 2
Desloratadine for mild to moderate UC
This trial tests whether desloratadine, an allergy medicine (antihistamine), can help reduce inflammation in people with mild to moderate ulcerative colitis. All participants must already be taking mesalamine and cannot be on other stronger UC treatments.
Shibīn al Kawm, MenofiaAges 18–65 - NCT07325630RecruitingPhase 2
Perioperative study of IBI363 for MHC-II-negative advanced stomach cancer
This trial tests a new treatment called IBI363 given before and after surgery for people with a certain type of advanced stomach cancer that lacks the MHC-II marker. The goal is to see if it helps shrink the tumor and improve outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT07327905Recruiting
Lidocaine or dexmedetomidine for pain during weight-loss surgery
This trial compares two medicines given through an IV during sleeve gastrectomy (weight-loss surgery) to see which provides better pain control. It may help patients have a smoother recovery with less discomfort.
AlexandriaAges 20–50 - NCT07329933Recruiting
Steroids and sedatives for faster recovery after gallbladder surgery
This trial tests if adding two medicines, dexamethasone and dexmedetomidine, helps the stomach and intestines work better after keyhole gallbladder removal. The goal is to see if the combination can get your digestion back to normal faster.
BanhāAges 18–65 - NCT07329894RecruitingPhase 1
XH001 and vaccine-activated T cells for advanced GI cancer
This trial tests a two-part treatment: an injection called XH001 plus a custom vaccine that trains your immune cells to attack tumors. It's for people with advanced stomach or bowel cancer that hasn't responded to at least two prior treatments.
BeijingAges 18–70 - NCT07331883RecruitingPhase 2
Sintilimab and bevacizumab after surgery for ruptured liver cancer
This trial tests whether combining two immune-based drugs (sintilimab and a bevacizumab biosimilar) after surgery can prevent liver cancer from returning in people whose tumor had ruptured. It’s for patients who have had a complete surgical removal of a ruptured hepatocellular carcinoma and are now cancer-free on imaging.
Sanming, FujianAges 18–75 - NCT07328880Recruiting
Two bowel prep methods before colonoscopy study
This trial compares two ways to clean the bowel before a colonoscopy: a 4-liter split-dose of a laxative plus two other medications versus a 2-liter split-dose with a gas-relief medication. The goal is to see which works better and is easier to tolerate.
Tanta, GharbyeaAges 18–70 - NCT07330830Recruiting
Genetics and fatty liver disease in Caribbean and Indian Ocean populations
This study looks at how a specific gene (PNPLA3) might affect non-alcoholic fatty liver disease (MASLD) in people from Guadeloupe, French Guiana, and Réunion Island. It aims to understand genetic differences that could explain why some people get the disease.
CayenneAges 18 years+ - NCT07325344Recruiting
Magnetically guided camera pill for small bowel exam
This trial tests a new way to move a camera pill through your small intestine using magnets. It is designed for people who already need a small bowel exam, and looks at how well the magnetic control works.
Jinan, ShandongAges Any age - NCT07328607Recruiting
Comparing Keyhole vs Open Pancreas Surgery
This trial compares two surgical approaches for removing tumors in the head of the pancreas or nearby areas: 'keyhole' (laparoscopic) surgery versus traditional open surgery. The goal is to see if the keyhole method offers similar results with a faster recovery.
Minya, Minya GovernorateAges 18–75 - NCT07328698Recruiting
Ozonated oil dressing after hernia surgery pilot
This study tests whether a special oil dressing (ozonated oil) can help heal the surgical wound better after open inguinal hernia repair. It compares the oil dressing to a standard dressing to see if it reduces pain, infection, or other complications.
Niğde, Niğde ProvinceAges 18–75 - NCT03579836RecruitingPhase 1/Phase 2
Test BEY1107 plus gemcitabine for pancreatic cancer
This early study tests whether BEY1107 given alone or with gemcitabine can be used safely and may help shrink pancreatic cancer tumors. It mainly looks at safety, side effects, and signs of effectiveness in people with pancreatic ductal cancer.
SeoulAges 20–80 - NCT05093907RecruitingPhase 1/Phase 2
Testing a new cancer drug plus capecitabine for metastatic colon cancer
This trial studies whether BEY1107, a new treatment, is safe and works better when combined with capecitabine in people with metastatic colorectal (colon/rectum) cancer. It is aimed at cancers that have already progressed after standard chemotherapy.
Seoul, Jongro-goAges 19 years+ - NCT06776029RecruitingPhase 2
Fecal transplant for radiation-induced rectal bleeding
This study tests whether a fecal (stool) transplant can help heal rectal damage caused by pelvic radiation. The treatment may decrease bleeding and improve symptoms for people whose supportive care hasn't worked well.
Guangzhou, GuangdongAges 18–75 - NCT06742892RecruitingPhase 2
Study of HLX43 for advanced liver cancer after standard treatment fails
This trial tests a new drug, HLX43, for people with advanced liver cancer (HCC) that has worsened or caused intolerable side effects after standard treatments like immunotherapy or targeted therapy. The goal is to see if HLX43 can help when other options have stopped working.
Hunan, HunanAges 18–75 - NCT06736314Recruiting
Removable clip treatment for stomach varices bleeding
This trial tests a removable titanium clip to stop bleeding from enlarged veins in the stomach caused by cirrhosis. It may be an option for patients who are stable enough for this procedure.
Nanjing, JiangsuAges 18–75 - NCT06736301Recruiting
Stent fixation for benign duodenal strictures
This trial tests a method to keep a metal stent in place using a plastic stent for people with non-cancerous narrowing in the first part of the small intestine. It may help if you have symptoms like nausea or vomiting and other treatments have not worked.
Nanjing, JiangsuAges Up to 75 years - NCT06773312RecruitingPhase 1
Study of BC001 plus Sintilimab and XELOX for advanced stomach cancer
This trial tests a combination of three drugs (BC001, Sintilimab, and XELOX chemotherapy) for people with advanced or metastatic HER-2 negative stomach cancer or cancer where the stomach meets the esophagus. The goal is to see if this combination works better than standard treatments.
Beijing, Beijing MunicipalityAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.