Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT06866496Recruiting
Better remission in alcohol-related liver cirrhosis
This trial tests if an optimized treatment plan can improve remission in people with liver cirrhosis caused by alcohol. It aims to help patients achieve better health outcomes.
Hvidovre, Capital RegionAges 18 years+ - NCT06867172Recruiting
Fat in the pancreas in people with cysts or cancer
This study looks at whether fat buildup in the pancreas (called pancreatic steatosis) is common in people who have pancreatic cysts or pancreatic cancer. It may help doctors better understand these conditions.
Bucharest, Sector 1Ages 18 years+ - NCT06867419Recruiting
Metabolic effects on fatty liver disease score
This study looks at how certain features of your metabolism affect a simple score (called the FAST score) in people with fatty liver disease (MASLD). It aims to help doctors better understand and manage the condition.
Tanta, GharbyeaAges 18 years+ - NCT05246657Recruiting
EUS procedure to bypass blocked bile ducts when ERCP fails
This trial studies a new way to access the bile ducts using a scope guided by ultrasound when standard ERCP can’t be done or doesn’t work. It may help people with non-cancer (benign) bile duct blockages get the bile flowing again.
ValladolidAges 18 years+ - NCT03895359RecruitingPhase 3
Chemo plus targeted radiation versus chemo alone for liver cancer
This trial compares two treatments for liver cancer that can’t be removed with surgery: chemo through the liver (TACE) alone versus TACE plus a precise radiation treatment (SBRT). It may help people whose cancer stays in the liver but can’t be operated on, by testing whether adding focused radiation improves outcomes.
London, OntarioAges 18 years+ - NCT03921502Recruiting
ERCP vs ERCP with a stomach drainage procedure comparison
This trial compares two endoscopy approaches to drain a blocked bile duct caused by gallstones. It may help people who can’t safely have standard surgery decide which drainage method works best after an initial ERCP plan fails or is limited.
ValladolidAges 75 years+ - NCT04745390Recruiting
Testing a tailored radiation dose plan for liver tumors
This study compares a standard radiation dose plan versus a plan that adjusts the dose based on how the tumor responds to radiation-related measurements. It aims to improve how well stereotactic body radiation therapy (SBRT) treats liver cancer while keeping side effects manageable.
London, OntarioAges 18 years+ - NCT05803993Recruiting
Fecal transplant to ease constipation in irritable bowel syndrome
This trial tests whether transferring stool bacteria to the gut (fecal microbiota transplantation) can reduce symptoms of irritable bowel syndrome with constipation. It may help by changing the gut microbiome, but you must meet safety and health requirements.
RomaAges 18 years+ - NCT05803980Recruiting
Fecal transplant to ease IBS diarrhea symptoms
This study tests whether fecal microbiota transplantation (a stool-based treatment to change gut bacteria) can reduce symptoms of irritable bowel syndrome (IBS) that comes with diarrhea. You may be eligible if you’re an adult with diarrhea-predominant IBS and recent colonoscopy results that rule out other intestinal diseases.
RomaAges 18 years+ - NCT06031025Recruiting
Study of tummy problems in at-risk infants
This study looks at how common stomach and gut issues are in babies who were born early or had problems at birth, and how these issues change over time.
RomaAges 3 months–2 years - NCT06812390RecruitingPhase 2
Albumin plus diuretics for cirrhosis-related leg swelling
This study tests whether giving albumin (a protein) along with water pills helps reduce leg swelling in people with cirrhosis and ascites. It may be an option if your leg swelling hasn't improved with standard diuretics alone.
West Haven, ConnecticutAges 18 years+ - NCT06865807Recruiting
Comparing stitches for emergency belly closure
This trial compares two different types of stitches used to close the belly after emergency abdominal surgery. The goal is to find out which stitch leads to better healing and fewer complications.
Santa Cruz de TenerifeAges 18 years+ - NCT07317076Recruiting
Magnetic device study for stomach and bowel blockages
This trial tests a new magnetic device that creates a connection between parts of your stomach or small intestine without needing stitches, for people with certain blockages or digestive issues.
Westmount, QuebecAges 18 years+ - NCT07318051Recruiting
Sample collection for cancer research study
This study collects blood and tumor tissue samples from patients with certain untreated cancers to help researchers develop and improve tests. You may be eligible if you have one of the listed cancer types and have not yet started treatment.
Austin, TexasAges 18 years+ - NCT07321106RecruitingPhase 1
CBI-1214 for advanced colorectal cancer
This trial tests a new drug called CBI-1214, which is designed to help your immune system attack cancer cells. It is for people with advanced colorectal cancer that has not responded to other treatments.
Phoenix, ArizonaAges 18 years+ - NCT07319832Recruiting
Teduglutide study for children with short bowel syndrome
This trial tests the medicine teduglutide in children (ages 1–17) with Short Bowel Syndrome who need IV nutrition. The goal is to see if teduglutide can help them reduce or stop IV nutrition.
Guangzhou, GuangdongAges 1–17 - NCT07324304RecruitingPhase 2
DNA vaccine for liver cancer after curative surgery
This trial tests a DNA-based vaccine called NWRD06 to lower the risk of liver cancer returning after a curative surgery or ablation. It is for people with a specific protein on their cancer cells and good liver function.
Beijing, Beijing MunicipalityAges 18–65 - NCT07315750RecruitingPhase 3
Study of three drugs vs standard care for HER2-high stomach cancer
This trial tests a new combination of drugs (Disitamab Vedotin, Trastuzumab, and Tislelizumab) against standard chemotherapy plus Trastuzumab (with or without Pembrolizumab) for people with advanced or metastatic stomach or gastroesophageal junction cancer that has high levels of HER2. The goal is to see if the new combination works better.
Beijing, BJ-BeijingAges 18–75 - NCT07318805RecruitingPhase 1
A study of PF-08032562 for advanced solid tumors
This study tests a new medicine, PF-08032562, for people with advanced breast or colorectal cancer that has not responded to prior treatments. It aims to see if the drug is safe and can help shrink or slow the cancer.
Duarte, CaliforniaAges 18 years+ - NCT07317505RecruitingPhase 1
Study of JMT108 for Advanced Solid Tumors
This trial tests a new drug called JMT108 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The study aims to see if the drug is safe and how it affects the body.
Huntersville, North CarolinaAges 18 years+ - NCT07320287Recruiting
Probiotics for babies born by C-section
This trial tests whether a multi-strain probiotic supplement can help with growth, digestion, and gut health in healthy full-term babies who were born by C-section.
HanoiAges birth–1 day - NCT07316517Recruiting
Robot-assisted hernia repair with Versius system
This study tests whether a robot-assisted device called Versius can be used safely and effectively for inguinal hernia repair surgery. If you are already scheduled for minimally invasive hernia repair, you may be able to join.
MilanAges 22 years+ - NCT07321925Recruiting
Using sound waves to measure liver fat
This study tests a new method that uses sound waves to measure fat in your liver. It could help doctors check liver health without a biopsy.
Ann Arbor, MichiganAges 18 years+ - NCT06870942RecruitingPhase 2
Radiation therapy for liver cancer that progresses after first immunotherapy
This trial tests whether adding targeted radiation to liver cancer patients who have limited progression after initial immunotherapy can help control the disease. It is for people with hepatocellular carcinoma (HCC) whose cancer has started to grow in just a few spots after their first PD-1 treatment.
Shanghai, Shanghai MunicipalityAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.