Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07268261Recruiting
New surgery for chronic anal fissure
This trial tests a new combined surgical method for people with a chronic anal fissure (a small tear in the skin around the anus) that has not healed and is causing muscle spasms. The goal is to see if this surgery can help the fissure heal and relieve pain and spasm.
MoscowAges 18–70 - NCT06896409Recruiting
PuraStat and adrenaline vs standard care for upper GI bleeding
This trial tests whether a gel called PuraStat, used together with adrenaline, works better than standard care to stop bleeding in the upper digestive system. It may help people who need an endoscopic procedure to treat non-variceal bleeding.
LleidaAges 18 years+ - NCT07263919RecruitingPhase 2
Chemo plus cadonilimab before surgery for esophageal cancer
This trial tests adding cadonilimab to standard chemotherapy before surgery for esophageal cancer that can be removed. It aims to see if this combination helps shrink the tumor and improve outcomes.
Xi'anAges 18–75 - NCT07262567RecruitingPhase 3
New drug vs chemo for KRAS G12D pancreatic cancer
This study tests a new targeted drug, GFH375, against standard chemotherapy for people with advanced pancreatic cancer that has a specific genetic change called KRAS G12D. The goal is to see if the new drug works better and has fewer side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT07261631RecruitingPhase 1
A study of a new radioactive drug for advanced solid tumors
This trial tests a new radioactive drug called [177Lu]Lu-DFC413 for people with certain advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target cancer cells with a specific marker seen on a special scan.
Princeton, New JerseyAges 18 years+ - NCT07263594RecruitingPhase 1/Phase 2
Study of DB-1324 for advanced stomach or bowel cancers
This trial tests a new drug called DB-1324 for people with advanced gastrointestinal cancers that have stopped responding to standard treatments. It targets a protein called CDH17 on cancer cells to slow or shrink the tumor.
Port Saint Lucie, FloridaAges 18 years+ - NCT07267169Recruiting
Blood filtering for acute pancreatitis
This trial tests whether a special blood filter (Efferon LPS) can help people with moderate to severe acute pancreatitis by removing harmful substances. It is for those who have been sick for 5 days or less and have certain signs of inflammation or organ stress.
Kazan'Ages 18–75 - NCT07265674RecruitingPhase 3
Study of nanvuranlat for advanced bile duct cancer
This study tests a new drug called nanvuranlat for people with advanced bile duct cancer that has gotten worse after platinum-based chemotherapy. It compares nanvuranlat with the doctor's choice of standard treatments to see which works better.
Duarte, CaliforniaAges 18 years+ - NCT07265570RecruitingPhase 2
ISM5411 for active ulcerative colitis
This trial tests an experimental drug (ISM5411) for people with active ulcerative colitis. The goal is to see if the drug can reduce inflammation and improve symptoms.
Beijing, Beijing MunicipalityAges 18–75 - NCT07259590RecruitingPhase 1/Phase 2
GFH375 with cetuximab or chemo for KRAS G12D cancers
This trial tests a new drug called GFH375 combined with either cetuximab or chemotherapy for people with advanced solid tumors that have a specific genetic change called KRAS G12D. It's for those whose cancer has worsened after other treatments or who can't have standard therapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07263178Recruiting
Second-line chemo for advanced colorectal cancer
This study looks at different chemotherapy options for people with metastatic colorectal cancer that has stopped responding to first treatment. It aims to find which second-line approach works best.
SeoulAges 19 years+ - NCT06895785Recruiting
Single-use vs reusable scope for bile/pancreatic duct issues
This trial compares a single-use scope to a reusable one for people with bile duct or pancreatic duct problems. It aims to see if the single-use scope works as well and may reduce infection risk.
Chicago, IllinoisAges 19 years+ - NCT03471793Recruiting
Test for removing large, flat colon growths by endoscopy
This study looks at patients who have a large, flat (sessile) or spreading growth in the colon that doctors plan to remove using an endoscopy. It aims to study the endoscopic removal process and outcomes for these bigger lesions.
Westmead, New South WalesAges 18–99 - NCT02198976Recruiting
Study for adults with Barrett’s esophagus
This study looks at people age 18+ who have Barrett’s esophagus and checks for early changes that may lead to cancer. You might qualify if you can consent and are not pregnant.
Westmead, New South WalesAges 18–99 - NCT03471403Recruiting
Cold snare removal for duodenal growths in FAP
This trial studies removing small growths in the duodenum (a part of the small intestine) in people with familial adenomatous polyposis (FAP) using a “cold snare” technique. It may help reduce the need for more intensive treatment and make follow-up care safer, but you must meet specific safety and readiness requirements.
Westmead, New South WalesAges 18–99 - NCT04008407Recruiting
Monitoring outcomes after removing certain colon growths
This study follows patients who are having surgery to remove a specific type of flat colon growth. It aims to see how safe and effective a “selective” approach is, based on what the growth looks like and your situation.
Westmead, New South WalesAges 18 years+ - NCT05041478Recruiting
Cold removal method for large colon polyps
This trial compares two cold endoscopic techniques to remove certain large, non-cancerous colon polyps with better control of bleeding and leftover tissue. You may be offered one of the two removal methods during your scheduled colonoscopy.
Westmead, New South WalesAges 18 years+ - NCT05299840Recruiting
Test a device to choose the first chemo for metastatic colon cancer
This study tests whether using the Oncogramme® device to guide the first-line treatment improves care for people with metastatic colorectal (colon/rectum) cancer. If the device helps pick the most suitable standard chemotherapy plan, it could lead to better outcomes than choosing without it.
MarseilleAges 18 years+ - NCT07267468Recruiting
App and nutrition plan for swallowing recovery after stroke
This study tests a mobile health program combining rehabilitation exercises and a personal nutrition plan to help people recover from swallowing problems (dysphagia) after a stroke. The goal is to see if using the app improves swallowing and quality of life.
Algeciras, CadizAges 18 years+ - NCT07268820RecruitingPhase 4
Nighttime heartburn treatment for erosive GERD
This trial tests a treatment for nighttime heartburn caused by GERD, a condition where stomach acid damages the esophagus. It is for adults who have had nighttime heartburn for more than 3 months and have been diagnosed with erosive GERD.
AnsanAges 19 years+ - NCT07259395Recruiting
Predicting ERCP procedure time with a new tool
This trial is testing a tool to predict how long an ERCP procedure will take. It involves ERCPs done by trainees under supervision and uses a tiny camera inside the bile duct.
BrusselsAges 18 years+ - NCT07262957RecruitingPhase 4
Preventing complications after pancreatic surgery with a drug bundle
This trial tests whether giving a combination of three treatments—hydrocortisone (a steroid), octreotide (a drug that reduces digestive fluids), and a tissue patch—before and during pancreatic surgery can help prevent complications. It is for people with a very small pancreatic duct (3 mm or less) who are scheduled for pancreatic surgery.
AmsterdamAges 18 years+ - NCT07264036Recruiting
Nasal Speech After Head and Neck Cancer Treatment Study
This study is for people who have had treatment for head or neck cancer and now have a nasal-sounding voice. It tests a procedure to help improve speech by adding a small amount of filler material to the back of the throat.
Charlottesville, VirginiaAges 18 years+ - NCT07268131Recruiting
TITAN-HCC: Testing immunotherapy plus TACE for liver cancer beyond standard criteria
This trial tests a combination of an immunotherapy drug (QL1706) and a liver-directed procedure (TACE) before and after surgery for people with liver cancer that is larger or more advanced than the usual transplant criteria. The goal is to see if this approach can help shrink the tumor and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.